... in terms of transformation capacity, membrane localization and phosphorylation of key residues?Comparison between the activation of ITK–SYK and BTK–SYKTo determine its activation capacity, ... ª 2011 FEBSMINIREVIEWTEC family kinases in health and disease – loss -of- function of BTK and ITK and the gain -of- function fusions ITK–SYK and BTK–SYKAlamdar Hussain1,2,*, Liang Yu1,3,*, ... missing data.The phenotype of XLA and thepotential of BTK and ITK inhibitorsThe outcome of defective BTK signaling in humanshas been described previously in detail [26,27], and therefore we will...