Báo cáo y học: "Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on κ α NF-κB binding activity and TNF-α secretion of T cell" pot

... delayed-type hypersensitivity to Mycobacterium tuberculosis, increased the in vitro tumor necrosis factor (TNF) -α secretion, and more strongly induced NF-κB binding activity after anti-CD4 preincubation ... ‘accelerating’ (although this term is applicable only to the onset of AA) and the mAbs W3/25 and OX35 as ‘ameliorating’. Affinity of the monoclonal antibodies...

Ngày tải lên: 09/08/2014, 03:24

... data to support the hypothesis that the decrease in endorphin concentration precedes the onset of inflammation, acting as a putative cofactor for disease development. The serum concentrations of ... separated by 2 minutes, with a current of 100 V/cm.) Injection of CFA Arthritis was induced by injecting 0.3 ml of 5.0 mg/ml CFA (consisting of heat-killed Mycobacterium butyri...

Ngày tải lên: 09/08/2014, 01:23

... usual medications Intra-articular corticosteroid injections in the target knee within the last 3 months Viscous injections in the target knee within the last 6 months Hypersensitivity to NSAIDs ... unwilling to stop taking other medications for the treatment of OA Any other condition that, in the opinion of the investigator, would adversely affect the subject's ability to...

Ngày tải lên: 26/10/2012, 09:48

... from the literature. The clinical utility of genetic testing in PID disorders The benefits of PID genetic testing are listed in Appendix 1. This distinction is artificial as the value to patients ... rarely, skewed lyonisation may be a consequence of mutations at the Xist locus, which initiates X-chromosome inactiva- tion. In this situation the wild type allele may be selec-...

Ngày tải lên: 08/08/2014, 21:20

... ,or esophageal hypomotility and is more often associated with limited cutaneous involvement [106]. Thus the clinical utility of determining aCL in patients with SSc has not yet been established. Antibodies ... diagnostic value that anti- histone antibodies have in other CTD (with the highest Available online http:/ /arthritis- research.com/content/5/2/80 81 Available online ht...

Ngày tải lên: 09/08/2014, 01:21

... associated with the presence of IgG anti-dsDNA only in two patients at the 24th week and in four patients at the 48th week after treatment. None of the patients with RA treated only with methotrexate displayed ... the tender and swollen joint counts and the ESR and CRP values during the study. The group of patients treated with methotrexate alone displayed a stable disease...

Ngày tải lên: 09/08/2014, 07:20

... B-level activity in the majority of patients presenting with more serious disease, including patients with B-level activity in several body systems. The current data limit the conclusions that can ... evidence of onset of recovery by the final study evaluation at 32 weeks (6 months post-treatment). In contrast, there does not appear to be any consistent pattern of decrease...

Ngày tải lên: 09/08/2014, 08:22

... ALT: Alanine aminotransferase Competing interests The author(s) declare that they have no competing inter- ests. Authors' contributions WM participated in the design of the study and statistical analysis. ... ART, 11.3% of patients in the present study developed skin rashes in which lead to permanent discon- tinuation of NVP. This rate is similar to that in the previ- o...

Ngày tải lên: 10/08/2014, 05:20

... parents of the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor -in- Chief of this journal. Competing interests The ... is very important. Physical therapy and daily exercise may improve mobility of joints. Blood transfusion, infection and nutritional management are also important...

Ngày tải lên: 11/08/2014, 12:20

... course of the study. Statistical Analysis All d ata were entered into a single, electronic database. Statistical Analysis was done with Statistica version 9 software (Statsoft, Inc 2009). As some of ... program. Conclusion This is the first study of its kind conducted in a develop- ing country. The results indicate that assertive interven- tions in this setting need not consume re...

Ngày tải lên: 11/08/2014, 16:22