Báo cáo y học: "The role and clinical implications of G6PI in experimental models of rheumatoid arthritis" pptx
Báo cáo y học: "The role and clinical implications of G6PI in experimental models of rheumatoid arthritis" pptx
... arthritis may be induced by systemic autoreactivity remains interesting and plausible. G6PI- induced arthritis provides a model in which both the induction and modulation of arthritis induced by autoreactivity ... autoimmune disease. Interestingly, although GPI is ubiquitously expressed in the body, the immune response against GPI appears to initiate in the draining lymph nodes...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "The biological and clinical importance of the ‘new generation’ cytokines in rheumatic diseases" pot
... suppression of a variety of models, including CIA and several murine lupus models. Clinical trials directly targeting IL-21 are in pre -clinical planning at this time. The therapeutic utility of this cytokine ... biology and relevant pathophysiology of several novel cytokines present and implicated in synovial processes. Novel interleukin-1-related cytokines The first m...
Ngày tải lên: 09/08/2014, 14:20
Báo cáo y học: "The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis" potx
... 2 Sections of human peri-implant tissues stained by hematoxylin and eosinSections of human peri-implant tissues stained by hematoxylin and eosin. (a) Multinucleated cell associated with a polyethylene ... polyclonal antibodyDetection of β 3 integrin in sections of human peri-implant by immunohistochemistry using a rabbit polyclonal antibody. (a, b) β 3 Integrin is evident in...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection" pptx
... previously [20]. CD4+ T lymphocytes and CD8+ T lymphocytes were defined as CD3+CD4+ and CD3+CD8+ lymphocyte populations, respectively. B lym- phocytes were defined as CD3-CD20+ lymphocytes. NK cells ... activities may play a role in controlling viremia, and that even in the presence of K65R virus, continuation of tenofovir treatment as part of HAART may be beneficial, partic...
Ngày tải lên: 13/08/2014, 09:21
Báo cáo y học: "Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice" ppt
... purposes) induce local injury and participate in the orchestration of systemic inflammation and all of its consequences. ICAM- 1 in particular plays a role in inflammatory processes and in the T ... produced predominantly by activated macrophages and lymphocytes mediate many inflamma- tory processes [49]. These proinflammatory cytokines include interferon-γ (IFN-γ), inte...
Ngày tải lên: 12/08/2014, 18:21
Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the hydrophobicity of the binding site. To ... (k cat /K m )forp-hydroxyphenylgly- cine methyl ester and phenylglycine methyl ester that were similar to the wild-type values, whereas the specificity con- stants for p-hydroxyphenyl...
Ngày tải lên: 17/03/2014, 23:20
Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx
... carboxyl group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparently playing a less important role in side-chain binding. Taken together, the results of this and ... residues in binding the carboxylate linked to the nucleus of penicillin N (Arg160 and Arg162) and the carboxylate of the a-amino- adipoyl side-chain (Arg266). The resul...
Ngày tải lên: 18/03/2014, 01:20
Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt
... evidence for hypoxia in inflammatory and destructive joint disease, and discusses the interplay between alterations in oxygen tension, vascularity and inflammatory signalling pathways. In the present ... vivo in animal models. A clinical trial of 2- methoxyestradiol is planned in RA, and this may yield further insight into the links between hypoxia, angiogenesis, inflam...
Ngày tải lên: 09/08/2014, 01:22
Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc
... [29], in chronically inflamed skin in a Leishmania infection model [30], and in the mucosa and mesenteric lymph nodes in inflammatory colitis in severe combined immunodeficient (SCID) mice [31]. Interestingly, ... allophycocyanine or FITC-conjugated anti-CD25 (PC61), streptavidin-allophycocyanine and streptavidin-PE, and matched antibody pairs for ELISPOT analysis of IFN-γ...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "γ The role of the complement and the FcγR system in the pathogenesis of arthritis" pdf
... granulocytes and particular neutrophils into the synovial lining and fluid and the periarticular spaces. These infiltrating cells produce abundant cytokines, dominated mainly by the inflammatory type ... complement system) in the pathophysiology of immunological diseases. In collagen-induced arthritis (CIA) [7], a model in which arthritis is induced in certain susceptible mous...
Ngày tải lên: 09/08/2014, 06:23