Báo cáo y học: "Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation" pps

... article Gene expression profiling in murine autoimmune arthritis during the initiation and progression of joint inflammation Vyacheslav A Adarichev 1 , Csaba Vermes 1 , Anita Hanyecz 1 , Katalin Mikecz 1 , ... gene expression profile is extremely complex owing to the diversity of cell types involved in the pathology and the polygenic character of the...

Ngày tải lên: 09/08/2014, 06:22

... be representative of the globality of the slide. The surface staining (S) and the surface of the nuclei (N) were determined for each image, and the area of staining then was normalized by calcu- lating the ... allowed during the duration of the study. Adalimumab therapy was initiated at a dosage of 40 mg sub- cutaneously every other week. Disease activity a...

Ngày tải lên: 09/08/2014, 14:20

... severity and/ or susceptibility to arthritis in this animal model. Of particular interest is KDAP (napsin) because of the high fold increase in gene expression observed in arthritic joints from SCW-injected ... whose expression is associ- ated with onset and progression of arthritis pathology in rat joints from the reactivation model of SCW-induced arthritis...

Ngày tải lên: 09/08/2014, 06:22

... func- tion of each of these enzymes, although they are presumed to be active predominantly intracellularly [26,27]. Cathepsin H, cathepsin C, cathepsin F, cathepsin W, cathepsin B and cathepsin S are ... level of expression in cartilage, as well as a robust and significant increase in expression in OA. Cathepsin K is the only vertebrate enzyme outside the MMP family ca...

Ngày tải lên: 09/08/2014, 14:22

... downregulated by 3-4 fold. The expres- sion levels of SPP1andCREBBP genes involved in the transforming growth factor (TGF-b) pathway were down by 16 fold. The changes in the expression levels of the Huang ... The BH3-only domain proteins BIK and BNIP3, which were located upstream of BCL-2 (Figure 2), may enhance their binding to BCL-2, thereby inhibiting the anti-a...

Ngày tải lên: 10/08/2014, 21:23

... protein quality between Pfg27 A and the rest of the constructs was retained. Therefore, the differing protein solubilities were inherent in the constructs and could not be modulated by varying the ... proteins were expressed and purified. Our results show that the fusion proteins were labile and only partially soluble in five of the constructs resulting in very p...

Ngày tải lên: 23/03/2014, 21:20

... S100A9 and LASP-1 may play an important role in the development and progression of CRC. Further functional and clinical analysis of the proteins is necessary to elucidate their precise role in the ... in the cytosol. Moreover, they interact only with prenylated Rho proteins both in vitro and in vivo [11,12]. They also inhibit nucleotide exchange and GTP-hydro...

Ngày tải lên: 23/03/2014, 03:20

... K: Elevation of interleukin-8 (IL-8) levels in joint fluids of patients with rheumatoid arthritis and the induction by IL-8 of leuko- cyte infiltration and synovitis in rabbit joints. Lymphokine Cytokine ... The interaction of the cytokines IL-1β, IL-17, and TNF-α sus- tained inflammatory processes within the joint and amplified the involvement of T cells...

Ngày tải lên: 09/08/2014, 01:22

... findings extended those of other groups (working in MS and SLE) by including patients with RA and IDDM, and by offering direct comparisons between them. The similar gene expression findings in ... methodology might be especially useful in analyzing the complex and parallel changes that occur within cells and tissues of the immune system in normal and pathologic...

Ngày tải lên: 09/08/2014, 01:23

... chemokines [13]. There is increasing evidence that SFs are key players in the pathogenesis of RA by invading and eroding hyaline cartilage. SFs, activated locally, produce a variety of cytokines, ... the SMs may be explained either by inhibition of its expression within the synovium or by upregula- tion of it by factors during in vitro growth of fibroblasts. Figure 6...

Ngày tải lên: 09/08/2014, 14:20