Báo cáo y học: "Molecular action of methotrexate in inflamma

Báo cáo y học: "Molecular action of methotrexate in inflammatory diseases" ppt

... which methotrexate may diminish inflammation in the joint is by diminishing cytokine production. Numerous studies have demonstrated dimin- ished levels of inflammatory cytokines in the serum of patients. ... much of the toxicity of methotrexate without interfering with the anti -inflammatory efficacy of the drug, whereas very high doses of folinic acid also prevent met...

Ngày tải lên : 09/08/2014, 03:24

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Báo cáo y học: "The role of Probiotics in allergic diseases" pptx

... role of the intestinal microflora for the development of the immune system in early childhood. Eur J Nutr 2002, 41(Suppi 1):I32-7. 18. Penders J, et al.: Molecular finger printing of the intestinal microbiota ... allergy. factors influencing development of the microbiota. Ann Med 1999, 31(4):288-92. 15. Kalliomaki M, Isolauri E: Role of intestinal flora in the development of...

Ngày tải lên : 08/08/2014, 21:20

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Báo cáo y học: "Molecular Virology of Hepatitis C Virus (HCV): 2006 Update"

... integral component of the enzyme core [41]. Surprisingly, the NS3 serine protease recently turned out to influence the innate cellular host defense by inhibition of RIG-I and TLR3 signalling ... proteolysis experiments recently allowed the definition of three protein domains within the cytosolic domain [59]. More recently, the three-dimensional structure of the N-terminal domain...

Ngày tải lên : 02/11/2012, 10:00

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Tài liệu Báo cáo Y học: Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain docx

... functions of heparin binding and substrate recognition were mutagenized. Arg405 plays an important role in heparin binding in the active dimer. Lys413/Lys414 or Lys414 regulates heparin aﬃnity in both monomeric ... of the carboxyl-terminal domain Yoko Kobayashi, Toshiaki Nakajima and Ituro Inoue Division of Genetic Diagnosis, Institute of Medical Science, The University of Tok...

Ngày tải lên : 21/02/2014, 15:20

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Báo cáo Y học: Molecular interaction of neutral trehalase with other enzymes of trehalose metabolism in the ﬁssion yeast Schizosaccharomyces pombe pdf

... METHODS Strains and culture media The S. pombe strains employed in this study are listed in Table 1. They were routinely grown with shaking at 28 °C in YES [19] or EMM2 with or without thiamin (5 mgÆL )1 ) [12]. ... argue against the participation of a unique set of interactions involving association of Ntp1p molecules and could be taken to indicate a speciﬁc event occurring durin...

Ngày tải lên : 08/03/2014, 23:20

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Báo cáo Y học: Molecular cloning of columbamine O-methyltransferase from cultured Coptis japonica cells pot

... S-adenosyl- L -methionine: coclaurine N-methyltransferase; 4¢OMT, S-adenosyl- L -methionine:3¢- hydroxy-N-methylcoclaurine 4¢-O-methyltransferase; SMT, S-adenosyl- L -methionine:scoulerine 9-O-methyltransferase; ... 2,3,9,10-tetrahydroxyprotoberberine and tetrahydrocolumbamine. Products with a m/z increase of 14 mass units were observed only in the CoOMT reaction. Tetrahydrocolumbamine wa...

Ngày tải lên : 17/03/2014, 10:20

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Báo cáo Y học: Coordinated action of protein tyrosine phosphatases in insulin signal transduction potx

... homogeneous preparations of PTP-1B protein into Xenopus oo cytes decreases t yrosine phosphorylation of proteins correspond- ing to the molecular m ass of the IR. Correspondingly, insulin-induced S6 kinase activity ... regulatory s ubunit of phosphatidylinositol 3-kinase (PI3-kinase). Binding to p85 recruits the p110 catalytic subunit of PI3-kinase, resulting in the activation of...

Ngày tải lên : 17/03/2014, 23:20

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Báo cáo Y học: Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery ﬁbroblasts A role for phosphoinositide 3-kinase pot

... Veterinary Pathology, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Edinburgh, UK; 4 Respiratory Medicine Unit, Department of Medicine, University of Cambridge School of Clinical ... being inhibited completely by PD98059 [31]. Moreover, in pulmonary artery ﬁbroblasts, inhibition of PtdIns 3-kinase by wortmannin or LY294002 inhibited completely duodenase-induced [...

Ngày tải lên : 24/03/2014, 03:21

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Báo cáo Y học: Molecular characterization of MRG19 of Saccharomyces cerevisiae Implication in the regulation of galactose and nonfermentable carbon source utilization pdf

... Voronkova, V., Raney, A. & Young, E.T. (1999) Functional analysis of the yeast Glc7-binding protein Reg1 identiﬁes a protein phosphatase type 1-binding motif as essential for repression of ADH2 expression. ... active in the presence of a nonferment- Fig. 3. Galactokinase activity in gal80MRG19 and gal80mrg19 strains. Cells were grown to D 600 of 0.5 in synthetic complete med...

Ngày tải lên : 31/03/2014, 08:20

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Báo cáo y học: "Selective amplification of glucocorticoid anti-inflammatory activity through synergistic multi-target action of a combination drug" ppsx

... model. Figure 1 Synergistic anti -inflammatory activity of prednisolone and dipyridamole in vitroSynergistic anti -inflammatory activity of prednisolone and dipyridamole in vitro. (a) Dipyridamole and ... effects including suppression of HPA axis, osteoporosis, and skin atrophy are probably induced, at least in part, by DNA-binding-independent repressive effects [8]. Similarly,...

Ngày tải lên : 09/08/2014, 01:22

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