Báo cáo y học: "Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation" potx
Báo cáo y học: "Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation" potx
... that these molecules are involved in synovial activation in RA. Most importantly, the data indicate that the expression of certain genes in RA-SF depends on the stage of proliferation; therefore, ... growth-inhibited conditions,including irradiation, serum depletion and high cellulardensity. Surprisingly, they showed also that the genetransfer of p16 inhibits proliferation of synovial fibroblasts in ... mecha-nisms most likely play a critical role in maintaining the long-term activation of RA-SF and thereby contribute tomatrix degradation. In addition to the expression of these anti-apoptotic...
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Báo cáo y học: "Circulating tumour necrosis factor-α bioactivity in rheumatoid arthritis patients treated with infliximab: link to clinical respone" pot
... strong inhibition of circulating TNF-α-related activity during the first infusion. The link between strong anti-TNF-α activity induced by the first infusion and the good clinical response confirms ... of a bioassay when function is the key. Suchcomplexity has been observed when trying to explain loss of infliximab response by the induction of anti-mouseantibodies [11]. Once again, only the ... demonstration of inhibitory activity in vivo would allow such a conclusion tobe drawn.Conclusion In conclusion, this bioassay was able to predict correctly the clinical response in 69% of cases...
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Báo cáo y học: "Interleukin-18: a therapeutic target in rheumatoid arthritis" potx
... models of cytokine effector function in chronicinflammation, to a ‘network concept’ of interactingactivities contributing in synergy across distinct tissueevents. In particular, cytokine mediated ... of CommentaryInterleukin-18: a therapeutic target in rheumatoid arthritis? Iain B McInnes, Foo Y Liew and J Alastair GracieDivision of Immunology, Infection and Inflammation, University of Glasgow, ... although lower affinity binding of the latter suggests it is a minor contributor.We first reported IL-18 expression in RA synovial membrane in macrophages, together with lining layer fibroblasts. ...
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Báo cáo y học: " What is MRI bone oedema in rheumatoid arthritis and why does it matte" ppt
... immunohistochemicalstudy of RA subchondral bone (from specimens obtained at the time of joint replacement), using contemporarytechniques. They found lymphoid aggregates on the sub-chondral side of the joint in ... marrow…raising the hypothesis that subchondral bone marrowinflammation might develop independent of the propagation of synovial tissue.” The MRI finding of bone oedema has been an importantdriver in ... travel via the circulation to synovial membrane to become type B synoviocytes - here they mediate formation of erosions via production of proinflammatory cytokines andmatrix metalloproteinases [23,25]....
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Báo cáo y học: "Inflammatory cells and bone loss in rheumatoid arthritis" doc
... increase in RANKL levels in the joint, supplementing that normally provided by the chronic inflammatory cells in synovial tissues. This mayresult in rapid stimulation of bone erosion during diseaseflares ... indicates that they can play similar roles in chronicinflammation. Many of these factors are pivotal in causingtissue destruction, either directly or indirectly.We are still to determine the ... exhibit many of the properties of their fellow phagocytic cells of the monocyte/macrophage lineage. Their rapid secretion of many factorsthat are also released by macrophages, lymphocytes andfibroblasts...
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Báo cáo y học: "γ Activating and inhibitory Fcγ receptors in rheumatoid arthritis: from treatment to targeted therapies" potx
... balance of inhibitory andactivating Fcgamma receptors on monocytes toward the inhibitory Fcgamma receptor IIb is associated with prevention of monocyte activation in rheumatoid arthritis. Arthritis ... treatment of arthritis. Considering the arthritis- inducing capacity of antibodies characteristic for RA[5], the new opportunity to study surface expression of inhibitory and activating FcγRs ... express FcγRIIb in addition to activating FcγRs [1,8]. Considering the pivotal roleplayed by these macrophages and dendritic cells in RA, and the influence of FcγR balance on these cells in RA, it...
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Báo cáo y học: "Natural autoantibodies reactive with glycosaminoglycans in rheumatoid arthritis" ppsx
... relatively strongbinding of serum antibodies to the extracellular matrix of hya-line cartilage could be increasingly inhibited by pre-incubation of the serum with increasing amounts of CSC (Figure ... have not yet been systematically investigated in RA, in spite of the fact that hyaline cartilage and synovial fluid containlarge amounts of GAGs including HA, CS and KS. These car-bohydrates ... interactionsmight play a pivotal role in the recognition of polyanionicGAGs by these immunoglobulins. In line with the polyreactivenature of nAbs, we found a strong statistical correlation amongIgM-type GAG-specific...
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Báo cáo y học: "Molecular profile and copy number analysis of sporadic colorectal cancer in Taiwan" potx
... resolution. Molecular karyotype profiling of the two subtypes of sporadic CRCs revealed significantdifferences in the extent and distr ibution of CN altera-tions in the cancer genome. Combining the ... analyzed includedlymphovascular invasion, invasive tumor pattern, grade of differentiation, mucin production and intratumorallymphocyte infiltration. These pathological features weredefined by ... results.Additional materialAdditional file 1: The size distribution of copy number variation in colorectal cancer. CNVs were called by using Affymetrix GenotypingConsole program based on the intensity...
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Báo cáo y học: "Pre-hospital intubation by anaesthesiologists in patients with severe trauma: an audit of a Norwegian helicopter emergency medical service"
... during the study period and adhered togenerally accepted indications for ETI outside the hospi-tal [1,2,10,11]. Only minor adjustments were made tothese guidelines during the study period. There ... of airway device and drugs used tofacilitate ETI, complications and the use of monitoring,including capnography. We anonymised the involvedHEMS physicians and recorded them as “anaesthesiologistspecialist” ... airway algorithm in the service in the period other than the one available in the anaesthesiol-ogy department under which it is organised. McCoy lar-yngoscope [2] and trans-tracheal kits were the...
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Báo cáo Y học: Cytochrome c from a thermophilic bacterium has provided insights into the mechanisms of protein maturation, folding, and stability potx
... of HT c-552 may depend on a few strong noncovalentinteractions. We further found that the increase in the stability of the quintuple mutant is almost the same as the sum of the three individual ... If the interactions are spatially separated, their contributions maybe additive, in which case we can clearly identify protein-stabilizing factors. The combination of precise comparison of the ... respectively. (A) The region around A7/M13 in HT c-552 and the corresponding regions. (B) The region around Y3 4 /Y4 3 in HT c-552 and the corresponding regions. (C) The region around I78 and the heme...
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