Báo cáo y học: "Relaxin''''''''s induction of metalloproteinases is associated with the loss of collagen and glycosaminoglycans in synovial joint" ppsx

... [39]. Conclusions Relaxin causes the targeted induction of collagenase-1 and stromelysin-1 in synovial joint and pubic symphysis fibro- cartilages but not in articular cartilage. This induction of MMPs in joint ... the amount of collagen in fibrocartilaginous tissues from different sites, including the pubic symphysis and synovial joints. These findings als...

Ngày tải lên: 09/08/2014, 06:22

... of the data. RB was responsible for analysis and interpretation of the data. AW performed data analysis. FC and SDavis were responsible for study design and data analysis and interpretation and ... This should be further assessed by a longitudinal study. Introduction Osteoarthritis (OA) is a major cause of morbidity, affecting 60% of men and 70% of women over the...

Ngày tải lên: 09/08/2014, 10:23

... autoimmune exocrinopathy of unknown origin. Therefore the diagnosis of SjS, in the absence of a gold standard, is based on cri- teria containing a number of subjective and objective signs and symptoms. In the ... indicating a disease sensitivity of IgG anti- bodies against α-fodrin of 48%. Nine (43%) of the 21 primary SjS sera were found to contain IgA antibodi...

Ngày tải lên: 09/08/2014, 01:23

... with Ca 2+ calmodulin, they should also inhibit the activity of calcineurin. The four model peptides lesueurin, citropin 1.1, frenatin 3 and caerin 1. 9, all inhibit the activity of calcineu- rin, but at ... the presence of increasing concentrations of Ca 2+ calmodulin, the inhibition dropped by  50% in each case. In addition, these peptides also inhibit the activ...

Ngày tải lên: 31/03/2014, 15:20

... biochemical characteristics, is poorly organized, contains significant amounts of collagen type I, and is susceptible to injury. The breakdown of this inferior repair tissue with time and loading eventually leads ... developing three-dimensional constructs using native and synthetic biomaterials. Clinically significant and satisfactory results from applying autologous ch...

Ngày tải lên: 09/08/2014, 10:21

... autonomous of inflammation [5]. At the dawn of the era of biological therapy in RA, this theory led to the concept of a dual-therapeutic strategy, including anti-inflammatory biological therapy, on ... final common pathway of an array of inflammatory, crystal, and degenerative arthritis. The advan- tage of seeing patients early in the course of disease is tha...

Ngày tải lên: 09/08/2014, 13:22

... participated in the design of the study, analysis of DXA images, performed the statistical analysis and drafts the man- uscript. JL conceived the study and elaboration of the program used to analyse the ... of the various models. R is a programming lan- guage and open source software environment for statistical computing and graphics widely used for data an...

Ngày tải lên: 09/08/2014, 14:22

... properly cited. and plays a key role in OS-induced inflammatory responses by mediating the expression of inflammatory genes in HUVECs [33]. Downregulation of miR-663 in tumor cells may contribute ... arrest and induction of differentiation of HL-60 cells in response to Sch 52900 is due to induc- tion of the cell cycle inhibitor p21WAF, and inhibition of the...

Ngày tải lên: 10/08/2014, 21:23

... electro- phoresis ⁄ MS and immunohistochemistry in combina- tion, the aim of this study was to investigate the genesis- and metastasis -associated proteins, and to Keywords carcinogenesis; colorectal carcinoma; proteomics; ... by extracting Rho family GTPases from membranes and solubilizing them in the cytosol. Moreover, they interact only with prenylated Rho proteins b...

Ngày tải lên: 23/03/2014, 03:20

... have any role in the proteolysis of substrates like SecY or YccA by HflB. We think that the primary role of CIII is associated with k lysogeny. In this respect, the antiproteolytic activity of CIII ... substrates. The relative binding affinity for r 32 –HflB interaction and CIII–HflB interaction would play an important role in the inhibition of proteolysis of r 3...

Ngày tải lên: 23/03/2014, 10:20