Báo cáo y học: "Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener’s granulomatosis" pptx
Báo cáo y học: "Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener’s granulomatosis" pptx
... epiphenomenon[10]. One of the unresolved issues is the inability toexplain the nonrandom, selected organ injury that defines the WG vasculitis and the concurrent, seemingly random,nature of injury within ‘targeted’ ... the PR-3 expression in normal lung and lung tissue of WG patients, as the lung is the most frequent organ involved in WG [15]. In normal lung tissue, mainly pneumocytes type Iand type II and just ... kidney, nose and lung) . Little is knownabout the expression and distribution of PR-3 in the lung. We found that PR-3 is expressed in normal lung tissue and is upregulated in lung tissue of patients...
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Báo cáo y học: "CD134 as target for specific drug delivery to T cells in adjuvant arthritis" pps
... during priming in situ; that is, in the secondary lymphoid organs. When anti-CD134 liposomeswere injected s.c. in the hind paws, the majority of the CD4+CD134+ T cells in the joint-draining ... participated in the design of the study and in its coordination. LE participated in the experiments, statistical analysis and interpretation of the results. MW supervised the design and execution of the ... online http://arthritis-research.com/content/7/3/R604R612 the joints, where they subsequently become involved in jointinflammation. The second increase in the percentage of CD134-expressing...
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Báo cáo y học: " Human herpesvirus 6 major immediate early promoter has strong activity in T cells and is useful for heterologous gene expression" ppsx
... than the promotercontaining only intron 1. Further investigation is neededto elucidate the mechanisms involving the intronregions.We recently developed a recombinant VZV vaccinestrain containing ... containing the mumps virus HN gene. In thisstudy, we examined whether the HHV-6 MIEp contain-ing intron 1 functioned as a heterologous expressionpromoter in the VZV vaccine strain. Indeed, in the recombinant ... representation of the HHV-6MIE promoter variants, including introns 1-4 of the IE1 gene, usedfor analysis of the introns. The numbers indicate the nucleotideposition from the 5’ end of mRNA encoded by the...
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Báo cáo Y học: An alternative model for photosystem II/light harvesting complex II in grana membranes based on cryo-electron microscopy studies pptx
... 1A). In the classical view of plant photosynthesis, one part of the photosyntheticelectron transfer chain (photosystem II) is segregated into the grana, whilst other components of the system ... loops of core polypeptide CP47 [15]. A furtherdomain (V) underlying and contributing to domains II and Iwas assigned to the lumenal portion of CP43. In the X-raystructure of the core complex of ... lightenergy is mainly trapped by the light harvesting complex II(LHCII), which consists of several related proteins of mass 25 kDa [4]. One of the proteins, LHCIIb, is present in high stoichiometry...
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Báo cáo y học: " Cigarette smoke exacerbates mouse allergic asthma through Smad proteins expressed in mast cells" pps
... tryptase contained in mastcell granules and Smad3 protein in lung tissues usingdouble staining. As shown in Figure 7A, lung tissues in OVA/S mice enhanced the co-localization (yellowcolor) of ... of mast cell tryptase and Smad3 protein in lung tissues In order t o investigate whether smoke-induced expres-sion of Smad proteins was occurring in mast cells, weexamined co-localization of ... com-plexity. The relationship between OVA/NS and OVA/Smice was determine d by linear regression analysis. The r2wasusedasameasureofhowwellthedatafittheregression line. The densitometry analysis of...
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Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"
... because they are not hydrolysed by β-glucosidases in the intestine and can be adminis-tered orally [27]. Therefore, the aim of the present study was to evaluate the inhibitory effect of some ... [16]. It in- hibits the activity of SGLT in the kidney leading to glycosuria [17]. Its clinical application; however, is restricted due to hydrolysis by β-glucosidases in the intestine [12]. ... suggesting that differences in the aglycon binding site play an important role in the in- hibitory effect of this substance. In contrast, differ-ences in the sugar binding site resulted in an...
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Báo cáo y học: "GWASs and the age of human as the model organism for autoimmune genetic research" doc
... SNPs [20]. On the basis of the hypothesis that disease alleles reflect the allelic spectrum of diseases in the general population, the risk of common diseases will be attributable in part to allelic ... population, but increase the disease risk by only 10 to 20% (corresponding to an odds ratio (OR) of 1.10 to 1.20 per copy of the risk allele). (e OR is a measure of the strength of association; ... and stability of IRF5 mRNAs [30]. Haplotypes of these three variants define at least three distinct levels of risk to SLE. ere is an approximately twofold increase in the level of risk between...
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Báo cáo y học: "Capnography as an aid in localizing the phrenic nerve in brachial plexus surgery. Technical note" potx
... very difficult especially when this key mus-cle is fibrosed and merges with the surrounding neuroma. The muscle is then indirectly identified as the tissue lyingbehind the phrenic nerve. The ... weremonitored by the neuroanesthetist as the stimulating cur-rent was gradually increased. Simultaneously, the pres-ence of diaphragmatic contraction was judged by the surgical assistant with his hand ... repair of the injured nerves. Conse-quently, muscle relaxants were avoided. Anaesthesia wasinduced with propofol and fentanyl and the airway wassecured with a laryngeal mask. Anaesthesia was main-tained...
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Báo cáo y học: "Dermoscopy as a technique for the early identification of foot melanoma" pot
... new cases annually and around 66 000deaths. Globally the incidence of the disease continues torise, particularly in Caucasian populations [1]. As there is no effective treatment for the disease, ... useful screening tool for health care professionalsinvolved in skin care. On this basis, dermoscopy is poten-tially a new extension to the scope of practice in Podiatry. In theory, podiatric ... (figure 4). In each of these the pigment is located in the furrows of the plantar dermatoglyphics. The patternsarise as a reflection of normal melanin columns in the stratum corneum in a vertical...
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Báo cáo y học: "EXACKTE2: Exploiting the clinical consultation as a knowledge transfer and exchange environment: a study protocol" pptx
... effect )as well as on the physician's level of uncertainty (the partnereffect) while controlling for the influence of the essentialelements of SDM assessed on the part of the physician(Figure 1). In ... elements of SDMassessed on the part of the patient; and the influence of the essential elements of SDM assessed on the patient parton the patient's level of uncertainty (the actor effect )as well ... part on the physician's level of uncertainty (the actor effect) as well as on the patient'slevel of uncertainty (the partner effect) while controllingfor the influence of the essential...
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