Báo cáo y học: "The role and clinical implications of G6PI in experimental models of rheumatoid arthritis" pptx
Báo cáo y học: "The role and clinical implications of G6PI in experimental models of rheumatoid arthritis" pptx
... arthritis may be induced by systemicautoreactivity remains interesting and plausible. G6PI- induced arthritis provides a model in which both theinduction and modulation of arthritis induced byautoreactivity ... autoimmune disease.Interestingly, although GPI is ubiquitously expressed in thebody, the immune response against GPI appears toinitiate in the draining lymph nodes of peripheral joints in K/B×N mice ... is currently unclear why systemic autoreactivity againstthe ubiquitously expressed glycolytic enzyme G6PI specifically induces arthritis, with no other symptoms of organ-specific or systemic autoimmune...
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Báo cáo y học: "The biological and clinical importance of the ‘new generation’ cytokines in rheumatic diseases" pot
... suppression of a variety of models, including CIA and several murine lupus models. Clinical trials directly targeting IL-21 are in pre -clinical planning at this time.The therapeutic utility of this cytokine ... biology and relevant pathophysiology of several novel cytokines present and implicated in synovialprocesses.Novel interleukin-1-related cytokinesThe first members of the IL-1 family of cytokines ... from experimental models and clinical samples indicate that some of these cytokines contribute to the pathophysiology of arthritis and other inflammatory diseases. Targeting of some of these cytokineshas...
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Báo cáo y học: "The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis" potx
... 2Sections of human peri-implant tissues stained by hematoxylin and eosinSections of human peri-implant tissues stained by hematoxylin and eosin. (a) Multinucleated cell associated with a polyethylene ... polyclonal antibodyDetection of β3 integrin in sections of human peri-implant by immunohistochemistry using a rabbit polyclonal antibody. (a, b) β3 Integrin is evident in the membrane of ... devices of different composition, including polyethyleneFigure 4Detection of cathepsin K mRNA and protein in sections of human peri-implantation tissuesDetection of cathepsin K mRNA and protein in...
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Báo cáo y học: "Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection" pptx
... previously [20]. CD4+ T lymphocytes and CD8+ T lymphocytes were defined as CD3+CD4+ and CD3+CD8+ lymphocyte populations, respectively. B lym-phocytes were defined as CD3-CD20+ lymphocytes. NKcells ... activities may play a role in controlling viremia, and that even in the presence of K65R virus, continuation of tenofovir treatment as part of HAART may be beneficial,particularly when assisted by antiviral ... J Infect Dis 2005, 192:456-465.67. Khanlou H, Yeh V, Guyer B, Farthing C: Early virologic failure in a pilot study evaluating the efficacy of therapy containingonce-daily abacavir, lamivudine,...
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Báo cáo y học: "Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice" ppt
... purposes)induce local injury and participate in the orchestration of systemic inflammation and all of its consequences. ICAM-1 in particular plays a role in inflammatory processes and in the T ... produced predominantly by activatedmacrophages and lymphocytes mediate many inflamma-tory processes [49]. These proinflammatory cytokinesinclude interferon-γ (IFN-γ), interleukin-1 (IL-1), tumournecrosis ... AL, Szabó C:Anti-inflammatory effects of mercaptoethylguanidine, acombined inhibitor of nitric oxide synthase and peroxyni-trite scavenger, in carrageenan-induced models of inflammation. Free...
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Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... and volume of the acyl binding pocket and thereby alter the binding mode and affinity of theenzyme for PAA and derivatives thereof, while maintainingthe hydrophobicity of the binding site.To ... (kcat/Km)forp-hydroxyphenylgly-cine methyl ester and phenylglycine methyl ester that weresimilar to the wild-type values, whereas the specificity con-stants for p-hydroxyphenylglycine amide and phenylglycineamide ... methyl ester or the amide asacyl donor.It appeared that 6-APA and 7-ADCA were able toefficiently deacylate the phenylglycyl- and p-hydroxyphe-nylglycyl-enzyme of bF24A, as indicated by, respectively,...
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Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx
... carboxyl group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparentlyplaying a less important role in side-chain binding. Takentogether, the results of this and ... residues in binding the carboxylate linked to the nucleus of penicillin N(Arg160 and Arg162) and the carboxylate of the a-amino-adipoyl side-chain (Arg266). The results for mutation of Arg74 and ... ternary com-plex to oxygen binding, thereby initiating catalysis and ensuring coupling of 2-oxoglutarate conversion to primesubstrate oxidation. In the case of DAOCS it has been previously shown...
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Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt
... evidence for hypoxia in inflammatory and destructive joint disease, and discusses theinterplay between alterations in oxygen tension, vascularity and inflammatory signalling pathways. In the present ... vivo in animal models. A clinical trial of 2-methoxyestradiol is planned in RA, and this may yield furtherinsight into the links between hypoxia, angiogenesis,inflammatory cell trafficking and ... intracellulardomain of the Notch receptor (involved in the maintenance of cells in an undifferentiated state), both of which notablycontain ankyrin repeat motifs containing the asparagineresidue hydroxylated...
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Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc
... [29], in chronically inflamed skin in a Leishmaniainfection model [30], and in the mucosa and mesentericlymph nodes in inflammatory colitis in severe combinedimmunodeficient (SCID) mice [31]. Interestingly, ... allophycocyanine or FITC-conjugatedanti-CD25 (PC61), streptavidin-allophycocyanine and streptavidin-PE, and matched antibody pairs for ELISPOTanalysis of IFN-γ (R4-6A2 and biotinylated XMG1.2) and ... with111 In and injected intravenously into AIA mice 7 days afterFigure 3Analysis of in vivo and ex vivo immune responses in CD25-depleted miceAnalysis of in vivo and ex vivo immune responses in CD25-depleted...
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Báo cáo y học: "γ The role of the complement and the FcγR system in the pathogenesis of arthritis" pdf
... granulocytes and particular neutrophils into the synovial lining and fluid and theperiarticular spaces. These infiltrating cells produce abundantcytokines, dominated mainly by the inflammatory type ... complementsystem) in the pathophysiology of immunological diseases. In collagen-induced arthritis (CIA) [7], a model in which arthritisis induced in certain susceptible mouse strains by injectingcollagen ... Arthusreaction either by activation of the complement system or bythe direct engagement and activation of FcγR-bearinginflammatory cells. Complement and FcγRs act in concert in many inflammatory responses,...
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