Báo cáo y học: "CXCR3/CXCL10 expression in the synovium of children with juvenile idiopathic arthritis" pot

... of definite TCR gene regions, indicatingFigure 5CXCR3 expression in the synovium of a patient with juvenile idiopathic arthritisCXCR3 expression in the synovium of a patient with juvenile idiopathic ... into the inflamed synovium. The high expression of CXCR3 by T cells retrieved from the synovia of patients with JIA might be considered a by-prod-uct of the in vivo cell hyperactivity of the ... regulating overexpression of CXCR3/CXCL10 might help in defining the role of thesemolecules in synovial inflammatory responses, offering newinsights into elements controlling the immune responsewithin...

Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"

... including carbamazepine, phenytoin,phenobarbital, and lamotrigine. The triad of hypersensi-tivity includes fever, rash and internal organ involvement with onset of symptoms within 1 to 8 weeks of ... purposes) of portacaval shunting, thereby decreasing first passmetabolism; decrease in quantities and affinity of plasmaproteins, thereby increasing free-drug levels; increase in volume of distribution ... [57].Recognizing early symptoms of hepatic toxicity and dis-continuing treatment are important in optimizing recov-ery. Early symptoms of hepatic toxicity include apathy,malaise, fever, diminished...

Báo cáo y học: "Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes" ppt

... fibroblast lines. YM participated in the molecular genetic studies and analysis. EK procured the sam-ples and helped in the analysis of data. GW participated in the design of the study, analysis of data, ... derived from the amino terminus of mtND1 [14]. These findings provide evi-dence that antigenic peptides of human mtND1 may be dis-played and recognized by the immune system.To test the hypothesis ... earlybacterial infection in the joint. Somatic mutations in mitochondrial peptides displayed by MHCs may be recognizedas non-self, furthering the destructive immune infiltration of the RA joint....

Báo cáo y học: "Psychosocial aspects in the management of arthritis pain" pot

... [16]compared the psychosocial functioning and coping of mothers with chronic pain (including mothers with arthritis) tomothers without pain, with regard to their ratings of parentingefficacy. There ... of leisure in maintaining or restoring psychological well-being in the presence of arthritis pain warrants furtherstudy.Psychosocial approaches to managingarthritis painSearch strategy The ... Acomparison of conventional pain coping skills training andpain coping skills training with a maintenance training com-ponent: A daily diary analysis of short- and long-term treat-ment effects. J Pain...

Báo cáo y học: " Immune mechanisms in the pathogenesis of idiopathic inflammatory myopathies" doc

... understanding of the role of these inflammatory cells in disease mechanisms in IIMs. In this review we summarize the latest findings concerning the role of T lymphocytes, B lymphocytes, dendritic ... demonstrated the presence of differentiated B lymphocytes in the form of CD138+plasmacells predominantly in the endomysium of muscle tissue of patients with polymyositis and inclusion-body myositis ... findings concerning the role of T lymphocytes, B lymphocytes, dendritic cells, and other antigen-presenting cells in the pathophysiology of IIMs.Introduction Idiopathic inflammatory myopathies (IIMs)...

Báo cáo y học: "Current approaches in the treatment of arthritic pain" pps

... beconfined to the periphery. The finding of increased areas of punctate hyperalgesia in patients with RA after topicalapplication of capsaicin is in accord with increasedexcitability of spinal ... also likely to influence activity. The multiplicity of mediators involved provides an opportunity for therapeuticintervention, and many of the commonly used therapeuticstrategies including acupuncture, ... concept of a fixed immutable pain system thatfaithfully transmits information from a site of injury to paincentres within the brain. Although this is largely true afteracute injury, it is...

Báo cáo y học: "Recent developments in the immunobiology of rheumatoid arthritis" potx

... past couple of years advances have been made in the understanding of the involvement of T cells in the immunopathology of autoimmune diseases, with a focus onproinflammatory cytokine production, ... cells, the products they produce, including cytokines andautoantibodies, and the genetic factors potentially involved in their regulation and function.T cells In contrast to the clearly defined ... with anti-IL-15 therapy in RA patients [29].T helper 17 cellsThere is increasing evidence that IL-17 plays a role in the immunopathology of RA. This proinflammatory cytokine isproduced by...

Báo cáo y học: "Computational challenges in the analysis of ancient DNA" ppsx

... explained in the following way. The chance of finding a seed-match and of producing a local alignment of significant similarity rises with the length of the frag-ment. Longer fragments, then, ... shown). Thisindicates that reads of this size are too short to identify the originating species reliably. For this study, we evaluate the influence of a size cutoff of 35 bp.Since the simulated ... sequencesinclude only a small proportion of microbes found in nature [14]. Finally, the target genome used for detection of fragments of interest may not be sufficiently similar tothat of the extinct organism...

Báo cáo y học: "Clinical significance in the number of involved lymph nodes in patients that underwent surgery for pathological stage III-N2 non-small cell lung cancer" pot

... Surgery appears to be preferable as a one arm of multimodality therapy in p-stage III/N2 patients with single or 2 involved lymp h nodes. The optimal incorporation of surgery into the multimodality ... patient s h ave been observed in a wide variety of clinical trials incorporating various com-binations of chemotherapy, radiotherapy, and surgery. The evidence of whether surgical treatment for ... computed tomography (CT) of the chest, and upper abdomen. The clinica l N2 status wasdefined by the presence of a lymph node more than 1 cm in the sho rt axis diameter . Bone sc intigraphy was per-formed...

Báo cáo y học: "Dendritic cells: In the forefront of immunopathogenesis and vaccine development – A review." doc

... thymus reactive T lymphocytes, they will be deletedindicating that DCs play a critical role in this process.Moreover, in the cortical area of the thymus, althoughmacrophages phagocytize dying ... delivery system also offers an interestingroute to approach DC subsets in order to enhance immu-nity against cancer or pathogens. Accordingly, the immune system of the skin harbors two very potent ... capability, they couldacquire tumor antigen. In the past few years the role of DCs in cancer has beensuggested. There is evidence that DCs can induce immu-nity to tumors if they are administrated...

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