Báo cáo y học: "Local expression of matrix metalloproteinases, cathepsins, and their inhibitors during the development of murine antigen-induced arthritis" pps

... chip analysis. US, NS and CP analysed the MMP, cathepsin and cytokine expres- sion by real-time PCR. MH performed the zymography, the MMP activity assay and the cytokine ELISAs. US wrote the manuscript. ... Like the expression of cathepsins, the expression of cystatin B was strongest on day 3 (Fig. 3a). MMP measurement by fluorescence activity assay and zymogr...

Ngày tải lên: 09/08/2014, 06:22

... in the brain, the lung, the liver, the kidney, and the spleen [30]. Furthermore, our in vivo imaging system could not be detected in any other organs expect the knee when luciferase-positive synovial ... obvious features of hydrar- throsis or synovial proliferation. Mild spur formation was observed on the edge of the trochlear groove of the femur in some samples of...

Ngày tải lên: 09/08/2014, 10:23

... course of storage starch synthesis show that amylopectin and amylose synthesis are partly disconnected and that amylose synthesis persists when the rate of polysaccharide and amylopectin synthesis ... followed the kinetics of amylose synthesis over a 5-day period of nitrogen starvation and measured the amounts of starch, amylose, the k max of the starch fractions...

Ngày tải lên: 22/02/2014, 07:20

... purified and handled more easily than their mesophilic counterparts. Although thermophilic Fig. 4. Thermal stability of wild-type PA c-551, the quintuple mutant, and HT c-552. The heat capacity curves ... T., Yamazaki, K., Kyogoku, Y. & Kobayashi, Y. (1998) Solution structure of thermostable cyto- chrome c-552 from Hydrogenobacter thermophilus determined by 1 H-NMR spectros...

Ngày tải lên: 24/03/2014, 03:21

... supports both of these predictions. At the same time the model explains why, para- doxically, some type of T cell-B cell contact is required in the development of autoimmunity. Finally, the model ... immune sys- tem is further amplified by the results of the analysis of MHC II T cell epitopes using the ProPred server shown in Fig. 5b. Here we can see that the extre...

Ngày tải lên: 09/08/2014, 07:20

... initiate the inflammatory process and are the source of many cytokines responsible for cartilage and bone loss, this may be a primary mechanism by which THR0921 provides clinical benefit. The effect of ... THR0921 and other PPARγ ligands may be due to their ability to inhibit the activity of key transcription factors such as activator protein-1 (AP-1) and nuclear facto...

Ngày tải lên: 09/08/2014, 07:20

... and erythema from the ankle to the tarsal bone, 3 = moderate edema and erythema from the ankle to the tarsal bone, and 4 = edema and erythema from the ankle to the entire leg. The sum of the values ... H-SP, Y- OJ, and S-HC performed the experimen- tal work H-YK is the head of the laboratory, supervised the experimental work, and advised on the study...

Ngày tải lên: 09/08/2014, 10:22

... perspective on the dynamics of these molecules inside the cell and the diversity of activities that these molecules display once they are outside. Competing interests The authors declare that they have ... tissue damage and to trigger an immediate response. A key facet of the biology of alarmins is therefore their translocation from the inside to the outside of...

Ngày tải lên: 09/08/2014, 10:23

... (HMFN0839)* 1-Acylglycerol-3-phosphate O-acyltransferase 9 [GenBank:NM_032717.3 ] 34 MTHFD2 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [GenBank:NM_006636.3 ] 35 ... in the same cluster in eight of the eight groups). The selection was then expanded to include genes with 7 of 8, 6 of 8 and 5 of 8 matches to the core re...

Ngày tải lên: 09/08/2014, 20:20

... microinjection of the test agent into NTS. The BRR response was represented by the ratio of the peak magnitude of reflex bradycardia to the peak magni- tude of phenylephrine-induced pressor response. The averaged ... out the neurophysiologic and neuropharmacologic studies, and performed the Western blotting analysis. YJL and ICC participated in the interpretati...

Ngày tải lên: 10/08/2014, 05:21