... and compounds synthesized in this study. Chemical structures of SAM, MTA, sinefungin, AMI-1, AMI-6,AMI -9 and compounds 1-5.Table 1. Inhibition of histone methylation by PRMT1 and PRMT4 in the ... SAM is the methylation donor in the PRMTreaction, the use of SAM analogs is a logical strategyfor the direct inhibition of PRMTs. As a SAM analog,sinefungin can compete for SAM binding and inhibit the ... conveyed to the aminonaphthol sulfonate core of AMI-1 byappending the azo moiety of AMI -9 to one side, givingcompound 1, and the dichlorotriazine group of AMI-6to the other side, giving compound...