... Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, MD, USA3 Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute at ... Bagossi1, Terry D. Copeland3,Alexander Wlodawer2 and David S. Waugh21 Department of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Hungary2 ... toaccommodate the OH group of Tyr, while simulta-neously creating an opportunity for a hydrogen bondto form between the OH of P2 Tyr in the substrate and that of Ser209 in the enzyme. In practice,...