Báo cáo khoa học: "Outcomes of resection and non-resection strategies in management of patients with advanced colorectal cancer" doc

... MEME block 1 and their conservation in the years studied, in addition to its overlap with a single receptor binding site infers block 1 importance in selective and specific receptor binding and host ... nature of this site. The HA protein is on the surface of the influenza particle and is involved in receptor attachment and binding and antigenic determinants. This st...

Ngày tải lên: 20/06/2014, 01:20

... survival of patients treated with resection and non -resection Author Resection Non -resection p value Number of patients Median survival (months) Number of patients Median survival (months) *Scoggins ... com- pared with other interventional, non -resection, treatment modalities. Non -resection strategies should be offered as part of the process of informed co...

Ngày tải lên: 09/08/2014, 04:21

... domain inter- acts with an inhibitory phosphotyrosine in the C-terminus. Activation involves dephosphorylation of this inhibitory phosphotyrosine, followed by intermolecular autophosphorylation of ... catalyti- cally inactive. In this autoinhibited conformation, the SH2 domain binds to pY i on the C-terminal tail, and the Src homology 3 (SH3) domain binds to the linker between the...

Ngày tải lên: 18/02/2014, 11:20

... loop is involved in binding one of the (co)substrates of CoaB, indicating that the provided models of the substrate binding sites of human CoaB do not give a complete insight into the active-site architecture ... conserved in CoaB proteins. Residues of the N-terminal part of the Escherichia coli CoaB domain that are conserved in CoaB (Dfp) proteins from all kingdoms of lif...

Ngày tải lên: 19/02/2014, 12:20

... 1) and the N1 of the adenine ring [4]. Besides d-myo-inositol 1,4,5-trisphosphate (InsP 3 ) and nicotinic acid adenine dinucleotide phosphate (NAADP; reviewed in [4a]), cADPR is one of the prin- cipal ... cyclized between N1 of inosine and C2 of the northern ribose [60]. In addi- tion, 8-Br-N1-cIDPR induced Ca 2+ signalling in intact T-cells [61,62]. This finding was surpri...

Ngày tải lên: 20/02/2014, 01:20

... tube containing 5 lL of FITC Annexin V and 5 lL propidium iodide. The cells were gently mixed and incubated for 15 min at room temperature (25 °C) in the dark. Finally, 400 lLof1· binding buffer ... the safety of MB, the absence of undesirable effects on the central nervous system, and the lack of induction of in ammatory responses [22]. Despite a long-standing interest in...

Ngày tải lên: 05/03/2014, 23:20

... nature of the involvement of GAPDH and the CAG expansion of the mutant huntingtin protein. One such scenario is that the interaction between poly- glutamine-containing proteins and GAPDH results in a ... amino acids of human huntingtin with 82 polyglutamine repeats exclusively in brain, with the level of the trans- gene product remaining lower than the level of the end...

Ngày tải lên: 23/03/2014, 10:20

... study of amino acid biosynthesis and central carbon metabolism of the yeast P. pastoris. In the framework of this study, we have established the BDF 13 C-labeling approach of proteinogenic amino ... State University of New York, the Spanish Ministry of Science and Technology (CICYT project PPQ2001-1908), and the Academy of Finland (projects 52311 and 202409). The autho...

Ngày tải lên: 23/03/2014, 12:20

... transporters and are involved in Na + binding [19]. Also present are conserved residues D32 in the first TMD and S321 and S324 in TMD7, thought to be involved in catecholamine binding [20]. There ... octopamine and tyramine are more potent blockers of [ 3 H]dopamine (DA) uptake by TrnOAT than by TrnDAT. D -Amphetamine is a strong inhibitor and L -nor- epinephrine a weak inh...

Ngày tải lên: 23/03/2014, 20:22

... Grazing animals in the community forest - Prevention of forest fire - Checking and preventing outsiders from shifting cultivation, illegal logging or hunting, and illegal buying, selling and ... rates of 63-68% [1]. Forested land comprises 84% and 90% respectively of the total land area and is of paramount importance for community livelihoods, including collection of...

Ngày tải lên: 21/06/2014, 04:20