... ideally effective, safe, and well tolerated.NSAIDs have provided the mainstay of pain therapy, particu-larly in the early stages of disease, but are often associated with clinically relevant adverse ... any pharmaceutical company.Authors' contributionsRAM was involved with planning the study, data extraction,analysis, and preparing the manuscript; SD with data extrac-tion, analysis, and ... writing; GTM with planning, data extraction,analysis, and writing the manuscript; HJM with planning, anal-ysis, and writing. All authors read and approved the finalmanuscript.Additional filesReferences1....