Báo cáo khoa học: "Recent advances in the surgical care of breast cancer patients" pps

Báo cáo khoa học: Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding pdf

... the substrate via twoelements in ClpA, one in the N-domain and the other in the pore of the ClpA hexamer. In the case of shortunstructured peptides or unfolded proteins such ascasein, binding ... have analysed the role of ﬁve highly conserved basic residues in the N-domain of ClpA by monitor-ing the binding, unfolding and degradation of several different substrates,including short unstructured ... threedomains: an N-domain and two ATP-binding domainsreferred to as the D1 and D2 domains. Interestingly,deletion of the N-domain from ClpA not only abol-ishes binding of the adaptor protein, ClpS, but...

Báo cáo khoa học: "Some Problems in the Mechanical Translation of German" pdf

... ent. These arise with verbs of perceiving and certain others such as "permitting," when the substantive which is the direct object of the main verb is also the subject of the infinitive. ... the feminine singu- lar dative. 2. The masculine singular accusative of wel- cher is identical to the dative plural. 3. The nominative form is identical to the ac- cusative in the feminine ... 4 . In the case of those that are de- pendent, the substantive on which they depend is — on an average — in 20 per cent of the instances the subject, in 25 per cent of the instances the...

Báo cáo khoa học: An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist docx

... Biochem. 270) Ó FEBS 2003 An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist Stuart R. Hawtin1,*, Victoria J. Wesley1, ... UKDeﬁning how the agonist receptor interaction diﬀers fromthat of the antagonist receptor and understanding the mechanisms of receptor activation are fundamental issues in cell signalling. The ... antag-onist binding [14]. The corresponding residue in the OTR is also an arginyl (Arg34) and furthermore this arginyl is required for high afﬁnity agonist binding to the OTR[15]. Indeed, an...

Báo cáo khoa học: Local changes in the catalytic site of mammalian histidine decarboxylase can affect its global conformation and stability pptx

... for the dimer.Ó FEBS 2003 Conformational changes of histidine decarboxylase (Eur. J. Biochem. 270) 4379 Local changes in the catalytic site of mammalian histidine decarboxylase can affect its global ... decarboxylation and elimination of the ﬂuoride, a reverse transaldimination can occur, so that anenamine form of the product can either leave the catalytic site or react again with the internal aldimine ... analogs in the active center. Furthermore,these ﬁndings also seem to indicate that the analogs can Fig. 5. Scheme of the HDC reactions with the natural substrate histidine and the histidine- analogs...

Báo cáo khoa học: Netropsin interactions in the minor groove of d(GGCCAATTGG) studied by a combination of resolution enhancement and ab initio calculations pot

... interactions FEBS Journal 272 (2005) 35313541 ê 2005 FEBS 3533 Netropsin interactions in the minor groove of d(GGCCAATTGG) studied by a combination of resolution enhancement and ab initio calculations Kristof ... (NAE) wasinvestigated by evaluating the interaction energies and hydrogen positions of the end fragment and the bases of base pair T8 -A2 5 and base G9 (Table 2, Fig. 4).For the bases of the A2 5-T8 ... area of the NAE has been studied by evalu-ating the effect of adenine A2 5, thymine T8, guanine G9 and one water molecule, W57, on the change of the totalenergy. The NGE, has also been examined...

Báo cáo sinh học: " Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies" doc

... Corresponding author AntiviralsCell biologyMolecular virologySARS-CoVVaccinesAbstract In the aftermath of the SARS epidemic, there has been significant progress in understanding the molecular and cell ... SARS-CoV and the receptor-binding sites on the virion are located in the 12–672 amino acid region of the S protein [43]. Current advances towards SARS-CoV prevention strategiesDuring the SARS ... Althoughprogress in SARS-CoV molecular and cell biology researchhas been remarkable, there remain clear limitationsregarding vaccine development due to a lack of completeunderstanding in the areas of animal...

báo cáo hóa học:" Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies" pot

... biologyMolecular virologySARS-CoVVaccinesAbstract In the aftermath of the SARS epidemic, there has been significant progress in understanding the molecular and cell biology of SARS-CoV. Some of the ... surface. The virus enters the cell, uncoats, and the viral RNA is replicated and translated. The SARS-CoV U122 protein induces apoptosis in cells. SARS-CoV S and N proteins each can activate the cellular ... SARS-CoV and the receptor-binding sites on the virion are located in the 12–672 amino acid region of the S protein [43]. Current advances towards SARS-CoV prevention strategiesDuring the SARS...

Báo cáo khoa học: "Recent advances in the surgical care of breast cancer patients" pps

... 5years at the multivariate analysis [237]. In the US this information has resulted in a rapidincrement of Breast Fellowship, recognizing that appro-priate training is one of the key factors in improvingquality ... haveresulted both in an increasing percentage of small breast cancers found at the initial diagnosis and in a smalldecline in mortality [2].Howewer, as the current goal for breast cancer patients ... a great deal of information, and to manage increasingly complex tasks.As a comprehensive assessment of all aspects of breast cancer care is beyond the scope of the present paper, the current...

Báo cáo khoa học: "Ruptured gallbladder as the first presentation of breast cancer" docx

... Perforation of the gall bladder as a first presentation of breast cancer has not beenreported.Case presentation: Here we present a case of an elderly lady with acute abdomen with evidence of possible ... carcinomas of the breast have higher prevalence of spread to gastrointestinal tract compared to their ductalcounterparts [1]. Although breast cancer metastasis to the gall bladder has previously ... cancer, and breast cancers [8].Lobular cancers of the breast are well known to metasta-sise to the gastrointestinal tract compared to ductal can-cers, and metastasis to the gallbladder has previously...

báo cáo khoa học: "Recent advances in gastrointestinal oncology updates and insights from the 2009 annual meeting of the American Society of Clinical Oncology" doc

... REVIEW Open AccessRecent advances in gastrointestinal oncology - updates and insights from the 2009 annual meeting of the American Society of Clinical Oncology Milind Javle1, Chung-Tsen Hsueh2*AbstractWe ... Clin Oncol (Meeting Abstracts) 2009, 27(18S):LBA4007.56. Javle M, Hsueh CT: Updates in Gastrointestinal Oncology - insights from the 2008 44th annual meeting of the American Society of Clinical Oncology. ... have reviewed the pivotal presentations related to gastrointestinal malignancies from 2009 annual meeting of the American Society of Clinical Oncology with the theme of “personalizing cancer care”....

Báo cáo khoa hoc:" Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma progression" potx

... number not for citation purposes)Journal of Negative Results in BioMedicineOpen AccessResearch Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma ... combined into a single variable, the 'phe-notypic index' [17]. This index, with minimum and max-imum values of 1 and 5, represents the sum of pointsassigned to the following phenotypic ... the genotyping, participated in the selection of SNPs, analysis, and prepared the manuscript; PR and SSparticipated in the genotyping; AP coordinated the patients' accrual and updated the...

Báo cáo khoa hoc:" Perfluorodecaline residue in the anterior chamber of a patient with an intact crystalline lens: a case report" ppt

... male with an intact crystalline lensFigure 2Colour images of perfluorodecalin residue in anterior cham-ber of a 17-year-old male with an intact crystalline lens.Colour images of the retina ... before and after operationFigure 1Colour images of the retina before and after operation. (a and b) Giant retinal tear with shallow detached retina involving the macula in the right eye. (c) Reattachment ... (4)After our attempt to remove the perfluorodecaline in the anterior chamber with a 27G needle failed, an anterior chamber wash was performed with balanced salt solutionvia two wide paracentesis....

báo cáo khoa học: " Recent advances in the genetics of language impairment" docx

... diﬃculties controlling the movement and sequencing of orofacial muscles, causing deﬁcits in the production of ﬂuent speech. In- depth studies of the KE family showed that, in these individuals, speech ... understanding of language disorders and improve our understanding of the biological foundations of language acquisition.â 2010 BioMed Central Ltd Recent advances in the genetics of language ... path-ways and the inherent diﬃculties of precisely deﬁning them in the laboratory.FOXP2 in the braine expression of FOXP2 is not limited to the brain but is also seen in several other organs,...

báo cáo khoa học: " Pharmacogenomic considerations in the opioid management of pain" pot

... renal epithelial cells and also on the luminal side of endothelial cells in the blood-brain barrier, and it is a major determinant of the pharmaco-kinetics and pharmacodynamics of several opioids ... standard of care for anesthesiologists and pain management physi-cians. In the near future, pharmacogenomic approaches in pain management could lead to individualized therapy to best select the ... management Genomic variations clearly in uence pain sensitivity, the likelihood of developing chronic pain and the response to pharmacotherapy for the management of pain [21,22]. Pharmacogenomic polymorphisms...

Báo cáo y học: " Recent advances in the investigation of curcuminoids" doc

... enhancedanti-inflammatory activity. The increased size of the cyclo-alkanone ring, by replacing the cyclopentanone in 27 witha cyclohexanone in 25, increased inhibitory potency.However, this ... HIV-1 integrase is the enzyme that catalyzes the integration of the double-strained DNA of HIV into the host chromosome [54].Curcumin inhibited this activity of HIV-1 integrase [54].Other classes ... potent in the lipid peroxidation assay, indicatingthat steric hindrance at the positions flanking the hydroxyl group decreased anti-oxidative activity. Chang-ing the 3'-methoxy group in curcumin...

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