Báo cáo y học: "Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation" pps
Báo cáo y học: "Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation" pps
... articleGene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammationVyacheslav A Adarichev1, Csaba Vermes1, Anita Hanyecz1, Katalin Mikecz1, ... gene expression profile is extremely complexowing to the diversity of cell types involved in the pathology and the polygenic character of the autoimmune disease [1-5]. The overall picture of ... compounds to induce arthritis [6,21-23]. Despite the usefulness of the information provided by these studies, the early gene expression events at the site of inflammation (joint and synovium) and the...
- 12
- 546
- 0
Báo cáo y học: "Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis" doc
... berepresentative of the globality of the slide. The surface staining(S) and the surface of the nuclei (N) were determined for eachimage, and the area of staining then was normalized by calcu-lating the ... allowed during the duration of the study.Adalimumab therapy was initiated at a dosage of 40 mg sub-cutaneously every other week. Disease activity at baseline (T0) and 12 weeks after initiation of therapy ... - Ctactin;ΔΔCt values then were obtained by subtracting the ΔCt of areference sample from the ΔCt of the studied samples. Finally, the levels of expression of the target genes in the studied...
- 13
- 486
- 0
Báo cáo y học: "Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis" docx
... severity and/ or susceptibility to arthritis in this animal model. Of particular interest is KDAP (napsin)because of the high fold increase in gene expression observed in arthritic joints from SCW-injected ... whose expression is associ-ated with onset and progression of arthritis pathology in ratjoints from the reactivation model of SCW-induced arthritis in Lewis (LEW/N) rat. This transcript profiling ... grouped by their general ontology and clustered based on their similarity in terms of pattern of expression (C) and expression level (I). Data are expressed as the mean fold increase in gene expression...
- 17
- 487
- 0
Báo cáo y học: "Degradome expression profiling in human articular cartilage" potx
... func-tion of each of these enzymes, although they are presumed tobe active predominantly intracellularly [26,27]. Cathepsin H,cathepsin C, cathepsin F, cathepsin W, cathepsin B and cathepsin S are ... level of expression in cartilage, as well as a robust and significant increase in expression in OA. Cathepsin K is the only vertebrate enzyme outside the MMP family capable of degrading the collagen ... helped in collecting and processing tissue samples, and advised running and inter-preting low-density arrays. CJP and XSP designed the low-density arrays. CD and AC took patient consent and coordi-nated...
- 14
- 251
- 0
Báo cáo y học: "Gene expression profiles in BCL11B-siRNA treated malignant T cells" ppt
... downregulated by 3-4 fold. The expres-sion levels of SPP1andCREBBP genes involved in the transforming growth factor (TGF-b) pathway were downby 16 fold. The changes in the expression levels of the Huang ... The BH3-only domain proteins BIK and BNIP3, which werelocated upstream of BCL-2 (Figure 2), may enhancetheir binding to BCL-2, thereby inhibiting the anti-apop-totic function. Thus, we analyzed the ... was identified in the microarrayanalysis, but not confirmed by real-time PCR analysis. The reason may be due to a systemic error on the microarr ay analysis. Interestingly, unlike the result fromMolt-4...
- 6
- 328
- 0
Báo cáo Y học: Extra terminal residues have a profound effect on the folding and solubility of a Plasmodium falciparum sexual stage-specific protein over-expressed in Escherichia coli pptx
... protein quality between Pfg27A and the rest of the constructs was retained. Therefore, the differing proteinsolubilities were inherent in the constructs and could not bemodulated by varying the ... proteins were expressed and purified. Our results show that the fusion proteins werelabile and only partially soluble in five of the constructsresulting in very poor yields. Intriguingly, in the ... highlight the central issue that solubility of fusion proteins is not necessarily indicative of either properfolding or of increased solubility of the protein of interest.We propose that the success...
- 5
- 435
- 0
Báo cáo khoa học: Comparative proteomic analysis identifies proteins associated with the development and progression of colorectal carcinoma pot
... S100A9 and LASP-1 may play animportant role in the development and progression of CRC. Further functional and clinical analysis of the proteins is necessary to elucidate their precise role in the ... in the cytosol. Moreover, they interactonly with prenylated Rho proteins both in vitro and in vivo [11,12]. They also inhibit nucleotide exchange and GTP-hydrolyzing activities on Rho proteins ... proteins involved in protein synthesis and folding (heat shock proteins),cell communication and signal transduction (annexin),cellular reorganization and the cytoskeleton (tropo-myosin, tubulin...
- 10
- 366
- 0
Báo cáo y học: "Gene expression induced by interleukin-17 in fibroblast-like synoviocytes of patients with rheumatoid arthritis: upregulation of hyaluronan-binding protein TSG-6" doc
... K:Elevation of interleukin-8 (IL-8) levels in joint fluids of patientswith rheumatoid arthritis and the induction by IL-8 of leuko-cyte infiltration and synovitis in rabbit joints. LymphokineCytokine ... The interaction of the cytokines IL-1β, IL-17, and TNF-α sus-tained inflammatory processes within the joint and amplified the involvement of T cells in the pathogenesis of RA.We and others have ... alone and also in combination to induce the syn-thesis of IL-6, IL-8, and TSG-6 by SFCs. The three cytokinesactivate the common transcription factor NF-κB in SFCs and in a variety of other cell...
- 7
- 323
- 0
Báo cáo y học: "Gene expression signatures for autoimmune disease in peripheral blood mononuclear cells" potx
... findings extended those of other groups (working in MS and SLE) by including patients with RA and IDDM, and by offering direct comparisons between them. The similar gene expression findings in ... methodology might be especiallyuseful in analyzing the complex and parallel changes thatoccur within cells and tissues of the immune system in normal and pathologic states [2]. Much of the early workusing ... portion of the differentially expressed genes in the autoimmune signature, suggesting that this single gene may be centralto the autoimmune state. In other ongoing studies we haveconfirmed, by independent...
- 9
- 428
- 0
Báo cáo y học: "Gene expression and activity of cartilage degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblast" potx
... chemokines [13].There is increasing evidence that SFs are key players in the pathogenesis of RA by invading and eroding hyaline cartilage.SFs, activated locally, produce a variety of cytokines, ... the SMs may be explained either byinhibition of its expression within the synovium or by upregula-tion of it by factors during in vitro growth of fibroblasts.Figure 6Gene expression of synovial ... matrix.One of the most striking findings of our study was that the reg-ulation of gene expression of glycosidases and proteases bycytokines seems to be discordant. In sharp contrast to MMPs and other...
- 13
- 681
- 1
Từ khóa: Một số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngChuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM