Báo cáo y học: "Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation" potx

... that these molecules are involved in synovial activation in RA. Most importantly, the data indicate that the expression of certain genes in RA-SF depends on the stage of proliferation; therefore, ... growth-inhibited conditions, including irradiation, serum depletion and high cellular density. Surprisingly, they showed also that the gene transfer of p16 inhibits pr...

Ngày tải lên: 09/08/2014, 06:22

... strong inhibition of circulating TNF-α-related activity during the first infusion. The link between strong anti-TNF-α activity induced by the first infusion and the good clinical response confirms ... of a bioassay when function is the key. Such complexity has been observed when trying to explain loss of infliximab response by the induction of anti-mouse antibodies [11]. O...

Ngày tải lên: 09/08/2014, 06:22

... models of cytokine effector function in chronic inflammation, to a ‘network concept’ of interacting activities contributing in synergy across distinct tissue events. In particular, cytokine mediated ... of Commentary Interleukin-18: a therapeutic target in rheumatoid arthritis? Iain B McInnes, Foo Y Liew and J Alastair Gracie Division of Immunology, Infection and Inflamm...

Ngày tải lên: 09/08/2014, 06:22

... immunohistochemical study of RA subchondral bone (from specimens obtained at the time of joint replacement), using contemporary techniques. They found lymphoid aggregates on the sub- chondral side of the joint in ... marrow… raising the hypothesis that subchondral bone marrow inflammation might develop independent of the propagation of synovial tissue.” The MRI fin...

Ngày tải lên: 09/08/2014, 08:23

... increase in RANKL levels in the joint, supplementing that normally provided by the chronic inflammatory cells in synovial tissues. This may result in rapid stimulation of bone erosion during disease flares ... indicates that they can play similar roles in chronic inflammation. Many of these factors are pivotal in causing tissue destruction, either directly or indirectly....

Ngày tải lên: 09/08/2014, 10:20

... balance of inhibitory and activating Fcgamma receptors on monocytes toward the inhibitory Fcgamma receptor IIb is associated with prevention of monocyte activation in rheumatoid arthritis. Arthritis ... treatment of arthritis. Considering the arthritis- inducing capacity of antibodies characteristic for RA [5], the new opportunity to study surface expression of inhi...

Ngày tải lên: 09/08/2014, 10:20

... relatively strong binding of serum antibodies to the extracellular matrix of hya- line cartilage could be increasingly inhibited by pre-incubation of the serum with increasing amounts of CSC (Figure ... have not yet been systematically investigated in RA, in spite of the fact that hyaline cartilage and synovial fluid contain large amounts of GAGs including HA, CS and K...

Ngày tải lên: 09/08/2014, 13:22

... resolution. Molecular karyotype profiling of the two subtypes of sporadic CRCs revealed significant differences in the extent and distr ibution of CN altera- tions in the cancer genome. Combining the ... analyzed included lymphovascular invasion, invasive tumor pattern, grade of differentiation, mucin production and intratumoral lymphocyte infiltration. These pathological...

Ngày tải lên: 10/08/2014, 05:21

... during the study period and adhered to generally accepted indications for ETI outside the hospi- tal [1,2,10,11]. Only minor adjustments were made to these guidelines during the study period. There ... of airway device and drugs used to facilitate ETI, complications and the use of monitoring, including capnography. We anonymised the involved HEMS physicians and recorded them as...

Ngày tải lên: 25/10/2012, 09:56

... of HT c-552 may depend on a few strong noncovalent interactions. We further found that the increase in the stability of the quintuple mutant is almost the same as the sum of the three individual ... If the interactions are spatially separated, their contributions may be additive, in which case we can clearly identify protein- stabilizing factors. The combination o...

Ngày tải lên: 24/03/2014, 03:21