Báo cáo khoa học: "The "Win-Win" initiative: a global, scientifically based approach to resource sparing treatment for systemic breast cancer therapy" pdf

... initiative to expand availability of resource sparing Breast Cancer Systemic Therapy (BCST) and hope that such strategy may meet the demand for effective, affordable breast cancer care for patients ... col- laboration and coordinating efforts and ideas. • Formation of a collaborative task force group that aims at more availability and affordability of systemic cancer...

Ngày tải lên: 09/08/2014, 04:21

... Gln15 and the carbonyl oxygen atoms of Asp11 and Asn23 (Fig. 3) in an arrangement similar to what is observed in VPRK. Both PRK and VPRK have calcium bound at Ca3. SPRK also has an aspar- tic acid ... two SO 4 2– ions and one Ca 2+ ion. The average B-factor is 8.86 A ˚ 2 for all enzyme atoms and 10.05 A ˚ 2 for all atoms. The electron density is well defined for the whole molecule...

Ngày tải lên: 19/02/2014, 07:20

... this alignment that all PAS-annotated A. thaliana proteins also contain a PAC motif, and conversely that all PAC- annotated A. thaliana proteins contain a PAS domain. Therefore, in the case of A. ... new mechanism for heme-driven signal transduction, Proc. Natl Acad. Sci. USA 95, 15177–15182. 22. Miyatake, H., Kanai, M., Adachi, S.I., Nakamura, H., Tamura, K.,Tanida,H.,Tsuchiya,T.,Ii...

Ngày tải lên: 19/02/2014, 12:20

... no r eason to assume the existence of any internal return, and the respective value of a wasassumedtobeequaltozero(Table2). According to X-ray data [15,16] the abstraction of the a- proton is ... the action of aminoferase. Biokhimia 12, 556–568 (in Russian). 2. Esaki, N., Nakayuma, T., Sawada, S., Tanaka, H. & Soda, K. (1985) Proton NMR studies of substrate hydrogen exchange reacti...

Ngày tải lên: 19/02/2014, 16:20

... tutoring task. In addition, the SIH is not always available and users have to activate it manually. Other visual improvements for dialogue -based computer tutors have been explored in the past (e.g. ... Tuto r 5 362 that naïve users can reliably annotate the informa- tion needed for the NM (Passonneau and Litman, 1993). Our NM design choices should also have an equivalent in a...

Ngày tải lên: 20/02/2014, 12:20

... benyamin@univ-montp2.fr Abbreviations: ask, skeletal muscle a- actinin; asm, smooth muscle a- actinin;Calp1,calpain1(l-calpain); Calp2, calpain 2 (m-calpain); CaM, calmodulin; ELISA, enzyme-linked immunosorbant assay; FITC, ... shows that the C-terminal domain of a- actinin and each calpain subunit, 28 and 80 kDa, participates in the interaction. In particular, the autolysed calpain form (...

Ngày tải lên: 07/03/2014, 21:20

... NRG-5¢ _for NRG-Beta_rev TCTCCGGCGAGATGTCCGA GGCAGCGATCACCAGTAAAC 677 GAPDH GAPDH _for GAPDH_rev GAAGGGCTCATGACCACAGTCCAT TCATTGTCGTACCAGGAAATGAGCTT 450 Fig. 2. Proteolytical processing of APP and NRG-1 in U373 ... NRG-jD _for NRG-TM_rev TGAAAGACCTTTCAAACCCCTC GTTTTGCAGTAGGCCACCAC Approximately 200 (depending on isoform) Immunoglobulin domain (type I and II) NRG-IG _for NRG-TM_rev GCCAGGG...

Ngày tải lên: 16/03/2014, 04:20

... protein for cPLA 2 -a at its site of localization. Several studies have also implied that cPLA 2 -a may be regulated by cytoskeletal interactions. Cytochalasin B, an inhibitor of actin polymerization, ... the regulation of cPLA 2 -a activity and localization. Ann- exin V, for example, has been shown to exhibit sim- ilar membrane relocation kinetics to cPLA 2 -a [35] and severa...

Ngày tải lên: 16/03/2014, 18:20

... NN, SP, and OM to true and XX to false. All four annotators agreed upon a true label for 46 instances and a false label for 30 instances, with an average pairwise Kappa (computed via NTLK) ... repeatable results. However, it was too abstract to consistently apply to large quantities of candidate phrases in sentences, a necessity for corpus creation. A brief attem...

Ngày tải lên: 16/03/2014, 19:20

... Aoyama, A. (1991) aB-Crystallin is a small heat shock protein. Proc. Natl Acad. Sci. USA 88, 3652–3656. 33. Boonstra,J.,Schamhart,D.H.,deLaat,S.W.&vanWijk,R. (1984) Analysis of K + and Na + transport ... content than a- crystallin and therefore a greater ability to bind fructose. The resealed BSA did not display any protective activity and the 86 Rb uptake was similar to that w...

Ngày tải lên: 17/03/2014, 03:20