báo cáo khoa học: "The role of 18F-FDG-PET/CT in the preoperative staging and posttherapy follow up of gastriccancer:Comparison with spiral CT" docx

... Open Access The role of 18F-FDG-PET/CT in the preoperative staging and posttherapy follow up of gastriccancer: Comparison with spiral CTElgin Ozkan, Mine Araz*, Cigdem Soydal and Ozlem N KucukAbstractBackground: ... limitation th at the number of patients issmall especially in the first group, the number of studiesintheliteratureinvestigatingtheroleofPETinthediagnosis of distant metastasis preoperatively ... therapyresponse and to make the decision of continuing the ongoing therapy or stopping and redirecting the patientto other salvage therapies. Our study also supports the idea of routine use of PET or preferably...

Tài liệu Báo cáo khoa học: Tryptophan tryptophylquinone cofactor biogenesis in the aromatic amine dehydrogenase of Alcaligenes faecalis Cofactor assembly and catalytic properties of recombinant enzyme expressed in Paracoccus denitriﬁcans pptx

... kinetically in uentialionizations were identiﬁed in plots of klim⁄ Kd of pKavalues 7.1 and 9.3,again with the maximum value realized in the alkaline region. The poten-tial origin of these kinetically ... substrate carbinolamine intermediate;III, iminoquinone intermediate; IV, product Schiff base intermediate;V, aminoquinol intermediate. In the oxidative half-reaction the ami-noquinol intermediate ... this represents the ionization of Asp128b. This being the case, the effect of substrate binding would be to lower the pKa of thisgroup to 6.0 (i.e. the value measured in the plot of klimvs....

Báo cáo khoa học: Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability docx

... compromised by the inhibition of PI3K signaling with LY294002 in a fully supplementedmedium and within the tested time period (Fig. 3B, D).QDs induce the formation of LDs in PC12 cells in a growth ... possibility; however, the inhibition of PI3K with LY294002 and the inhibition of FAS with cerulenin caused the disappearance of droplets and prevented the formation of new droplets duringexposure to ... metabolism, resulting in an increase in glucose uptake and an up- regulation of glycolysis[37,38]. In addition, PI3K signaling has been shown tobe involved in the up- regulation of lipogenic enzymes,such...

Báo cáo khoa học: C ﬁ G base mutations in the CArG box of c-fos serum response element alter its bending ﬂexibility Consequences for core-SRF recognition potx

... cm)1correlates with a broadband around 1400 cm)1at 25 °C of about the sameintegral intensity, indicating a larger population of lin-ear conformers. The upshift and increase in intensity of the peak ... SREfos and SREGfos,on the one hand, and SREGGfos, on the other hand,consists in the distinct strains acting on the helix ply of these oligonucleotides. Conversion between the bent and linear ... Indeed, the change in the array of the hydrogen bonds at thymine of SREGGfosis probably a sign of perturbation in the hydration scheme along the minor groove of the (A ⁄ T)domain. The G–C...

Báo cáo khoa học: "PARSING VS. TEXT PROCESSING IN THE ANALYSIS OF DICTIONARY DEFINITIONS" pot

... less than the eight man-months spent developing and testing the LSP definition grammar. Tagging and head finding were performed on a sample of 2157 noun definition texts, covering the nouns ... working on improving the head finder, as well as developing similar "grammars" for posmominal phrases and for the major phrase str~tures of other definition types. In the course of ... already present in the LSP grammar. Figure 1 shows a sample definition and the triples the parser found in it. ABDOMEN 0 1 N THE PART OF THE BODY BETWEEN THE THORAX AND THE PELVIS (THE) pmod...

Báo cáo khoa học: Post-translational modiﬁcations in the active site region of methyl-coenzyme M reductase from methanogenic and methanotrophic archaea potx

... described for the sulfuration of the C-terminal glycine in ThiS and MoaD, involved in thiamine biosynthesis and molyb-dopterin biosynthesis, respectively, and for the sulfura-tion of uridine in tRNA ... methylases[9]. How the sulfur is transferred into the carboxamidegroup of glycine in the peptide chain remains to beshown.Neither the functions of the ﬁve modiﬁcations norwhether the modiﬁcations ... bonds of the protein to the phosphate group of coenzyme B. The distance of 2.65 A˚indicates the presence of a strong hydrogenbond with fully overlapping orbitals. Owing to the positive inductive...

Báo cáo khoa học: Arginine-induced conformational change in the c-ring ⁄a-subunit interface of ATP synthase ppt

... escaping to the cytoplasm. In order to gain insight into the interaction of the stator arginine with the binding site, we modeled astretch of seven amino acids of helix 4 of subunit ainto the ... atoms of the c-ring, with the intention that only the residues of the a subunit and the side chains of the c-ring should be free to move during minimization. Toavoid trapping in local minima, ... calculations for the c-ring and a heptapeptide of helix 4 of sub-unit a. The calculated positions and possiblehydrogen bonds of the binding-site residueson the c-ring and the stator arginine in the presence...

Báo cáo khoa học: Oxidative stress is involved in the permeabilization of the inner membrane of brain mitochondria exposed to hypoxia/reoxygenation and low micromolar Ca2+ Lorenz Schild1 and Georg Reiser2 doc

... thistreatment. The high degree of protection by ADP sug-gests that the mitochondrial injury is caused by open-ing of the mPTP. There is evidence that ADP inhibitsopening of the mPTP by occupying binding ... to the induction of oxidative stress during ischemia ⁄ reperfusion in brain.There is a growing body of information concerning the mechanism of ROS generation by the respiratorychain in mitochondria. ... cyclosporin A. A volume of 2 mL of the incu-bation mixture was centrifuged at 12 000 g for 10 min and the resulting supernatant at 100 000 g for 15 min at 4 °C. Cyto-chrome c was detected in the supernatant...

Báo cáo khoa học: Key substrate recognition residues in the active site of a plant cytochrome P450, CYP73A1 ppt

... mutagenesis of the involve-ment of some of these residues in the docking and catalysis of cinnamic acid. The impact of the active site mutations on the binding and metabolism of cinnamic acid ... affect the binding of cinna-mate and the coupling of the hydroxylation reaction [9].This effect was probably due to a direct interaction of itsside-chain with the aromatic ring of the substrate. ... Mutation of all arginines led to a signiﬁcant loss in protein stabilitysuggesting that they are involved in protein fold structurerather than binding of the substrate. The overall picture of the CYP73A1...

Báo cáo khoa học: Hydrogen bond residue positioning in the 599–611 loop of thimet oligopeptidase is required for substrate selection pdf

... the end of the simulation, despite having a close prox-imity between Tyr hydroxyl groups (e.g. 2–3 A˚) and the substrate in the initial model. In addition to reducing the ﬂexibility of the ... pep-tides, often at the same cleavage site. Rather, the evi-dence in this paper supports a role for the conservedGly residues (599, 603, 604, 611) in the loop, particu-larly Gly603, in maintaining the ... Tyr157 in thermolysin [21,22].His231 (analogous to Tyr612 in TOP) and Tyr157(analogous to Tyr605 in TOP) work together in the Table 2. Percentage of hydrogen bonding distances of the mutants. The...

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