báo cáo khoa học: "Chemoradiotherapy followed by surgery versus surgery alone in esophageal cancer patients: is it time for additional evidence?" doc

... followed by surgery versus surgery alone in esophageal cancer patients: is it time for additional evidence? Stefano Cafarotti 1* , Alfredo Cesario 1,2 , Venanzio Porziella 1 , Stefano Margaritora 1 and ... IIa-III esophageal carcinoma is still unresolved. Findings We have read with interest the report from Hurmuzlu and coll [1] on the outcome of induction the...

Ngày tải lên: 09/08/2014, 01:24

... 2-140 months) after initial treatment of patients with breast cancer via regular visit (annually) for discovering the LRR. In addition to routine clinical examination, disease assessment included mammography, ... diagnosed with breast cancer and have completed initial treatments remain at risk for recurrent cancer [2,3]. Surgery com- bined with radiotherapy has been the typical...

Ngày tải lên: 09/08/2014, 03:21

... these domains. This is in line with our results where the variant in exon 11 found associated with breast cancer risk is also not located in any of these domains. In a recently reported in vitro study ... used in Additional file 1). Below is given an illustration of the pro- tein with important areas such as substrate binding domains, Leucine zipper, ATP-binding domains,...

Ngày tải lên: 09/08/2014, 10:21

... advanced- stage disease at presentation. In our institution in the period analyzed (1985–2000), IFRT was defined as treatment volume including the ini- tially involved lymph node region(s) and 82.4% of initial clinical ... Rudolph C, Reiser M: Time – intensified dexametha- sone/cisplatin/cytarabine: An effective salvage therapy with low toxicity in patients with relapsed and refractor...

Ngày tải lên: 09/08/2014, 10:21

... equili- brated with 50 m M potassium phosphate, pH 4, containing 8% (v/v) acetonitrile for 15 min and then developed with a linear gradient of 8–40% acetonitrile in the same buffer for 5min.The flowratewas ... facilita- ted by the contiguous 13 C labeling of the metabolites. Moreover, this experimental approach minimizes the risk of artefact formation by decomposition of chemically u...

Ngày tải lên: 23/03/2014, 18:20

... this increase was significantly inhibited by 10 μM DCQ (Fig- ure 2B). This is in contrast to the observed increase in HIF-1a in response to 5 μMor10μM DCQ under nor- moxia in this cell line. In ... angi oge nesis [22-24]. This renders cancer cells bet- terabletosurviveintheharshhypoxicconditions[25]. Therefore, inhibiting HIF-1a-mediated signaling is important for enhancin...

Ngày tải lên: 09/08/2014, 09:20

... the early apoptosis was calcu- lated by annexin V-positivity and PI-negativity, while the percentage of the late apoptosis was calculated by annexin V-positivity and PI-positivity. Fluorescent ... proliferation inhibition a nd apoptosis in cancer cells [24,25]. During cell cycle, the G2/M checkpoint is a potential target for c ancer ther- apy. It prevents DNA-damaged cells from...

Ngày tải lên: 10/08/2014, 10:21

... for gastrointestinal epithelial tissue. Involved in G-protein signalling 24.3 Diacylglycerol kinase, epsilon (64 kDa) May be involved mainly in the regeneration of phosphatidylinositol (PI) from ... (IL-20RA) Receptor for interleukin 20 (IL-20), a cytokine that may be involved in epidermal function. 24.6 Peptidyl-prolyl cistrans isomerase NIMA-interacting 1-like (PIN1L) May be invol...

Ngày tải lên: 19/02/2014, 07:20

... sequence identity of 30–45%), this position is occupied solely by a valine. This conserved amino acid is replaced by isoleucine in the Val371Ile FXI mutant. Interestingly, an isoleucine residue ... amino acids (the b-carbon has two substitutions); nev- ertheless, the mutation is not isosteric, isoleucine being larger than valine, and having an additional methyl on its side chain...

Ngày tải lên: 23/03/2014, 07:20

... glu- cose-enriched medium. During ubiquitination, up to six molecules of ubiquitin (8.5 kDa) can be added to form a polyubiquitin chain. We performed the experi- ments by immunoprecipitating Grx2 from the ... deglutathionylation by Grx2 (evaluated by anti-GSH blotting analysis) in the pres- ence of cardiolipin was greatly enhanced (Fig. 6C). It is noteworthy that, with increasing...

Ngày tải lên: 23/03/2014, 07:20