Báo cáo y học: "A2B adenosine receptor activity is reduced in neutrophils from patients with systemic sclerosis" ppt

... SSc. Keywords: adenosine, A 2 adenosine receptors, neutrophils, receptor binding, systemic sclerosis Introduction Systemic sclerosis (SSc), also known as scleroderma, is a connective tissue disease ... described in patients with SSc, suggesting an alteration in adenosine control mechanisms in this disease [16,17]. In the present study we analyzed A 2A and A 2B AR s...

Ngày tải lên: 09/08/2014, 06:22

... transcript, leading to in- frame deletion of an amino acid, p.Ser95del, in the elastin/laminin-binding domain of EBP. This variation i n the elastin-binding domain of the EBP protein may directly impair ... usually occurring within the first two years of life. Cardiomyopathy is an atypical clinical feature in some Caucasian patients with infantile GM1 gangliosido- sis. The residual...

Ngày tải lên: 10/08/2014, 05:21

... clinical manifestations or laboratory profiles. In our study, the BB genotype is low in both 194 healthy controls and 101 patients with SLE. However, this is in accordance with previous findings ... arthritis [4] and rheuma- toid arthritis [5]. Polymorphism of the vitamin D receptor (VDR) gene was found to be associated with many diseases, including oste- oporosis [6], hyp...

Ngày tải lên: 09/08/2014, 07:20

... apoptosis. TCDD induces nPKC kinase activity in L-MAT cells To establish whether TCDD increases nPKC kinase activity, we examined nPKC kinase activity by using PKCh pseudo-substrate, which is preferentially ... induced by TCDD was com- pletely inhibited in the presence of 20 lm myr-PKCh PPI, as shown in Fig. 4, confirming the involvement of nPKCs. PKCh kinase activity is compl...

Ngày tải lên: 23/03/2014, 13:20

... the pathophysiology of allergic rhinitis or its relationships with asthma. Trial registration: ClinicalTrials.gov NCT01286129 Background Asthma and rhinitis are two airway inflammatory dis- eases ... response in this study. Conclusions This study shows that multiple nasal challenges with perennialallergensinducemorerhinorrheainrhinitic subjects without asthma and more nasal obstruction...

Ngày tải lên: 08/08/2014, 21:20

... positive symptoms. This may be intriguing in view of the evidence, from a pos- itron emission tomography (PET) study, showing dysreg- ulation of dopaminergic transmission in the midbrain in schizophrenia ... be significantly correlated with the reduced GM volume in the bilateral posterior cingulate gyrus, with the increased WM volume in the cerebellum (vermis region), and w...

Ngày tải lên: 08/08/2014, 23:21

... detect and/or treat predisposing factors such as vitamin D deficiency, which is commonly found in this type of patient. The majority of the 1,497 minor injuries consisted of bruising (40%), wounds ... Ozanne-Smith J: Injury risk in young people with intellectual disability. J Intellect Disabil Res 2002, 46:6-16. 10. Konarski EA, Sutton K, Huffman A: Personal characteristics associate...

Ngày tải lên: 08/08/2014, 23:21

... 0.06). Discussion Our study shows that hyperhemia to local heating is dramati- cally altered in terms of kinetics and amplitude in patients with SSc in comparison with patients with primary RP, ... prospectively discriminate those patients presenting with RP who will develop clinical signs of connective tissue diseases. We are also planning a study to include patients...

Ngày tải lên: 09/08/2014, 06:23

... defect from patients in the late stages of OA, an increase in staining intensity was found in the pericel- lular space (Figure 4b). In healthy cartilage, COMP staining was also found in the territorial ... observed with COMP in other instances. The smear in the blot of healthy cartilage tissue (Fig- ure 2, lane 3) probably results from the high aggrecan content, which i...

Ngày tải lên: 09/08/2014, 07:20

... 2 Synovial fluid neutrophil and lymphocyte apoptosis in patients with very early inflammatory arthritisSynovial fluid neutrophil and lymphocyte apoptosis in patients with very early inflammatory ... 1 Apoptotic lymphocytes and neutrophils in synovial fluid cytospin preparations from patients with very early inflammatory arthritisApoptotic lymphocytes and neutrophils i...

Ngày tải lên: 09/08/2014, 08:22