Báo cáo y học: "Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case–control study" pot
Báo cáo y học: "Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case–control study" pot
... HLA -A1 , HLA-B8, HLA-DR3 haplotype, in atleast one healthy Caucasian population [11]. Furthermore,using a large UK Caucasian sample, Ahmad and coworkers[12] recently reported that TPSN polymorphisms ... in systemic onset juvenile rheumatoid arthritis: a family-based case–control studyHulya Bukulmez1,2,3,4, Mark Fife5, Monica Tsoras1, Susan D Thompson1, Natalie A Twine5, Patricia ... evidence of linkage of TPSN to JRA byapplying the family-based TDT only to the cohorts ofaffected individuals for whom parental and sibling informa-tion was available. These families included...
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Báo cáo y học: "Serum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus nonresponse to therapy" ppt
... serumamyloid A (SAA) [16]. Since SAA is a known biomarker ofactive SJIA [17], we compared the intensity of the 11.6-kDapeak with SAA levels in the sera, as determined by latex agglu-tination. As ... Medicine, Yokohama, Japan. All the patients wereAsian and their mean age at the start of the study was 7.25 ±0.92 years. Eight of them had obtained a clinical response toconventional therapy. ... proteins in a man-ner that compares favorably to quantitative methods such aslatex agglutination or enzyme-linked immunosorbent assay.Identification of SAA by SELDI-TOF MS helps validate ourexperimental...
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Báo cáo y học: "Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus" pptx
... psoriasis study analyzed a region previouslyidentified by linkage in sibling pairs, and by thoroughhaplotype analysis narrowed it down to a single polymorphism (having excluded the remaining nine ... so far in humans include the RUNX1 proteinpreviously known as AML 1a. AML 1a was originallyidentified because it is frequently involved in mutationsand translocations associated with acute myeloid ... of theirhematopoietic system in a dominant fashion [22]. In humans, haploinsufficiency due to structural mutations in RUNX1 leads to familial thrombocytopenia and a greatlyincreased risk for...
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Báo cáo y học: " Reduced antioxidant defense in early onset first-episode psychosis: a case-control study" pps
... Medical Psychology,University of Navarra, Pamplona, Spain.8Child And Adolescent PsychiatryUnit, Department of Psychiatry, Valdecilla Universiy Hospital, Santander,Cantabria, Spain.9Department ... Yao JK, Reddy R, van Kammen DP: Abnormal age-related changes ofplasma antioxidant proteins in schizophrenia. Psychiatry Res 2000,97:137-151.40. Machado-Vieira R, Andreazza AC, Viale CI, Zanatto ... were analyzed in a single batch. Oxida-tive stress was evaluated by measuring primaryenzymatic antioxidant defense (cellular glutathione per-oxidase, catalase and superoxide dismutase activities)and...
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Báo cáo y học: "Differential gene expression in HIV/SIV-associated and spontaneous lymphomas"
... 5’-GGAAGTGTTAGGGTTTGGTTTCT-3’ 60 capn4 5’-CCACAAGCTTTTGTTCTCTCAGTA-3’ 5’-CACAGGTACAGGGGAGAGGTTAC-3’ 60 pub 5’-TACTGACCGAGTGCTGAGACTACT-3’ 5’-GCAATTTGCCATATCAATAAAGAA-3’60 Northern blot analysis ... named 16S RNA most probably relates to the humanin gene [17], since its transcript contains poly (A) . According to our data (Tab. 5) a- myb was overexpressed in all AIDS-related lymphomas. At ... 5’-AGAAGTGGGGTGGCTTTTAGG-3’ 64 set 5’-ACCTGGTTTACTGACCATTCTGA-3’ 5’-TCTTCTTCACCTTCATCCTCATC-3’ 59 ND4 5’-TCCCCACCTTGGCTATCATC-3’ 5’-TTGTTGGCTCAGGAGTTTGA-3’ 60 a- myb 5’-AAGAAGAATCAGGCACTCAACTG-3’...
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Báo cáo y học: "Differential gene expression in pristane-induced arthritis susceptible DA versus resistant E3 rats" potx
... (Qiagen,Valencia, CA, USA). The purity and concentration of RNAwas determined by A 260/280analysis and the RNA qualitywas analyzed by agarose gel electrophoresis.Affymetrix analysisTotal ... microarray analysis may be a valuable toolfor cloning arthritis controlling genes and improving ourunderstanding of their biological pathways. Therefore,microarray analysis of animal models has ... Corporation, Sunnyvale, CA,USA) at 405 nm. Four rats per group were analyzed andall ELISA samples were run in duplicate.Statistical analysisThe Affymetrix data were analyzed by the Microarray...
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Báo cáo y học: " Angiogenesis gene expression in murine endothelial cells during post-pneumonectomy lung growth" pptx
... events.RNA and quantitative PCR In al l RNA isolatio ns, the total RN A quality w asassessed by using an Agilent 2100 Bioanalyzer (AgilentTechnologies, Palo Alto, CA). RNA integrity numbers(RIN) ... types–makesthisapproachparticularly appealing in the study of compensatorygrowth. In tissue-scale networks, any measura ble orquantifiable property can be considered a variable ofinterest to be associated with a ... lung was har-vested at the airway to minimize extra pulmonaryairway. The lung parenchyma was minced into 1 mm3pieces and processed by enzymatic digestion: 1 mg/mlcollagenase (Sigma, St....
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Báo cáo y học: "Smad gene expression in pulmonary fibroblasts: indications for defective ECM repair in COPD" ppsx
... repairing ciga-rette smoke induced lung damage. This repair processappears inadequate in a subset of smokers, leading togradually increasing parenchymal ECM destruction andemphysematous changes ... hand can affectthis pathway by inhibiting phosphorylation of Smad2and Smad3 and inducing ubiquination of their receptors.Additionally, Smad7 can induce TGFβ-production byfibroblasts upon activation ... gene expression. TGFβ, TNF, andCSE cause differential downregulation of decorin gene expression in COPD patients, at least partially via theSmad pathway. Our findings may explain why only a...
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Báo cáo y học: " WT1 PEPTIDE VACCINATION IN COMBINATION WITH IMATINIB THERAPY FOR A PATIENT WITH CML IN THE CHRONIC PHASE"
... Hirai M, Tominaga N, Nakajima H, Elisseeva OA, Masuda T, Nakano A, Kawakami M, Oji Y, Ikegame K, Hosen N, Udaka K, Yasukawa M, Ogawa H, Kawase I, Sugiyama H: Wilms tumor gene peptide-based ... Manabu Kawa-kami5, Yoshihiro Oka6, Haruo Sugiyama6 and Masuhiro Takahashi1 1. Laboratory of Hematology and Oncology, Graduate School of Health Sciences, Niigata University, Niigata, ... Hospital Organization, Osaka Minami Medical Center, Osaka, Japan 6. Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Osaka, Japan Corresponding author:...
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Báo cáo y học: "Antibodies to mutated citrullinated vimentin for diagnosing rheumatoid arthritis in anti-CCP-negative patients and for monitoring infliximab therapy" ppt
... Matsui T, Shimada K, Ozawa N, Hayakowa H, Hagiwara F,Nakyama H, Sugii S, Ozawa Y, Tohma S: Diagnostic utility ofanti-cyclic citrullinated peptide antibodies for very early rheu-matoid arthritis. ... formedby post-transcriptional modification of arginine by peptidy-larginine deiminase [5]. Enzyme immunoassays (EIAs) basedon synthetic cyclic citrullinated peptides (CCP2) are availablefor ... Rheuma-tology criteria for RA classification [2]. Two majorACR: American College of Rheumatology; AKA: anti-keratin antibody; APF: anti-perinuclear factor; CCP: cyclic citrullinated peptide; DAS28:...
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