Báo cáo y học: "Statins as modulators of bone formation" pot

... for chronic disease. A nested case–control study using a UK-based general practice research database has also shown that current use of statins was associated with a reduced risk of frac- ture ... addition, both simvastatin [11] and pitavastatin [12] increased human osteoblast differentiation as measured by, respec- tively, alkaline phosphatase expression and mineralisation or expressio...

Ngày tải lên: 09/08/2014, 03:24

... chemical synthesized [13, 14]. The most commonly used is known as T-1095 (3-(benzofuran-5-yl)-2',6'-dihydroxy-4'-methylpropio- phenone 2'-O-(6-O-methoxycarbonyl-β-D-glyco- pyranoside) ... they are not hydrolysed by β-glucosidases in the intestine and can be adminis- tered orally [27]. Therefore, the aim of the present study was to evaluate the inhibitory effect...

Ngày tải lên: 26/10/2012, 10:04

... polyarthritis at the time of treatment initiation. The fourth monkey was in a preclinical phase of the disease, as shown by elevation in serum acute phase reactants and synovial inflammation by arthroscopy. ... produce a variety of proinflammatory cytokines, which results in proliferation of synovial tissue associated with destruction of cartilage and bone. Tissue destruction in...

Ngày tải lên: 09/08/2014, 01:21

... test. Results Validation of systemic and local inflammation Patients were investigated for systemic as well as local inflam- mation and disease activity by the analysis of blood and syno- vial tissue samples. Systemic ... Activity of arthritis was determined by routine parameters for systemic inflammation, by histological scoring of synovitis and by semiquantitative RT-PCR of IL...

Ngày tải lên: 09/08/2014, 07:20

... osteocytes [39-41]. In bone, OPN produced by OB during bone matrix formation is subsequently accumulated in the mineralised matrix. Increased OPN may augment OB synthetic activity by increasing ... disease. The differen- tial gene expression of ALP, OCN, OPN, and the alpha chains of collagen type I in OA observed from this study suggests support of the hypothesis of increased OB bi...

Ngày tải lên: 09/08/2014, 08:23

... need that could potentially be addressed by hybridization-based target enrichment. 14 CEU father, YRI mother, and YRI father, respectively) [13]. When we measured the depth of coverage over ... in the genotyping sensitivity of our method based on the two types of gold standards. However, as reflected in our coverage results, we observed that the genotyping sensitivity associa...

Ngày tải lên: 09/08/2014, 23:20

... superiority of a combined assessment of the systolic and early diastolic mitral annular velocities by tissue Doppler imaging for the differenti- ation of restrictive cardiomyopathy from constrictive ... artery (LAD) by primary PCI were retrospectively enrolled in this study. Inclusion criteria were AMI caused by LAD oc- clusion (type I, ESC) and coronary artery disease af- fecting...

Ngày tải lên: 25/10/2012, 11:15

... localization of the farnesylated and the nonfarnesylated forms of Mydj2 protein by Western blotting analysis, using the same anti-dj2 Ig as in immuno- fluorence experiments. As shown in F ig. 5 , Mydj2 ... pQE-32-Mydj2) was v erified by DNA sequencing, and the plasmid was subsequently used to overexpress M ydj2–6·His in Escherichia coli. Expression and purification of histidine-tagged...

Ngày tải lên: 17/03/2014, 17:20

... course of substrate hydrolysis was followed by monitoring the fluorescence released from the beads as the CFPs were cleaved in their substrate linker. Percentage of hydrolysis was calculated as the ... chemotherapy as well as accelerate the discovery of new targets. Phage display has already opened new avenues in kallikrein research that may further reinforce the role of hK2 in...

Ngày tải lên: 31/03/2014, 23:20

... 30-year period, Menzel noted a lengthen- ing of the growing season by +0.36 day/year (an advancement of spring by 6.3 days and a delay in fall of 4.3 days). 48 It was also noted in this study ... been performed. Polar areas or areas of colder climates seem to be particularly susceptible to warming, as evidenced by studies of plant phenophases in these areas. 46 In a phenologic sur...

Ngày tải lên: 08/08/2014, 21:20