Báo cáo y học: "The molecular mechanism of osteoclastogenesis in rheumatoid arthritis" pptx

... of OA patients. Anti- IL-17 antibody significantly inhibited osteoclast formation induced by conditioned media of the cultures of RA syn- ovial tissues in cocultures. Immunostaining of the synovial tissues ... colony-stimulating factor. 281 CFU-M = colony-forming-unit megakaryocyte; COX-2 = cyclooxygenase; ELISA = enzyme-linked immunosorbent assay; GM-CSF = granulocyte–macrophage co...

Ngày tải lên: 09/08/2014, 06:22

... secondary tyrosine kinase domain point mutations that interfere with drug binding is a well-documented phenomenon in CML patients receiv- ing therapy with imatinib [89]. Preclinical studies using AML ... patients by a tyrosine kinase inhibitor. Leukemia 2002, 16:2027-2036. 72. Tse KF, Novelli E, Civin CI, Bohmer FD, Small D: Inhibition of FLT3- mediated transformation by use of a tyrosi...

Ngày tải lên: 10/08/2014, 21:23

... proximal skin involvement, scarring ,or esophageal hypomotility and is more often associated with limited cutaneous involvement [106]. Thus the clinical utility of determining aCL in patients ... with increased severity of scleroderma lung disease. Chest 1998, 114:801-807. 65. Murata I, Takenaka K, Shinohara S: Diversity of myocardial involvement in systemic sclerosis: an 8-year stu...

Ngày tải lên: 09/08/2014, 01:21

... clinical response, suggesting that their RA was not much driven by TNF-α activity alone but probably by other cytokines or mechanisms. The heterogeneity in these patterns may be explained by higher ... functional assay for TNF-α activity was designed using the ability of RA synoviocytes to produce IL-6 and OPG in response to TNF-α [5]. To isolate synoviocytes, RA synovial tissues were f...

Ngày tải lên: 09/08/2014, 06:22

... concept’ of interacting activities contributing in synergy across distinct tissue events. In particular, cytokine mediated pathology may be distinct in cartilage and bone as opposed to synovial tissue ... function in varied tissue cell lineages including keratinocytes, osteoclasts and chondrocytes [2]. Importantly, IL-18 often acts in synergy rather than independently, and for som...

Ngày tải lên: 09/08/2014, 06:22

... may occur as regions of bone oedema which are typically recognized as areas of hyperintense signal on T2w images, also exhibit increased signal after intravenous injection of gadolinium diethylenetriamine ... to synovial membrane to become type B synoviocytes - here they mediate formation of erosions via production of proinflammatory cytokines and matrix metalloproteinases [23,25]....

Ngày tải lên: 09/08/2014, 08:23

... supplementing that normally provided by the chronic inflammatory cells in synovial tissues. This may result in rapid stimulation of bone erosion during disease flares in active RA. Competing interests The ... chronic inflammatory diseases, such as RA, indicates that these cells may play an important role in chronic inflammation. It is increasingly apparent neutrophils exhibit many...

Ngày tải lên: 09/08/2014, 10:20

... balance by existing or currently developed treatments, specific targeting of FcγRs offers a valuable therapeutic window of opportunity. Ways to silence gene expression of activating FcγRs or increase ... A shift in the balance of inhibitory and activating Fcgamma receptors on monocytes toward the inhibitory Fcgamma receptor IIb is associated with prevention of monocyte activation...

Ngày tải lên: 09/08/2014, 10:20

... sources of anti-GAG nAbs. Figure 4 Detection of anti-glycosaminoglycan (GAG) antibody binding to the extracellular matrix of hyaline cartilageDetection of anti-glycosaminoglycan (GAG) antibody binding ... bind to the extracellular matrix of hyaline cartilage. The relatively strong binding of serum antibodies to the extracellular matrix of hya- line cartilage could be increasingl...

Ngày tải lên: 09/08/2014, 13:22

... management including diagnosis, family studies, prognostic information, prenatal diagnosis and is useful in defining new diseases. In this review we outline the clinical utility of molecular testing ... the majority of X chromosomes bearing the wild type allele are inactivated purely by chance. Females may manifest X-linked disorders in this situation. More rarely, skewed lyonisa...

Ngày tải lên: 08/08/2014, 21:20