Báo cáo y học: "Production of interleukin-1 receptor antagonist by human articular chondrocyte" ppt

... production of sIL-1Ra by chondrocytes may have a protective effect against articular inflammatory and catabolic responses. Keywords: cytokines, glucocorticoids, human articular chondrocytes, IL-1 receptor ... article Production of interleukin-1 receptor antagonist by human articular chondrocytes Gaby Palmer 1 , Pierre-Andre Guerne 1 , Francoise Mezin 1 , Michel Maret...

Ngày tải lên: 09/08/2014, 03:24

... days of restricted activity, more than 5,000 deaths, and 470,000 hospitalizations each year. 1 Previously characterized as a disease of air- way smooth muscle, asthma is currently defined by ... or by targeting enzymes involved in leukotriene biosynthesis. Zileuton is a 5-lipoxygenase inhibitor that inhibits the formation of LTA 4 from arachidonic acid, thereby preventing cysteinyl...

Ngày tải lên: 08/08/2014, 20:23

... surface by directly bind- ing leukocyte β2-integrin Mac-1 and thereby decreasing influx of inflammatory cells into the joint cavity, functioning as an immune surveillance mechanism. Lower levels of ... inflammatory synovitis that is dominated by the presence of macrophages, lym- phocytes and synovial fibroblasts, which leads to the destruc- tion of bone and cartilage. The pathogen...

Ngày tải lên: 09/08/2014, 06:23

... of stimulatory and inhibitory Fcγ receptors on human monocytes by Th1 and Th2 cytokines. J Immunol 2001, 166:531-537. 8. Ravetch JV, Lanier LL: Immune inhibitory receptors. Science 2000, 290:84-89. 9. ... ultimately be required. The FcγRs play important roles in the initiation and propaga- tion of many different immunological and inflammatory proc- esses. Consequently, they may act as...

Ngày tải lên: 09/08/2014, 07:20

... attributed to the release of histamine, 5-hydroxy- tryptamine and bradykinin, followed by a late phase (1-6 h) mainly sustained by PG release due to the induction of cyclooxygenase 2 (COX-2) in the ... the role of the LXR receptor in the pathophysiology of acute inflammation. Our results imply that LXR agonists may be useful in the therapy of inflammation. Abbreviations (L×R):...

Ngày tải lên: 12/08/2014, 11:20

... model of pulmonary hypertension and found that the inhibition of CXCR4 activity significantly decreased hypoxia-induced pulmon- ary hypertension. Interestingly, Gambaryan et al. most recently reported ... important pathological feature of pulmonary hypertension is increased medial thickening of pulmonary artery result- ing from hypertrophy and hyperplasia of the pulmonary artery smo...

Ngày tải lên: 12/08/2014, 13:22

... Because this pattern of association could be explained by combinations of haplotypes car- ried, we explored the effect of diplotypes further. Among all diplotypes of frequency > 0.05, HHD/HHE showed ... other haplotypes is only frequent enough in persons of African ancestry. The relatively higher frequency (7%) of HHD/ HHE in our population than in Caucasians or other smaller...

Ngày tải lên: 13/08/2014, 01:20

... paralleled by a reduction of its intracellular level presumably caused by the Vif-induced proteasome-dependent degradation of APOBEC3G. Results: In this report we employed confocal microscopy to study ... heads). Overlay of the Vif and APOBEC3G channels revealed a partial co-localization of Vif and APOBEC3G in the cyto- plasm apparent by the yellow staining in panels C & F...

Ngày tải lên: 13/08/2014, 13:20

... acetic ether were used at the ratio of 2:1. The purity was estimated by use of thin-layer chromatography. Cleavage of the tert-butyl ester. 2 mmol tert-butyl pro- tected PNA building block functionalized ... reacts with 9 to the tert-butyl ester of the peptide nucleic acid monomer (Fmoc protected) 10 as a reaction product. After hydrolysis of the tert-butyl ester, catalyzed by...

Ngày tải lên: 26/10/2012, 08:57

... mixtures of methyl glycosides were analyzed on GLC [14,15]. The absolute configurations of the monosac- charides were determined by GLC analysis of the trimeth- ylsilylated (–)-2-butyl glycosides ... neutralization and removal of boric acid by coevaporation with methanol, the mixture of partially methylated alditols was acetylated with acetic anhydride (3 h, 120 °C), and analyzed...

Ngày tải lên: 08/03/2014, 09:20