Báo cáo y học: "Use of soluble MHC class II/peptide multimers to detect antigen-specific T cells in human disease " pps

... capable of detecting the great majority of the T cells that can respond to peptide in vitro. A final limitation of this technology is probably the techni- cal difficulty in generating particular MHC ... measure of the affinity of the TCR for the MHC/ peptide. Binding of the multimer was shown to be mostly indepen- dent of CD4 [6]. MHC class II/peptide multi...

Ngày tải lên: 09/08/2014, 03:24

... maintained. Forty- eight hours later, the patient was again returned to the operating room for re-exploration. At laparotomy, the packs were noted to be within a hemostatic field. Although directly ... for the arrest of hemorrhage. The goal of the study was to assess the hemostatic and adhesive properties of Stasilon® in the setting of life- threatening refractory hemorrhage....

Ngày tải lên: 11/08/2014, 14:21

... and Methods Weight Loss Protocol Our study consisted of fifty three participants, eighty percent of which were women, with ages ranging from 26 to 63. The starting body mass index of these ... dieting. The data indicated that the treatments not only reduced body fat mass and total mass but also improved the lipid profile. The changes in body composition correlated with the l...

Ngày tải lên: 25/10/2012, 10:51

... these individuals, western medicine community pharmacists might be the only point of contact when they had minor aliments. Therefore, there is a need in promoting and extending the roles of the ... medication was obtained from western medicine community pharmacists, we contend that the role of community pharmacists in pri- mary care must not be underestimated. This is vividly illust...

Ngày tải lên: 25/10/2012, 10:06

... following chiropractic care on patients attending the RMIT University chiropractic teaching clinics. The second objective was to investigate the validity of the MyMOP2 instrument to detect a change in ... delivered by student chiropractors in a clinical teaching facility. The W-BQ12 was also used as a tool to assess the validity of the well being component of the MyMOP2 agai...

Ngày tải lên: 25/10/2012, 10:06

... lacking the drug. Further, the residual activity detectable in doxycyclin-treated TRE2/3R cells was only threefold to fivefold higher than that in parental TRE2/3 cells, indicating that the TRE-CMV ... transcriptional activity of the TRE-CMV promoter was enhanced several-fold by both types of inhibitors. Apparently an opening of the chromatin structure through hyperacetylation...

Ngày tải lên: 22/02/2014, 07:20

... cAMP-dependent protein kinase on Ser40 in the regulatory domain [9] may support an ubiquitination of the e nzyme by the cytosolic Ub-conjugating enzyme system after its membrane insertion. In contrast to ... vidence in s upport of d egradation of hTH1 by the Ub-proteasome pathway was obtained in stability studies of recombinant hTH1 in the in vitro reticulolysate system...

Ngày tải lên: 17/03/2014, 17:20

... antigen-specific T cells independently of their cytokine secretion profile, the possibility of sorting unstimulated T cells and of having a tool for the antigen-specific detection of T cells in experi- ments ... streptavidin that specifically bind with high avidity to T cell receptors. In comparison with intracellular cytokine staining, the major advantage of...

Ngày tải lên: 09/08/2014, 01:24

... access to cell membrane-bound receptor, the binding of which leads to the activation of inflammatory pathways. Consistent with this concept, RA patients treated with meth- otrexate, one of the most ... with RA might increase the propensity towards inflammation, whereas treatment with methotrexate counteracts this feature. Competing interests The author(s) declare that they have no c...

Ngày tải lên: 09/08/2014, 06:23

... distribution. BMI, body mass index; CRP, C-reactive protein; DAS28, disease activity score using 28 joint counts; DMARD, disease- modifying antirheumatic drug; ESR, erythrocyte sedimentation rate; ... only, hydroxychloroquine only, tumour necrosis factor-blocking agents, combination of disease- modifying antirheumatic drugs, pack-years, smoking, erosions, DAS28 (disease activity score...

Ngày tải lên: 09/08/2014, 14:22