Báo cáo y học: "Direct interaction of immunoglobulins with synovial fibroblasts: a missing link in the pathogenesis of rheumatoid arthritis" potx

... may interact directly with fibroblast-like cells and through this interaction form part of a signalling loop that ultimately results in the maintenance of local inflammation. Consequently, the ... directly to the pathogenesis of synovial inflammation and joint destruction has seen a ‘revival’ over the last couple of years [6,7]. This is mainly due to the observ...

Ngày tải lên: 09/08/2014, 06:22

... Eva Balaziova 1 and Liliana R Sedova 3 1 Laboratory of Cancer Cell Biology of the 1 st Faculty of Medicine, Charles University, Prague and the Institute of Physiology, Academy of Sciences, Prague, ... Koshiba M, Nakazawa T, Hatachi S, Saura R, Kurosaka M, Kusaka H, Kumagai S: Specific increase in enzy- matic activity of adenosine deaminase 1 in rheumatoid syn- ovial fibr...

Ngày tải lên: 09/08/2014, 07:20

... OA-damaged cartilage. TGFβ- induced synovial fibrosis was blocked by locally inhibiting TGFβ signaling in the synovial lining by simultaneously transfecting it with an adenovirus overexpressing ... favoring the catabolic side is very likely involved in the pathological fea- tures of OA. Currently, many attempts are being made to repair the carti- lage that has been damaged...

Ngày tải lên: 09/08/2014, 07:20

... 7:33 http://www.journal-inflammation.com/content/7/1/33 Page 2 of 7 [2,7]. These are used to manipulate the basal transcrip- tional machinery and the chromatin structure through altering their acetylation and methylation status and thereby regulating ... HDAC-2 antibody (Santa Cruz Biotechnology, CA, USA); mSin 3a antibody (Abcam, Cambridge, UK); Mi2α/ β antibody (Austral Biotechnology...

Ngày tải lên: 11/08/2014, 03:20

... collection and thematic content analysis occurring simultaneously; detailed analysis of the thematic codes; a nd matrix ana- lysis of codes. The first stage was an iterative process with coding analysis ... asked you to do?’‘What made you decide to take the letter with you to your appointment rather thanjustleavingitathome?’‘What would you say was the main reason that you we...

Ngày tải lên: 11/08/2014, 05:21

... 7:33 http://www.journal-inflammation.com/content/7/1/33 Page 2 of 7 [2,7]. These are used to manipulate the basal transcrip- tional machinery and the chromatin structure through altering their acetylation and methylation status and thereby regulating ... HDAC-2 antibody (Santa Cruz Biotechnology, CA, USA); mSin 3a antibody (Abcam, Cambridge, UK); Mi2α/ β antibody (Austral Biotechnology...

Ngày tải lên: 11/08/2014, 06:22

... interface and the linea alba, and the VAT was defined as the distance between the anterior wall of the aorta and the internal face of the recto-abdominal muscle perpendicular to the aorta. When the aortic ... dottpatty@libero.it; Paolo Conca - paoloconca@unina.it; Carmine Finelli - pasanisi@unina.it; Matteo Nicola Dario Di Minno - diminno@unina.it; Marianna Tarantino -...

Ngày tải lên: 11/08/2014, 08:22

... in the synovial- infiltrated lymphocytes of RA patients rather than in the synovial lining cells. We could not detect the IL-32 expression in the synovial lining layers, where monocytes and synovial ... 5'-TGGGAGTAGACAAGGTACAACCC-3' Mouse IL-1β Sense 5'-CAACCAACAAGTGATATTCTCCATG-3' Antisense 5'-GATCCACACTCTCCAGCTGCA-3' Mouse IL-6 Sense 5&ap...

Ngày tải lên: 09/08/2014, 08:23

... Analyses of BALF chemokine and cytokine levels can probably provide therapeutic targets in SSc-associated ILD. Competing interests The authors declare that they have no competing interests. Authors' ... these experiments. The assay was performed according to the man- ufacturer's instructions. Cytokine concentrations were auto- matically calculated with Bio-Plex Manager s...

Ngày tải lên: 09/08/2014, 14:22

... of packets in the buffers can vary significantly, and there is a relatively high probability that the buffers are empty. For example, in time-slotted networks, the packets in the queues are aggregated into ... associated decision metrics in these schemes are based on the com- bination of the delay and instantaneous channel rates. Finding an optimal metric based on these...

Ngày tải lên: 21/06/2014, 23:20