Báo cáo y học: "Circulating tumour necrosis factor-α bioactivity in rheumatoid arthritis patients treated with infliximab: link to clinical respone" pot

... article Circulating tumour necrosis factor-α bioactivity in rheumatoid arthritis patients treated with infliximab: link to clinical response Hubert Marotte 1 , Wlodzimierz Maslinski 2 and Pierre ... by cytokines in mediating cell–cell interactions in rheumatoid synovium has led to the rational development of treatment with anticytokine agents. Among thes...

Ngày tải lên: 09/08/2014, 06:22

... [1], indi- cating a considerable influence of other pro-inflammatory cytokines beside TNF in perpetuating inflammation in RA. IL-15 has been identified as a pro-inflammatory cytokine of potential ... Daha MR, Kluin PM, Meinders AE, Tak PP: Increased expression of IL- 15 in the synovium of patients with rheumatoid arthritis com- pared with patients with Yersinia-induced ar...

Ngày tải lên: 09/08/2014, 07:20

... play a critical role in initiating and propagating the disease process. The cytokines tumour necrosis factor α (TNFα) and interleukin-1 (IL-1) mediate many of the inflammatory and tissue-damaging activities ... into the peritoneal cavity following TNFα injection intraperitoneally. Similarly, we also ruled out any TNFα-induced enhancement of the level of mRNA for IDO, the enzyme involved...

Ngày tải lên: 09/08/2014, 10:23

... Miller CH, Dutcher PO, Hadley JA, Sanz I: Cutting edge: anti-tumor necrosis factor therapy in rheumatoid arthritis inhibits memory B lymphocytes via effects on lymphoid ger- minal centres and follicular ... blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor. Arthritis Res Ther 2009, 11: R84. 2. Sims G...

Ngày tải lên: 09/08/2014, 14:22

... Introduction Rheumatoid arthritis (RA) is a chronic condition, which leads to varying degrees of functional impairment and disability. In early stages, symptoms reflecting the inflammatory ... destructive mechanisms in arthritis. Semin Arthritis Rheum 2001, 30:7-16. 3. Feldmann M, Maini RN: Discovery of TNF-alpha as a therapeu- tic target in rheumatoid arthritis: preclinical...

Ngày tải lên: 09/08/2014, 01:21

... protein 3; FLICE = Fas-associating protein with death domain [FADD]-like interleukin 1β con- verting enzyme [ICE]; FLIP = FLICE inhibitory protein; HD = high-density; HE = hematoxylin and eosin; ... induced during growth inhibition in murine cell lines [33]. Recently, Taniguchi et al. [34] showed that cyclin-dependent kinase inhibitor p16 INK4a is induced in RA-SF by several growth-inhi...

Ngày tải lên: 09/08/2014, 06:22

... K, Itoh K, Ishiyama S, Saito S, Inoue K, Kamatani N, Gillespie MT, Martin TJ, Suda T: IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. ... synoviocytes in rheumatoid arthritis. Arthritis Rheum 2000, 43:259-269. 37. Shigeyama Y, Pap T, Kunzler P, Simmen BR, Gay RE, Gay S: Expression of osteoclast differentiation fa...

Ngày tải lên: 09/08/2014, 06:22

... function in chronic inflammation, to a ‘network concept’ of interacting activities contributing in synergy across distinct tissue events. In particular, cytokine mediated pathology may be distinct in ... impressive clinical benefits in rheumatoid arthritis (RA), partial and non- responder patients constitute residual unmet clinical need. Establishing the therapeutic pote...

Ngày tải lên: 09/08/2014, 06:22

... phagocytes (trigger the oxidative burst, cytotoxic granule and cytokine release), antigen presen- tation and antibody-dependent cellular cytotoxicity [6]. Con- versely, FcγRIIb contains an inhibitory ... polymorphic variants within FCGR3A or FCGR3B, or in linkage disequilibrium with this haplotype may additionally contribute to disease pathogenesis. Materials and methods Rheumatoid a...

Ngày tải lên: 09/08/2014, 07:20

... of symptoms. Tamai and colleagues [21] recently confirmed its association with disease severity as indicated by inflammatory markers such as C-reactive protein and interleukin-6 levels in early ... resonance imaging examinations of the spine in patients with ankylosing spondylitis, before and after successful therapy with inflix- imab: Evaluation of a new scoring system. Arthriti...

Ngày tải lên: 09/08/2014, 08:23