Báo cáo y học: "Successful immunotherapy with matrix metalloproteinasederived peptides in adjuvant arthritis depends on the timing of peptide administration" pdf

... Veenendaal, The Netherlands). The relative MHC binding affinity (IC 50 value) is expressed as the con- centration range of competitor peptide (µM) resulting in 50% inhibition of the MHC binding of the ... usefulness of MMP peptides for immunotherapy. However, a clear understanding of proper timing of peptide administration is crucial for the development of...

Ngày tải lên: 09/08/2014, 03:24

... even if they heavily condition the everyday life of patients and often require interventions [11,12]. Given this background, and the consequent uncertainty in the correct classification of symptomatology ... dimension. 'Interpersonal Sensitivity' focuses on feelings of personal inadequacy and inferiority, partic- ularly by comparison with other individuals. Self-de...

Ngày tải lên: 08/08/2014, 23:21

... delaying DMARD therapy by only a few months decreased the ability of the monotherapy to induce remis- sion [20]. The benefits of combination therapy were unaf- fected by delay. Not all trials of ... remission with combination therapy but only 11 of 98 patients achieved remission with monotherapy. Remission remained more frequent with combination therapy at 2 years. Subsequ...

Ngày tải lên: 09/08/2014, 01:23

... mecha- nisms most likely play a critical role in maintaining the long-term activation of RA-SF and thereby contribute to matrix degradation. In addition to the expression of these anti-apoptotic ... that these molecules are involved in synovial activation in RA. Most importantly, the data indicate that the expression of certain genes in RA-SF depends on the sta...

Ngày tải lên: 09/08/2014, 06:22

... placed on the restricted diet, we con- firmed by careful history and inspection of food trays that they had consumed only the minimal amounts of NOx allowed by the diet. Although control subjects on ... excreted in the urine constitutes 50 to 60% of the total body clearance of these compounds, with the remaining amounts being eliminated in unknown proportions by...

Ngày tải lên: 09/08/2014, 08:22

... expressed the transduced cytokine only in bone-marrow-derived cells, not in fibroblasts or chondrocytes of the joints. There would there- fore be no initiation of inflammation in the joints without the infiltration ... LPS stimulation or TNBS administration. These results strongly suggest that IL-32 functions in cooperation with other inflam- matory signals in vivo. Th...

Ngày tải lên: 09/08/2014, 08:23

... Takahara H, Sugawara K, Ikenaka T: Conver- sion of peanut trypsin-chymotrypsin inhibitor B-III to a chymo- trypsin inhibitor by deimination of the P1 arginine residues in two reactive sites. J Biochem ... protein. ELISA analysis of the fractions containing IgG ICs showed two peaks in the elution profile of both RA samples, but not in the corresponding fractions from the...

Ngày tải lên: 09/08/2014, 10:23

... of the erythrocyte sedimentation rate on the disease activity score, the use of this score represents a handicap for the evaluation of the efficacy of cyclosporin A on disease activ- ity. On the ... efficient treatment of RA in Spain. Throughout the follow-up of the EMECAR cohort, the percentage of patients without any DMARD declined while the frequen...

Ngày tải lên: 09/08/2014, 13:22

... further functional investigation of their active involvement in chronic inflammatory arthritis. Introduction There is increasing evidence for the presence of neuronal growth factors in chronic inflammatory ... citation purposes) Using immunohistochemistry, we previously performed a detailed analysis on the synovial expression of neurotrophins showing convincingly high levels...

Ngày tải lên: 09/08/2014, 14:21

... identify key cytokines specifically involved in the pathogenesis of SSc-related lung disease. Furthermore, in a cross-sectional study, the correlation of cytokine and chemokine levels with signs of ... allowing the detection of cytokines without any BALF manipulation that could influence the stability of cytokines. By using this technique, we observed abnormalities in...

Ngày tải lên: 09/08/2014, 14:22