... sites, including the pubic symphysis and synovial joints. These findings alsosuggest that in fibrocartilaginous tissues, including the TMJdisc and possibly the pubic symphysis, relaxin decreasescollagen ... tem-poromandibular joint (TMJ) disc, and the pubic symphysis.Within the pubic symphysis of several species, the repro-ductive hormone relaxin induces matrix remodeling activityduring pregnancy and parturition, ... degeneration in inflammatory joint diseases, including rheumatoid arthritis and osteoarthritis [33-35]. Our findings show that relaxindirectly modulates MMP expression and probably causesmatrix loss in...