Báo cáo y học: "Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocyte" pptx

... article Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocyte Aaron R Klooster and Suzanne M Bernier CIHR Group in Skeletal Development and ... induced by epidermal growth factor (EGF)Tumor necrosis factor alpha (TNF-α) enhances elongated cell morphology induced by epidermal...

Ngày tải lên: 09/08/2014, 06:22

... membrane expression by tumor necrosis factor (TNF)α and adalimumab (Ada)Regulation of CD36 membrane expression by tumor necrosis factor (TNF)α and adalimumab (Ada). (a) TNFα reduces the membrane expression ... inflammatory and immune responses modulate the expression of CD36 by macro- phages. IL4 induces the expression of CD36 by activating the regulatory trans...

Ngày tải lên: 09/08/2014, 10:20

... article Tumor necrosis factor alpha- dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro Henning ... pro-inflammatory cytokines in which IL-1 promoted GAG release in lapine and porcine meniscal tissue [19,21]. TNFα, therefore, appears to be another key factor in meniscal diseases....

Ngày tải lên: 09/08/2014, 14:22

... 121 AS = ankylosing spondylitis; SpA = spondyloarthropathies; TNF = tumor necrosis factor. Available online http://arthritis-research.com/contents/7/3/121 Abstract Blocking tumor necrosis factor- α ... rheumatology. Inhibition of tumor necrosis factor- α (TNF-α) proved highly efficacious, with an acceptable safety profile in the chronic treatment of rheumatoid arthritis. Not only di...

Ngày tải lên: 09/08/2014, 06:23

... tumor necrosis factor receptor family member SOBa mRNA; TNFSF, tumor necrosis factor (ligand) superfamily; TRAF, tumor necrosis factor receptor-associated factor; TTRAP, tumor necrosis factor ... lipopolysaccharide-induced tumor necrosis factor- alpha factor; NFKB1, nuclear factor kappa B subunit p105; NFKB2, nuclear factor kappa B subunit p100; RIPK, receptor (...

Ngày tải lên: 09/08/2014, 14:22

... through hypoxia- inducible factor- 1 [4,5]. Recently, visfatin was shown to play a role in e ndothelial angiogenesis by activation of fibroblast growth factor2 , signal transducer and activator * ... antly toxicity effects to the neurologic system as well as to any cultured cells. The visfatin induced by HBO in our study protocol may be caused by oxygen toxicity. In the pres...

Ngày tải lên: 10/08/2014, 05:21

... directly related t o ability t o bind t he IGF1R. Keywords: apoptosis; BIAcore analysis; insulin-like growth factor (IGF); type 1 IGF receptor. Insulin-like growth factors-I and -II ( IGF-I and ... 2002 Characteristics of binding of insulin-like growth factor (IGF)-I and IGF-II analogues to the type 1 IGF receptor determined by BIAcore analysis Correlation of binding af®ni...

Ngày tải lên: 08/03/2014, 22:20

... epidermal growth factor receptor activity. The control exerted by calmodulin on distinct epidermal growth factor receptor-mediated cellular functions is also discussed. Finally, the phosphorylation ... signalling at epidermal growth factor receptors overexpressed in NIH 3T3 cells: phosphoino- sitide hydrolysis, cytosolic Ca 2+ increase and alkalin- ization correlate with...

Ngày tải lên: 06/03/2014, 09:22

... Fraser P: Myc dynamically and preferentially relocates to a transcription factory occupied by Igh. PLoS Biol 2007, 5:e192. 46. Cook PR: A model for all genomes: the role of transcription factories. ... Affymetrix Yeast 2 .0 Genechip ® arrays were first filtered for undetectable signal (< 1; 480 of 5,296 genes excluded) and then sorted in to spliced and u nspliced genes (2,218...

Ngày tải lên: 09/08/2014, 23:20

... Sawada 1 , Yuta Kochi 2 and Kazuhiko Yamamoto 1 1 Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan 2 Laboratory ... and contributes to the exacerbation of TNFα-related inflammatory arthritis and colitis. Introduction Tumor necrosis factor alpha (TNFα) is a potent proinflamma- tory cytokine...

Ngày tải lên: 09/08/2014, 08:23