Báo cáo y học: "Toll-like receptor downstream signaling" ppt

Báo cáo y học: "Antigen receptor signaling in the rheumatic diseases" doc

Báo cáo y học: "Antigen receptor signaling in the rheumatic diseases" doc

... functional studies of primary human lymphocytes and recent advances in human genetics. B-cell receptor hyper-responsiveness is identified as a nearly universal characteristic of systemic lupus erythema- tosus ... are phosphorylated by the Src family kinases (SFKs), which, in T cells, are Lck and Fyn. Dually phosphorylated ITAMs, in turn, form docking sites for the tandem SH2 domains of Syk...

Ngày tải lên: 09/08/2014, 01:22

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Báo cáo Y học: Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin potx

Báo cáo Y học: Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin potx

... NRG1-b1. Activation of downstream ERK by the chimeric receptors To determine whether the receptor phosphorylation triggers the activation of downstream cellular pathways, the chimeric receptors were ... Suehiro-cho, Tsurumi, Yokohama, Japan; 3 Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan A series of chimeric r...

Ngày tải lên: 24/03/2014, 03:21

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Báo cáo Y học: Nuclear receptor-dependent transcription with chromatin Is it all about enzymes? pot

Báo cáo Y học: Nuclear receptor-dependent transcription with chromatin Is it all about enzymes? pot

... coactivator complexes contain histone modifying enzymes (e.g. acetylases, deacetylases, methyl- transferases, and kinases) that covalently modify specific lysine, arginine, or serine residues in the ... many of them have recently been reviewed elsewhere [15]. CHROMATIN MODIFYING ENZYMES AND THE REPRESSION OF TRANSCRIPTION BY NRs Histone deacetylases (HDACs) Many class II NRs, including thyroid...

Ngày tải lên: 31/03/2014, 21:21

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Báo cáo y học: " Phosphatidylserine receptor and apoptosis: consequences of a non-ingested meal" pptx

Báo cáo y học: " Phosphatidylserine receptor and apoptosis: consequences of a non-ingested meal" pptx

... with the hypothesis that when cells undergoing apoptosis are not properly cleared, they may enter late stages of apoptosis and secondary necrosis consecutively. The membranes of the dying cells became ... 302:1563-1566. 10. Kunisaki Y, Masuko S, Noda M, Inayoshi A, Sanui T, Harada M, Sasazuki T, Fukui Y: Defective fetal liver erythropoiesis and T- lymphopoiesis in mice lacking phosphatidyls...

Ngày tải lên: 09/08/2014, 01:23

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Báo cáo y học: "Estrogen receptor-α gene haplotype is associated with primary knee osteoarthritis in Korean population" docx

Báo cáo y học: "Estrogen receptor-α gene haplotype is associated with primary knee osteoarthritis in Korean population" docx

... article Estrogen receptor- α gene haplotype is associated with primary knee osteoarthritis in Korean population Sheng-Yu Jin *1 , Seung-Jae Hong *2 , Hyung In Yang 3 , Sang-do Park 3 , Myung-Chul Yoo 4 , ... primary knee OA. Genotypes of the ER-α gene polymorphism were determined by PCR followed by restriction enzyme digestion (PvuII for intron 1 T/C, XbaI for intron 1 A/G, and BtgI for exo...

Ngày tải lên: 09/08/2014, 01:23

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Báo cáo y học: "Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis" ppt

Báo cáo y học: "Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis" ppt

... Nakajima 5,6 , Peter E Lipsky 7 and Nobuyuki Miyasaka 1,8 1 Departments of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113- 8519, Japan 2 Department ... Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan 3 Department of Pediatrics and Developmental Biology, Graduate School, Tokyo Medi...

Ngày tải lên: 09/08/2014, 14:22

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Báo cáo y học: " Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India" potx

Báo cáo y học: " Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India" potx

... HIV-1 subtype C V3 sequence may reduce the possibility of co -receptor switch in subtype C viruses and may partially explain the low prevalence of X4-tropic strains. An additional contributory factor ... major cellular receptor for HIV entry [1,2], multiple studies suggested the presence of a secondary cellular receptor for HIV entry into the human CD4 cell [3,4]. These co- receptors, pa...

Ngày tải lên: 10/08/2014, 05:21

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Báo cáo y học: " Involvement of mTOR signaling in sphingosylphosphorylcholine-induced hypopigmentation effects" pps

Báo cáo y học: " Involvement of mTOR signaling in sphingosylphosphorylcholine-induced hypopigmentation effects" pps

... signaling in sphingosylphosphorylcholine-induced hypopigmentation effects Hyo-Soon Jeong 1 , Seung Hoon Lee 1 , Hye-Young Yun 1 , Kwang Jin Baek 1 , Nyoun Soo Kwon 1 , Kyoung-Chan Park 2 and ... pro- duced by melanoc ytes and its synthesis is promoted by various stimulators such as UV irradiation, hormones, and cytokines [1-3]. At least 3 enzymes are required for melanin synthesis. Tyrosinase...

Ngày tải lên: 10/08/2014, 10:20

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Báo cáo y học: " Lipopolysaccharide-induced Notch signaling activation through JNK-dependent pathway regulates inflammatory response." potx

Báo cáo y học: " Lipopolysaccharide-induced Notch signaling activation through JNK-dependent pathway regulates inflammatory response." potx

... IL-6) and late inflammatory cytokines (VEGF and HMGB1), but not of an early inflammatory cytokine (TNF-a). This result is reasonable because DAPT can only prevent the cytokine response at 3 hours ... N-[N-(3,5-difluorophenacetyl)-L-alanyl]-(S)-phenylgly cine-t- butyl ester. Acknowledgements We thank the Second Core Laboratory of the Department of Medical Research of the National Taiwan Univer...

Ngày tải lên: 10/08/2014, 10:20

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Báo cáo y học: "Epigenetics, Behaviour, and Health" ppt

Báo cáo y học: "Epigenetics, Behaviour, and Health" ppt

... by DNA methylation is a common mechanism in cancer. 36 DNA Methylation Enzymes The DNA methylation pattern is not copied by the DNA replication machinery but by independent enzymatic machinery, ... embryos promote an active demethylation of DNA by excision repair of 5-methyldeoxycyti- dine. Proc Natl Acad Sci U S A 1993;90:4684–8. 50. Zhu B, Zheng Y, Hess D, et al. 5-Methylcytosine-DNA glyco...

Ngày tải lên: 08/08/2014, 21:20

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