Báo cáo y học: "The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases" pot

... syndrome and alter the course of established disease. These data suggest that autologous T cells primed and expanded with TGF-β have the potential to be used as a therapy for patients with systemic ... systemic lupus erythematosus and other chronic inflammatory diseases. This novel adoptive immunotherapy also has the potential to prevent the rejection of alloge...

Ngày tải lên: 09/08/2014, 03:24

... manifestations. The association of CD4 + CD28 – T cells with disease status has given rise to the hypothesis that these cells directly contribute to disease manifestations. Patients with nodulosis and extra-articular ... functionally active and have the ability to release cytokines in the absence of a costimulatory pathway. CD4 + CD28 – T cells contribute to the cell infil...

Ngày tải lên: 09/08/2014, 01:22

... participated in study design, and coordinated acquisition of clinical data and laboratory samples, as well as entry of clin- ical and laboratory variables into the database. All authors par- ticipated ... statistical analyses. TM and JOC coordinated the acquisition of laboratory samples, clinical data acquisition, and entry of clinical and laboratory variables into the...

Ngày tải lên: 09/08/2014, 13:21

... induction of a population of Treg and documentation of their in vivo potential was an important next step. In pursuit of this goal, recent studies demonstrated for the first time that the transfer ... Infection and Immunity Branch, National Institute of Dental and Craniofacial Disease, National Institutes of Health, Bethesda, Maryland, USA 2 Mucosal Immunology Unit,...

Ngày tải lên: 09/08/2014, 06:22

... was ampli®ed by PCR from the TriplEx clone by using Pfu DNA polymerase (Stratagene) and the upstream primer (5¢-TTTTTT CTCGAGAAGCTTTCC CTGCAGGAT-3¢) and downstream primer (5¢-TTTTT T GGATCCCTACAGATGTGCTTCAAGGCC-3¢), ... he amount of product released in test incubations. For estimations of the apparent af®nity (K m ) and k cat , steady-state rates were determined over a range...

Ngày tải lên: 08/03/2014, 16:20

... oligonucleotides of 5¢-GCAGCAAATGAGC CCAGGTACACCTGTTCC-3¢ and 5¢-GGAGGGCACC CACATGTTCCCATGC-3¢ were used as the forward and reverse primers. Similarly, oligonucleotides of 5¢-AAGTAT AACTCTCGAGCCCTCCACATCAAGG-3¢ ... us with another important enzyme target in the topoisomerase I pathway for therapeutic intervention. TDPwasfirstnotedasanenzymeinyeastwithactivity that specifically cleav...

Ngày tải lên: 31/03/2014, 21:21

... with significant increases in both bone for- mation rate and mineral apposition rate in the tibiae of rats treated with cerivastatin at 0.1 mg/kg/day. Statins, there- fore, have the potential to ... 3- hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reduc- tase enzyme. These include naturally occurring lovastatin, chemically modified simvastatin and pravastatin [1–3] and the synth...

Ngày tải lên: 09/08/2014, 03:24

... 5' ATT TCT GGC TTC TAG TCT GGT GTT C 3' 5' ACT TGA TTT CAG GTC AAT AAC GGT CCC C 3' 5' AAC GTG CCA GTG TGG AGT GA 3' 0.163 MMP-3 5' TGA AGA GTC TTC CAA TCC ... TCC TAC TGT TG 3' 5' CGT GGC AGT TTG CTC AGC CTA TCC AT 3' 5' CTA GAT ATT TCT GAA CAA GGT TCA TGC A 3' 0.108 MMP-9 5' CCC GGA GTG AGT TGA ACC A 3' 5' ....

Ngày tải lên: 09/08/2014, 06:22

... receptor; TRAF, TNF receptor-associated factor. Intact upstream activators of the classical and alternative pathways of NF-κB are also essential for normal lymphoid organization and establishment of self-tolerance. ... [1-6]. These pathways are termed the ‘classical’ or ‘canonical’ pathway and the ‘alternative’ or ‘noncanonical’ pathway. The classical nuclear factor- κκ B pathwa...

Ngày tải lên: 09/08/2014, 10:23

... features of the pharmacophore model used as the 3D query in datab ase searching was retai ned as a hit. Two database searching options such as Fast/Flexible and Best/Flexible search are available ... hypothesis and the total cost. The larger the difference between the cost of the null hypothesis and total cost, the greater the likelihood that the correlation between the fit...

Ngày tải lên: 10/08/2014, 05:21