Báo cáo y học: "Local expression of matrix metalloproteinases, cathepsins, and their inhibitors during the development of murine antigen-induced arthritis" pps
Báo cáo y học: "Local expression of matrix metalloproteinases, cathepsins, and their inhibitors during the development of murine antigen-induced arthritis" pps
... chip analysis. US, NS and CP analysed the MMP, cathepsin and cytokine expres-sion by real-time PCR. MH performed the zymography, the MMP activity assay and the cytokine ELISAs. US wrote the manuscript. ... Like the expression of cathepsins, the expression of cystatin B wasstrongest on day 3 (Fig. 3a).MMP measurement by fluorescence activity assay and zymographyFluorescence assay data of MMP ... levels of pro-inflammatory cytokines on days 1 and 3. The downregula-tion of cathepsin K on day 1 could be another example of the fact that the time course of cytokine expression determines the...
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Báo cáo y học: "Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect" pdf
... in the brain, the lung, the liver, the kidney, and the spleen [30]. Furthermore, our in vivo imaging system could notbe detected in any other organs expect the knee whenluciferase-positive synovial ... obvious features of hydrar-throsis or synovial proliferation. Mild spur formation wasobserved on the edge of the trochlear groove of the femur insome samples of the control group, but there were ... of more cells wouldincrease the number of cells that adhered to the defect; how-ever, the injection of a large number of cells would alsoincrease the number of cells that adhered to the synovium,thereby...
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Tài liệu Báo cáo Y học: Granule-bound starch synthase I A major enzyme involved in the biogenesis of B-crystallites in starch granules ppt
... course of storage starch synthesis show that amylopectin and amylosesynthesis are partly disconnected and that amylose synthesispersists when the rate of polysaccharide and amylopectinsynthesis ... followed the kinetics of amylose synthesis overa 5-day period of nitrogen starvation and measured the amounts of starch, amylose, the kmax of the starchfractions, the degree of crystallinity and the ... issynthesized in vivo when the rate of amylopectin synthesisbecomes minimal. At these moments the rates of amylopec-tin synthesis are only 5% of their maximal values. In fact thislow rate of...
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Báo cáo Y học: Cytochrome c from a thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability potx
... purified and handled more easilythan their mesophilic counterparts. Although thermophilicFig. 4. Thermal stability of wild-type PA c-551, the quintuple mutant, and HT c-552. The heat capacity curves ... T., Yamazaki, K., Kyogoku, Y. &Kobayashi, Y. (1998) Solution structure of thermostable cyto-chrome c-552 from Hydrogenobacter thermophilus determined by1H-NMR spectroscopy. Biochemistry ... two cysteine residues in the consensus Cys-X-X-Cys-His motif [1–4]. Site-directed mutagenesis studies of cytochrome c are at a relatively early stage, because of the difficulty of expressing the...
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Báo cáo y học: "Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity" pps
... supports both of thesepredictions. At the same time the model explains why, para-doxically, some type of T cell-B cell contact is required in the development of autoimmunity. Finally, the model ... immune sys-tem is further amplified by the results of the analysis of MHC IIT cell epitopes using the ProPred server shown in Fig. 5b.Here we can see that the extremely disordered regions of the virus ... attack, ini-tially on similar sequences in the B/B' polypeptide followed byspreading to the rest of the Sm particle.To further explore the relevance of disorder to the idea of spreading we...
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Báo cáo y học: "THR0921, a novel peroxisome proliferator-activated receptor gamma agonist, reduces the severity of collagen-induced arthritis" pps
... initiate the inflammatory process and are the source of manycytokines responsible for cartilage and bone loss, this may bea primary mechanism by which THR0921 provides clinicalbenefit. The effect of ... THR0921 and other PPARγ ligands maybe due to their ability to inhibit the activity of key transcriptionfactors such as activator protein-1 (AP-1) and nuclear factorκB [35,36]. As such, targeted therapy ... synovium; 1, synovial membrane hypertrophy and cell infiltrates; 2, pannus and cartilage erosions, 3, majorerosions of cartilage and subchondral bone; and 4, loss of joint integrity and ankylosis....
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Báo cáo y học: "Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer''''s patches in an orally tolerized, collagen-induced arthritis mouse model" ppt
... and erythema from the ankle to the tarsal bone,3 = moderate edema and erythema from the ankle to the tarsalbone, and 4 = edema and erythema from the ankle to the entireleg. The sum of the values ... H-SP, Y- OJ, and S-HC performed the experimen-tal work H-YK is the head of the laboratory, supervised the experimental work, and advised on the study. S-HP, and J-KMare the senior researchers, and ... induced by classicalDC maturation stimuli, namely IFNγ and lipopolysaccharide orprostaglandin E2, which contribute to their immunoregulatorycapacity [37-40]. In our study, the phenotype of DCs...
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Báo cáo y học: " High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease." docx
... perspective on the dynamics of thesemolecules inside the cell and the diversity of activities thatthese molecules display once they are outside.Competing interests The authors declare that they have ... tissuedamage and to trigger an immediate response. A key facet of the biology of alarmins is therefore their translocation from the inside to the outside of the cell [1]. During the past decade, ... [26]. Thus, HMGB1 may act synergistically withother immunostimulatory molecules to modulate their interaction with cells and amplify their activity because of their physical association (Figure...
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Báo cáo y học: "Genomic transcriptional profiling identifies a candidate blood biomarker signature for the diagnosis of septicemic melioidosis" ppsx
... (HMFN0839)* 1-Acylglycerol-3-phosphate O-acyltransferase 9 [GenBank:NM_032717.3]34 MTHFD2 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase[GenBank:NM_006636.3]35 ... in the same cluster in eight of the eight groups). The selection was then expanded to include genes with 7 of 8, 6 of 8 and 5 of 8 matches to the core reference pattern. The result-ing set of ... network analysis of the 37 classifiers. (a) The 37 classifiers were analyzed using ingenuity pathway analysis and the classifiers were grouped to 12 canonical biological process pathways. The antigen...
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Báo cáo y học: " Protein kinase A-dependent Neuronal Nitric Oxide Synthase Activation Mediates the Enhancement of Baroreflex Response by Adrenomedullin in the Nucleus Tractus Solitarii of Rats" pps
... microinjection of the test agent into NTS. The BRR response was represented by the ratio of the peak magnitude of reflex bradycardia to the peak magni-tude of phenylephrine-induced pressor response. The averaged ... out the neurophysiologic and neuropharmacologic studies, and performed the Western blotting analysis. YJL and ICC participated in the interpretation of data and performed the statistical analysis. ... University, Taipei, Taiwan.Authors’ contributionsDHTY and LCC participated in the design of this study and helped to draft the manuscript. YCS carried out the immunohistochemical experiments. YCCand...
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Từ khóa: Nghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ