báo cáo khoa học: "CCR9-CCL25 interactions promote cisplatin resistance in breast cancer cell through Akt activation in a PI3K-dependent and FAK-independent fashion" pptx
Báo cáo khoa học: Inhibition of human MDA-MB-231 breast cancer cell invasion by matrix metalloproteinase 3 involves degradation of plasminogen docx
... Hurskainen, T., Hoyta, M., Oikarinen, A. & Autio- Harmainen, H. (1994) 72 kDa and 92 kDa type IV collagenase, type IV collagen and laminin mRNAs in breast cancer: a study by in situ hybridisation. ... plasminogen activation and impair laminin degradation by plasmin. Our data pro- vide evidence that MMP-3 can inhibit breast tumour cell invasion in vitro by a mecha...
Ngày tải lên: 31/03/2014, 09:20
Báo cáo khoa học: Probing the active site of Corynebacterium callunae starch phosphorylase through the characterization of wild-type and His334fiGly mutant enzymes pot
... reported elsewhere [9], and protein was determined by the Bio-Rad (Vienna, Austria) dye binding assay using BSA as standard. Steady-state kinetic analysis and biochemical characterization Initial rates of phosphorolysis ... underlined and the mismatched codons are indicated in bold, respectively: XagI-for, 5¢-GGGAACTCTGCG CCT GTGGAAGGC-3¢; Eco91I-inv, 5¢-CTCATCCAGATCG GTTACCCAATC-3¢;...
Ngày tải lên: 23/03/2014, 07:20
Tài liệu Báo cáo khoa học: Paradoxical interactions between modifiers and elastase-2 Patricia Schenker and Antonio Baici docx
... within the same chain, and also contain sulfate-free sequences. Ch4S from bovine trachea contained 69% 4-sulfate and 25% 6-sulfate; Ch6S contained 45% 4-sulfate and 54% 6-sulfate; DS contained 98% ... endo- peptidases elastase and cathepsin G and of porcine pancreatic elastase by N-oleoyl derivatives of heparin. Biochem Pharmacol 46, 1545–1549. 9 Baici A, Salgam P, Fehr K & Bo...
Ngày tải lên: 16/02/2014, 14:20
Báo cáo khoa học: Differential interactions of decorin and decorin mutants with type I and type VI collagens pptx
... biglycan manifests itself in extremely abnormal architecture of the collagen fibrils. Thus, interactions between the collagens and decorin are of paramount importance in attaining and maintaining tissue ... composed of a core protein and a single covalently linked glycosaminoglycan chain. It b inds to collagen fibrils near the d bands (Ôd ecoratesÕ them) and delays the lateral...
Ngày tải lên: 07/03/2014, 16:20
Báo cáo khoa học: Netropsin interactions in the minor groove of d(GGCCAATTGG) studied by a combination of resolution enhancement and ab initio calculations pot
... geometry based on HF ⁄ 6–31G* calculations of the interaction between (A) the amidinium end and bases A2 5, T8 and G9; and (B) the guanidinium end and bases A5 , T28 and A6 . Intermolecular geometry ... & Spackova N (2000) Local conformational variations observed in B-DNA crystals do not improve base stacking. Computational analysis of base stacking in d(CATGGGCCCATG) 2 B...
Ngày tải lên: 16/03/2014, 22:20
Báo cáo khoa học: Protein interactions in the sumoylation cascade – lessons from X-ray structures pdf
... motif (Fig. 6B, amino acids 469– 486). At present, no structural data are available for the ubc9-binding and substrate interaction regions. A separate domain in the N-terminal domain has been reported ... (SIM) and a C-terminal domain (CTD) [39]. (B) Pc2 contains an uncharacterized E3 domain, a ubc9 binding domain and a Pro-Ile-Asp-Leu-Ser motif involved in substrate binding...
Ngày tải lên: 30/03/2014, 04:20
Báo cáo khoa học: Tracking interactions that stabilize the dimer structure of starch phosphorylase from Corynebacterium callunae Roles of Arg234 and Arg242 revealed by sequence analysis and site-directed mutagenesis doc
... The data also reveal that the replacement of the guanidinium side chain of arginine by a methyl side chain of alanine in the R23 4A and R24 2A mutants caused only a small effect on the binding of ... two asparagines of rmGP is replaced positionally by a glutamate in StP. Considerations of charge and packing arrangements suggest that if Arg234 and Arg242 were truly involved...
Ngày tải lên: 31/03/2014, 01:20
Báo cáo khoa học: Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis docx
... apoptotic cascade by nonoxidant agonists may involve early release of lysosomal constituents (such as cathepsins B and D) and activation of PLA2, leading to enhanced mitochondrial oxidant production, ... Marceau, F. & Landry, J. (1997) Oxidative stress-induced actin reorganization mediated by the p38 mitogen- activated protein kinase/heat shock protein 27 pathway in vas- cular end...
Ngày tải lên: 31/03/2014, 07:20
Tài liệu Báo cáo khoa học: Molecular basis of glyphosate resistance – different approaches through protein engineering doc
... Glypho- sate and D-AP3 have the same chemical composition and key recognition groups, but D-AP3 is a branched primary amine, whereas glyphosate is a secondary amine with a linear structure and a greater ... the shikimate pathway leading to the synthesis of aromatic amino acids and other aromatic compounds in plants, fungi, bacteria [9], and apicomplexan parasites [10]. The...
Ngày tải lên: 14/02/2014, 14:20
Tài liệu Báo cáo khoa học: Homologous expression of the nrdF gene of Corynebacterium ammoniagenes strain ATCC 6872 generates a manganese-metallocofactor (R2F) and a stable tyrosyl radical (Y•) involved in ribonucleotide reduction ppt
... (5¢-TTT TTC TAG AGC AGG GTA GGT TGA TTT CAT GTC GAA TG-3¢; additional XbaI site underlined) and OB 3 (5¢-AAA AGA ATT CTT AGA AGT CCC AGT CAT CGT C-3¢; additional EcoRI site underlined). The amplified ... nrdF + gene was sequenced by a primer walking approach. For DNA analysis, dnastar software (DNAS- TAR Inc., Madison, WI, USA) and clone manager 5.0 (Scientific & Educational Software,...
Ngày tải lên: 15/02/2014, 01:20