Báo cáo y học: "Differential expression of the angiogenic Tie receptor family in arthritic and normal synovial tissue" doc

... play important roles principally during the later stages of angiogenesis. We have compared the distribution of the receptor tyrosine kinase (Tie) and the Ang ligands in synovial tissues from normal ... mRNA and protein levels in RA synovial tissue compared to that from patients with OA and normal subjects. Hypothetically, in RA synovial tissue the dominat...

Ngày tải lên: 09/08/2014, 03:24

... pFAK and pPyk2. Our findings suggest that the colocalization and activation of FAK, Pyk2, Src and paxillin in RA and OA patient's ST lining and sublining may be important for integrin-mediated ... kinase (FAK) and proline-rich tyrosine kinase (Pyk)2 are two members of a family of nonreceptor protein tyrosine kinases that are acti- vated by a variety of extracell...

Ngày tải lên: 09/08/2014, 10:21

... (1997) The crystal structures of Sinapis alba myro- sinase and a covalent glycosyl±enzyme intermediate provide insights into the substrate recogn ition and active-site machinery of an S-glycosidase. ... 2002 20 lL of the enzyme/inhibitor mixture to 180 lLof substrate (4NPGlc), incubating for 30 min at 37 °C, and measuring the rel ease of 4NP. Protein assays and protein...

Ngày tải lên: 08/03/2014, 16:20

... that the induction of the anaerobic proteins is the result of a n increased mRNA level. Maize (Zea mays L.) responds to anaerobic stress by redirect- ing t he synthetic machinery towards the synthesis ... very rapid increase of the hydA transcript was detected in the first 3 0 min of anaerobiosis. This quick increase of gene transcription is only reported for the cyc6...

Ngày tải lên: 08/03/2014, 22:20

... chemokines direct lymphocytes into the chronically inflamed synovial tissue [7,8]. Both the residual synovial- lining cells and infiltrating leuko- cytes are the source of pro-inflammatory chemokines ... analyzed. Expression levels of chemokine receptors were measured by flow cytometry and were compared between the different patient groups and healthy individuals. The...

Ngày tải lên: 09/08/2014, 06:23

... border and the combined expression of α v β 3 integrin and of certain enzymes (carbonic anhydrase II, vacuolar ATPase, cathepsin). This lends support to the hypothesis that neutrophils could be involved ... out of nine healthy subjects studied). The expression of TRAF6 by normal blood neutrophils, on the other hand, was detected in all the conditions tested but...

Ngày tải lên: 09/08/2014, 10:20

... signals) by members of the cytosolic Nod- like receptor (NLR) family of cytosolic pattern recogni- tion receptors (PRRs) [6-10]. The largest subfamily of NLRs contains a PYRIN domain (PYD) as an ... connects the PYD and the CARD in ASC is lacking in the smaller protein (Figure 1B). Furthermore, a polyclonal antibody raised against amino acid residues 2 to 27 of th...

Ngày tải lên: 11/08/2014, 03:20

... amounts of sialylated Hex3 glycoforms were indicated. b Minor amounts of Hex2 and Hex3 glycoforms lacking acetyl groups or containing a second glycyl group were indicated. c Very minor amounts of ... removal of acetate and glycine, con- firming glycine to be e ster-linked. Information on the location of the a cetyl and glycyl groups as well as glycose sequence was provided...

Ngày tải lên: 31/03/2014, 21:21

... San Leandro, CA, USA), and the inten- sity of the L-PGDS bands was normalized by dividing them by the intensity of the β-actin band of the corresponding sample. 11β-PGF 2 α and PGD 2 assays The ... about the expression and regulation of L-PGDS and H-PGDS in carti- lage. To better understand the role of PGD 2 in the joint, we investigated the expres...

Ngày tải lên: 09/08/2014, 01:22