Báo cáo y học: "The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin" ppsx

... the numbers of arginine residues in the CDRs of these antibodies can lead to significant alterations in bind- ing to DNA. Arginines in V H CDR3 often play a particularly important role in binding ... CDR3 of UK4V L hinders DNA binding sterically. A similar effect may be occurring with regards to the binding of UK4V L to CL. The effect of point...

Ngày tải lên: 09/08/2014, 06:22

... and endothelial cells into the damaged site. It has been showed that fibroblasts cultured in presence of increasing doses of HA have an increased production of pro-inflammatory cyto- kines such ... proc- ess in a large number of medical disciplines, as evi- dent in ophthalmology, dermatology, dentistry and rheumatology [10,11]. Based up on these data the aim of this st...

Ngày tải lên: 03/11/2012, 11:35

... and MRI findings. Clinical definition of arthritis mutilans Clinical digitised photographs of the hands and feet were obtained in 25 of the 28 patients. These were examined by a rheumatologist ... higher in the AM group than in those with non-AM ero- sive PsA, despite there being no evidence of greater disease activity in terms of clinical scores (skin or joint) or inf...

Ngày tải lên: 09/08/2014, 01:22

... Rheumatology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan 2 Division of Hematology, Department of Internal ... were maintained in a pathogen-free facility at the Hyogo College of Medicine (Nishinomiya, Hyogo, Japan). Animal experiments were performed in accordance with the guideline...

Ngày tải lên: 09/08/2014, 08:22

... with evidence of central nervous system involvement. There are reports indicating a central role for MMPs in increasing permeability of the blood-brain barrier in inflammatory settings [52], which ... activation of the Toll-like receptor 9 signalling pathway [72,73]. Persistently increased glomerular MMP activity could therefore be the result of an inflammatory process tha...

Ngày tải lên: 09/08/2014, 13:22

... here pertain only to baseline findings in these patients, before administration of the study drug or placebo. All patients gave informed consent according to the require- ments of the New Zealand ... and MRI findings. Clinical definition of arthritis mutilans Clinical digitised photographs of the hands and feet were obtained in 25 of the 28 patients. These were exa...

Ngày tải lên: 09/08/2014, 13:22

... nm. Analysis of the Receptor -Binding Data Linear Regression Analysis for Scatchard Plots Thedatawereanalysed[25].Thespecificbindingwas determined by subtracting non-specific binding from the total. The ... of the major pro-apoptotic family members, exerts its effects by compromising the membrane integ- rity leading to leakage of apoptogenic factors such as cytochrome c i...

Ngày tải lên: 10/08/2014, 05:21

... integrity, which together may lead to tissue softening, swelling, thickness changing and roughening of the cartilage surface. During the last decade, researchers have made many efforts to correlate these changes ... and interval in human knee cartilage. We think indirect measurements of the intrinsic physical characteristics of cartilage, as reported in this study, shoul...

Ngày tải lên: 09/08/2014, 01:22

... to the affected joint. Their capacity to suppress both proliferation and cytokine secretion might contribute to a dampening of local inflammatory processes. Keywords: autoimmunity, cytokines, human, ... not only proliferation but also cytokine production, indicating a potential role for regulatory T cells to influence the inflammatory processes in the joint. These feature...

Ngày tải lên: 09/08/2014, 01:23

... widely reported that the early degeneration of articular cartilage involves the loss of proteoglycan and damage of collagen matrix integrity, which together may lead to tissue softening, swelling, ... of the intrinsic physical characteristics of cartilage, as reported in this study, should be interpreted more carefully as they can be affected by many experimental and physi...

Ngày tải lên: 09/08/2014, 13:22