Báo cáo y học: "Effect of adalimumab on neutrophil function in patients with rheumatoid arthritis" pps

... second aim of the study was to determine whether downregulation of phagocyte activities are involved in the anti-inflammatory activity of anti-TNF-α therapy. The lack of activity on phagocytosis, ... insight into a new and interesting mechanism of action of anti-TNF-α mAbs in the control of inflammatory arthritis. Keywords: adalimumab, neutrophils, rheumatoid arthritis...

Ngày tải lên: 09/08/2014, 06:22

... baseline and after 12 months. In one study, one-half of the patients received oral CYC and one-half of the patients were treated with intrave- nous CYC [12]. We analyzed the two cohorts of patients ... appear to result in clinically significant improvement of pulmonary function. Since none of the patients included in these studies were selected on the basis of p...

Ngày tải lên: 09/08/2014, 13:22

... events and withdrawn consent with asenapine, lack of efficacy and withdrawn consent with placebo, and lack of efficacy with olanzapine (Table 1). Efficacy Montgomery-Asberg Depression Rating Scale ... depression receiving quetiapine or in patients with bipolar I depression receiving olanzapine/ fluoxetine [21-23]. They are also within the range of values reported in a meta...

Ngày tải lên: 11/08/2014, 15:22

... citation purposes) Vol 9 No 3 Research article A 1-year case-control study in patients with rheumatoid arthritis indicates prevention of loss of bone mineral density in both responders and nonresponders ... The findings suggest a defect in bone formation that may be explained, in part, by systemic inflamma- tion. Indeed, in one of our previous studies [16], uncoupling...

Ngày tải lên: 09/08/2014, 10:20

... 1 Distribution of X-chromosome inactivation patterns according to age in patients with rheumatoid arthritisDistribution of X-chromosome inactivation patterns according to age in patients with rheumatoid ... 13 years in HT patients and 44.6 ± 14 years in GD patients) . The duration of the symptoms was 7.5 ± 4.6 years among the AITDs patients (6.8 ± 4.8 years in...

Ngày tải lên: 09/08/2014, 14:22

... events con- sisted of skin infections, mostly fungal infections and folliculi- tis. The use of TNF-α-blocking therapy has raised concerns regarding an increased susceptibility to infections, as ... TNF-α-blocking therapy, a finding that could suggest at least a relative contribution to an increased vulner- ability to skin infections in the study population. In one patient, a bacterial...

Ngày tải lên: 09/08/2014, 06:22

... effect of smok- ing on COPD development. Our study highlighted the importance of smoking c essation in t he HIV-positive population in terms of improving lung function and reducing respiratory symptoms, ... signed informed consent, filled out a questionnaire, and under- went spirometry testing. The questionnaire contained information on demography, respirator y symptom s, an...

Ngày tải lên: 10/08/2014, 05:21

... def- initions of an acute exacerbation in the literature vary [2,19,28-30], indicating that there is no clear consensus on the definition of an exacerbation. The application of a different definition of ... Twelve subjects with frequent exacerbations demonstrated a more apparent decline in health status. Conclusion: Although pulmonary function did not significantly decline d...

Ngày tải lên: 18/06/2014, 19:20

... prolonged study interval, then more sub- jects may have experienced exacerbations. Second, concerning the definition of an exacerbation, we selected the definition of an acute exacerbation of ... Twelve subjects with frequent exacerbations demonstrated a more apparent decline in health status. Conclusion: Although pulmonary function did not significantly decline during the 6-month...

Ngày tải lên: 20/06/2014, 16:20

... possibly played by HIV-1 infection. Background Human immunodeficiency virus type-1 (HIV-1) infec- tion is commonly characterized by the presence of a progressive depletion of CD4 + T lymphocytes, ... clinical and laboratory scheduled fol low-up. He discontinued HAART for the onset of lipodistrophy signs, and on July 2009 he returned t o our clinic, showing a worsening of clinical co...

Ngày tải lên: 10/08/2014, 05:22