Báo cáo y học: "Autoantibodies in normals – the value of predicting rheumatoid arthrits" doc

... precise “window of opportunity” for early and Viewpoint Autoantibodies in normals – the value of predicting rheumatoid arthritis Thomas Dörner and Arne Hansen Charite University Medicine Berlin, Free ... early indicators of a definite break in tolerance and may provide insight into the pathogenesis of RA. This raises the possibility to predict RA development in...

Ngày tải lên: 09/08/2014, 06:22

... is a group of inflammatory diseases, with ankylosing spondylitis as the prototype. SpA affects the axial skeleton, entheses, joints and, at times, the eyes. This study tested the hypothesis that ... purposes) Introduction Axial spondyloarthropathy (SpA) is a family of polygenic inflam- matory diseases for which the pathophysiology is complex, with much remaining unknown. Ankylos...

Ngày tải lên: 09/08/2014, 14:22

... the onset of treatment the gene expression profile of patients benefiting from the therapy changed toward the profile of healthy control individuals, whereas the profile of patients who turned ... therapies and their potential side effects, a reliable strategy for identifying nonresponders as soon as possible – ideally even before initiation of therapy – would be...

Ngày tải lên: 09/08/2014, 08:22

... bactericidal/permeability- increasing protein in patients with cystic fibrosis. Q J Med 1996, 89:259-265. 38. Kobayashi O: Clinical role of autoantibody against bacterici- dal/permeability-increasing protein in chronic ... in Otolaryngology: Proceedings of the First International Academic Conference in Immunology and Immunopathology as applied to Otology and Rhinology. Edited by...

Ngày tải lên: 09/08/2014, 01:21

... TNF-activated NFB-DNA binding activity. The regulation of NFB-DNA binding in primary cells can therefore be explained by the non- specific effect of DMSO on NFB activation. In the present study we determined ... cate- gorized by the molecular function of their protein products into categories that included hyaluronic acid binding activity (including Agc1 and Hapln1) and...

Ngày tải lên: 09/08/2014, 01:22

... manually analyzed all these 40 modifications in order to verify the effect of the repeats on the resulting pro- teins. In the majority of cases, the reading frame of the origi- nal protein is ... retention of repeats that can significantly diversify the sequence of the encoded proteins. Fifty percent of variable ITRs modify protein sequences In agreement with...

Ngày tải lên: 09/08/2014, 20:21

... homo- zygosity of deleterious mutations may explain the repeated success of asexuals in nature [32]. Whereas any new insertions in a sexually recombining genome can become homozygous, asexuals carry only ... Coordination infrastructure for the DGC is provided by The Center for Genomics and Bioinformatics at Indiana University, which is supported in part by the METACyt Initia...

Ngày tải lên: 09/08/2014, 20:21

... play an essen- tial role in reducing the severity of the I/R injury by inhibiting neutrophil adhesion in postcapillary venules and by decreasing microvascular constriction [20]. In our study, ... at the 7 and 14 day reperfusion time-points. I/R injury of sciatic nerve has been shown to increase proin- lammatory cytokines which are primarly responsible demyelinization after rep...

Ngày tải lên: 10/08/2014, 09:22

... of the potencial beneficial effects of statins in cardiac surgery interventions. List of abbreviations CABG: Coronary artery bypass graft; CPB: Cardiopulmonary bypass; CPK: Creatine phosphokinase. Authors’ ... reduction of early and late adverse events. The anti-inflammatory action of statins, as we demonstrated [2], its pleiotropic effects and the capacity of reduction o...

Ngày tải lên: 10/08/2014, 09:23