Báo cáo y học: "Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia" pptx

... the amount of synovium infiltrating cells, including plasma cells [39]. Because RF-producing cells are present in inflamed rheumatoid synovium and the local environment may favour synovial RF production ... phenomenon, lasting about 1 year. This might explain why almost all of the infliximab-induced lupus syn- dromes were reported within the first year of treatment in RA. No differences...

Ngày tải lên: 09/08/2014, 01:23

... the cytokine network in such induction has already been demonstrated for another cytokine, interferon γ, inducing the development of autoan- tibodies in patients with hepatitis C viral infection ... anti- inflammatory effects of infliximab have led to their use in other inflammatory diseases such as Crohn's disease [5] and ankylosing spondylitis (AS), with a similar efficacy to t...

Ngày tải lên: 09/08/2014, 01:24

... important in retaining the cells at this site [17,18]. In about 20% of patients with RA, infiltrating T and B lym- phocytes accumulate underneath the synovial lining layer and organize into lymphocyte ... formation is less clear. For instance, ectopic lymphoid tissues were readily observed in mice carrying a transgene for secondary lymphoid tissue chemokine (SLC) [40]. In RA synov...

Ngày tải lên: 09/08/2014, 03:24

... DRB1 In the initial, retrospective study, the frequency of B cells was determined as a percentage of CD19 + lymphocytes from total T lymphocytes and B lymphocytes combined (CD3 + + CD19 + lymphocytes). ... subsequent binding to Fc receptors in rodent erosive polyarthritis models resembling RA [13]. RF production in RA is thought to occur in the synovial infiltrate in affected joints...

Ngày tải lên: 09/08/2014, 03:24

... RA-induced and RA therapy-induced hyperhomocysteinemia to CHF risk in RA has yet to be completely elucidated. Inflammatory cytokines In patients with overt CHF, levels of inflammatory cytokines (TNF-α, ... is tempting to speculate that chronic production of cytokines, including TNF-α, may affect the myocardium in RA in either an endocrine (originating in the synovium) or paracrine...

Ngày tải lên: 09/08/2014, 07:20

... A, et al.: Min- imal clinically important difference in radiological progression of joint damage over 1 year in rheumatoid arthritis: preliminary results of a validation study with clinical experts. ... 3 Probability plot: change/year in total radiographic scoreProbability plot: change/year in total radiographic score. Figure 4 Probability plot: change/year in erosion scoreProba...

Ngày tải lên: 09/08/2014, 08:22

... modifications regulating inflammatory processes The transcription factor NF-κB plays a central role in the induction of genes involved in immunity and inflammation, including cytokines, chemokines, adhesion ... regions. Methyl CpG-binding proteins use transcriptional corepressors for transcriptional silencing or may modify the surrounding chromatin of methylated regions [27]. In oncog...

Ngày tải lên: 09/08/2014, 13:21

... imaging was performed [10]. In our study, CT of the sinuses was performed only to investigate symptoms. Sinus aspergilloma may remain asymptomatic for several years, however, and may therefore be underestimated. Sinus ... found in 3.7% of patients under- going surgery for chronic inflammatory sinusitis [12]. Sinus aspergilloma is often asymptomatic and may therefore be overlooked duri...

Ngày tải lên: 09/08/2014, 14:22

... anti-citrullinated protein antibodies), which can be found already in the preclinical phase of the disease; the presence of lymphocyte aggre- gates containing B cells, which are often surrounded by large numbers ... plasma cells, in the inflamed synovium; and experimental studies showing, for instance, the effects of immune complexes containing rheumatoid factor on tumor necrosis fact...

Ngày tải lên: 09/08/2014, 14:22

... joint synovial hypertrophy and forefoot bursal hypertrophy (Table 7). This suggests that the pattern of presence of MTP joint synovial hypertrophy and forefoot bursal hypertrophy within the forefoot ... Location of forefoot pathology in the RA participants(n (%)) at baseline and twelve months. Legend: SynHy: MTP joint synovial hypertrophy; BurHy: Forefoot bursal hypertrophy. Forefoo...

Ngày tải lên: 10/08/2014, 21:24