Báo cáo y học: "Homing chemokines in rheumatoid arthritis" doc
Báo cáo y học: "Homing chemokines in rheumatoid arthritis" doc
... important in retaining
the cells at this site [17,18].
In about 20% of patients with RA, infiltrating T and B lym-
phocytes accumulate underneath the synovial lining layer
and organize into lymphocyte ... The
induction of BCA-1 and other lymphoid-tissue-inducing
chemokines may convert the synovial lesion from an acute
to a chronic state by amplifying antigen-specific
responses. Blocking...
Báo cáo y học: " Autoantibody profile in rheumatoid arthritis during long-term infliximab treatment" pdf
... the
amount of synovium infiltrating cells, including plasma cells
[39]. Because RF-producing cells are present in inflamed
rheumatoid synovium and the local environment may favour
synovial RF production ... phenomenon, lasting about 1 year. This might
explain why almost all of the infliximab-induced lupus syn-
dromes were reported within the first year of treatment in
RA.
No differences...
Báo cáo y học: "Infliximab therapy in rheumatoid arthritis and ankylosing spondylitis-induced specific antinuclear and antiphospholipid autoantibodies without autoimmune clinical manifestations: a two-year prospective study" potx
... the cytokine network in such
induction has already been demonstrated for another
cytokine, interferon γ, inducing the development of autoan-
tibodies in patients with hepatitis C viral infection ... anti-
inflammatory effects of infliximab have led to their use in
other inflammatory diseases such as Crohn's disease [5]
and ankylosing spondylitis (AS), with a similar efficacy to
tha...
Báo cáo y học: "B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response" docx
... DRB1
In the initial, retrospective study, the frequency of B cells
was determined as a percentage of CD19
+
lymphocytes
from total T lymphocytes and B lymphocytes combined
(CD3
+
+ CD19
+
lymphocytes). ... The clinical relevance of B
lymphocytopenia in SE-positive RA will be further investigated
in longitudinal studies.
Keywords: antibodies, B lymphocytes, major histocompatibility compl...
Báo cáo y học: "Myocardial dysfunction in rheumatoid arthritis: epidemiology and pathogenesis" pps
... RA-induced and RA therapy-induced
hyperhomocysteinemia to CHF risk in RA has yet to be
completely elucidated.
Inflammatory cytokines
In patients with overt CHF, levels of inflammatory cytokines
(TNF-α, ... an
endocrine (originating in the synovium) or paracrine (produced
in the local environment of the progressively failing
myocardium) fashion, contributing to subclinical and eventual...
Báo cáo y học: "Bone erosions in rheumatoid arthritis can be repaired through reduction in disease activity with conventional disease-modifying antirheumatic drugs." pot
... A, et al.: Min-
imal clinically important difference in radiological progression
of joint damage over 1 year in rheumatoid arthritis: preliminary
results of a validation study with clinical experts. ... 3
Probability plot: change/year in total radiographic scoreProbability plot: change/year in total radiographic score.
Figure 4
Probability plot: change/year in erosion scoreProbabi...
Báo cáo y học: "Epigenetic modifications in rheumatoid arthritis" pptx
... modifications regulating
inflammatory processes
The transcription factor NF-κB plays a central role in the
induction of genes involved in immunity and inflammation,
including cytokines, chemokines, adhesion ... regions. Methyl CpG-binding
proteins use transcriptional corepressors for transcriptional
silencing or may modify the surrounding chromatin of
methylated regions [27]. In oncoge...
Báo cáo y học: "Sinus aspergilloma in rheumatoid arthritis before or during tumor necrosis factor-alpha antagonist therapy" ppsx
... In our study, CT of the sinuses was performed
only to investigate symptoms. Sinus aspergilloma may remain
asymptomatic for several years, however, and may therefore
be underestimated.
Sinus involvement ... Aspergillus may be either invasive or
noninvasive. Invasive sinus aspergillosis may be indolent or ful-
minant. Noninvasive Aspergillus sinusitis may manifest as aller-
gic fungal sinusit...
Báo cáo y học: "Rituximab treatment in rheumatoid arthritis: how does it work" pdf
... anti-citrullinated protein
antibodies), which can be found already in the preclinical
phase of the disease; the presence of lymphocyte aggre-
gates containing B cells, which are often surrounded by large
numbers ... cytotoxicity plays a dominant role in
B cell depletion in the splenic marginal zone B cell compart-
ment, whereas Fc receptor mediated mechanisms (like
antibody-dependent ce...
Báo cáo y học: " Forefoot pathology in rheumatoid arthritis identified with ultrasound may not localise to areas of highest pressure: cohort observations at baseline and twelve months" ppt
... MTP joint synovial hypertrophy and
forefoot bursal hypertrophy (Table 7). This suggests that the pattern of presence of MTP joint
synovial hypertrophy and forefoot bursal hypertrophy within the ... predominantly medial. Plantar forefoot bursal
hypertrophy has been reported previously in the parent FeeTURA study [7, 8] and in this sub
analysis was also predominantly lateral at both bas...