Báo cáo y học: "JNK1 is not essential for TNF-mediated joint disease" doc

... investigated the role of JNK1 in TNF-mediated inflam- matory joint disease. Our findings show that the JNK1 sig- nal pathway is not essential for the development of arthritis and joint destruction. Materials ... toluidine blue for tartrate-resistant acid phos- phatase (TRAP) activity. TRAP staining was performed as previously described [13]. For immunohistochemistry, deparaf...

Ngày tải lên: 09/08/2014, 06:22

... the COX-2 isoform is inducible under pathophysiological, mainly inflammatory, conditions [2]. Consequently, the current pharmacological strategy is to selectively inhibit COX-2 and thereby avoid ... synoviocytes One mechanism that is consistently implicated in apoptosis is the activation of a cascade of cytosolic proteases called cas- pases. Caspases are synthesized as inactive proenz...

Ngày tải lên: 09/08/2014, 10:22

... AKI was defined by using Letter RIFLE is not RIFLE: on the comparability of results Lars Englberger, Rakesh M Suri and Hartzell V Schaff Division of Cardiovascular Surgery, Mayo Clinic, Rochester, ... definition of acute kidney injury (urinary output criteria not listed) RIFLE class RIFLE criteria R (risk) ≥1.5-fold increase in serum creatinine, or >25% decrease in GFR I (injury) ≥2...

Ngày tải lên: 13/08/2014, 20:21

... for Surgeons) taxonomy identified by University of Aberdeen Industrial Psychology Research Centre. This taxonomy is being used in the training of sur- geons in non-technical skills by The Royal ... the team. However, they wanted the feedback dis- tinct and clear. An experienced surgeon told us that he is always ready for suggestions, but he was not always ready to discuss the sugges...

Ngày tải lên: 13/08/2014, 23:20

Ngày tải lên: 13/08/2014, 20:21

... lung injury pattern and a ‘one size fi ts all’ PEEP titration strategy may be not be adequate for all patients. For a given level of PEEP, transpulmonary pressures may vary widely from patient ... strategy using esophageal pressures to titrate PEEP improves arterial oxygenation and lung compliance. However, since improved oxygenation is not a surrogate end point for mortalit...

Ngày tải lên: 13/08/2014, 21:21

... even distribution of weight across the disc, with sub- sequent relief of discogenic pain. PLDD is performed most commonly for lumbar disc disease, and pub- lished reports on the efficacy of PLDD ... pneumothorax, pleurisy, and spondylodiscitis. Long-term outcome was not reported and thus it is unknown if their results extended beyond the study period of 6 weeks. In our study, s...

Ngày tải lên: 26/10/2012, 09:07

... Human Lung Tissue Cells. J Immunol 2010. 46. Kondo Y, Yoshimoto T, Yasuda K, Futatsugi-Yumikura S, Morimoto M, Hayashi N, Hoshino T, Fujimoto J, Nakanishi K: Administration of IL-33 induces airway hyperresponsiveness ... MY, Huang FP, Ip WK, Lo Y, Wong FY, Chan EY, Lam KF, Xu D: Serum levels of IL-33 and soluble ST2 and their association with disease activity in systemic lupus erythematosus...

Ngày tải lên: 11/08/2014, 03:20

... mutation rate for diseases. Mutation rates vary considerably by type, particularly for viruses [33]. Decay of immunity is modeled, and immu- nity decay can act as a fair surrogate for antigenic ... simulation display for a city of 350,000 peopleFigure 2 (Clockwise, a, b, c d) – Part of a multi-year simulation display for a city of 350,000 people. (2a., 2b.) Two alternative display...

Ngày tải lên: 13/08/2014, 23:20

... concentrations: 50 l M for ALLN, 50 l M for Lactacystin (Lacta), 20 m M for NH 4 Cl and 200 l M for chloroquine (Chloro)]. Cells were lysed and the quantity of protein measured by Bradford assay. 10 lg of ... proteins Ub is highly conserved among eukaryotes, as only three of 76 amino acids differ between the human and yeast proteins. Therefore, Ub is not an optimal antigen and a...

Ngày tải lên: 17/03/2014, 23:20