Báo cáo y học: "Oxidation in rheumatoid arthritis" docx

... homology to other HA-binding link proteins. The two basic clusters (gray segments in Fig. 1A, inset a) are involved in HA binding: the first (located inside the link module and overlapping the ... to HA binding are also shown in Fig. 1A, inset a. Cys-266 in the transmembrane domain (Fig. 1A, inset b) is important for HA binding in Jurkat cells. Cys-266 and Cys-275 can be used for pa...

Ngày tải lên: 09/08/2014, 01:21

... consequence of the activation of many cell populations and, ultimately, of the upregulation of proinflammatory cyto- kines [19,20]. By whichever means they themselves become activated, they induce ... activity. The degree of disease activity at the start of a disease-modifying therapy is a major determinant of the disease activity attainable in treatment. Background...

Ngày tải lên: 09/08/2014, 01:22

... proliferate. Susceptibility of rheumatoid arthritis synovial fibroblasts to FasL- and TRAIL-induced apoptosis Next, we analysed the cell cycle dependency of FasL- and TRAIL-induced programmed cell death of RASFs ... of tumour necrosis factor-related apoptosis- inducing ligand (TRAIL) receptors on rheumatoid arthritis synovial fibroblasts (RASFs)Surface exp...

Ngày tải lên: 09/08/2014, 01:22

... cause proteins to become non-enzymatically damaged by glyoxidation. This process, which involves primarily lysine and arginine residues, ultimately results in the generation of advanced glycation ... hyaluronan and chondroitin sulfate [39,40] and damage the hyaluronan- binding region of the proteoglycan core protein, thereby interfering with proteoglycan–hyaluronan interactions [41]. In a...

Ngày tải lên: 09/08/2014, 01:24

... [6]. Histopathologic evaluation of synovial tissue shows chronic changes shortly after the onset of symptoms, and the cytokine profile in early disease as determined by immunohistochemistry is nearly ... preclinical phase. Commentary Pathogenesis of rheumatoid arthritis: how early is early? Gary S Firestein Division of Rheumatology, Allergy and Immunology, UCSD Schoo...

Ngày tải lên: 09/08/2014, 06:23

... 6 Research article Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis John R Glossop, ... associated with a protective role in familial RA [30]. In this study we report that polymorphism in the TNF-RII gene, but not the TN...

Ngày tải lên: 09/08/2014, 07:20

... and DA were involved in designing the study, analyzing the data, and drafting the manuscript. TS, KPM and KM were involvement in data acquisition. References 1. Graudal NA, Jurik AG, de Carvalho ... monitoring, comedication and even the increasingly employed paradigm to change therapy if a state of low disease activity is not reached within few months [16,17] – re-prescribing meth...

Ngày tải lên: 09/08/2014, 07:20

... 2 Research article Variability in synovial inflammation in rheumatoid arthritis investigated by microarray technology Johan Lindberg 1 , Erik af Klint 2 , Ann-Kristin Ulfgren 2 , André Stark 3 , ... with rheumatoid arthritis. This was done by applying microarray technology on multiple synovial biopsies obtained from the same knee joints. In this way the relative l...

Ngày tải lên: 09/08/2014, 07:20

... synovial lining layer in ND and more to the sublining layer in RA and OA patients (Figures 4 and 5) . Figure 2 Expression of BMP -4 and BMP -5 in synovial tissues detected by microarray techniqueExpression ... samples of our RA and OA patients may influence predominantly cells of the sur- rounding tissue, thereby contributing to synovial fibrosis. In...

Ngày tải lên: 09/08/2014, 07:20

... initially present in the small joints of the feet, and appear in the small joints of the hands at a later point in the disease course [6]. Also, rheumatoid nodules are very rare in the early phases of RA, ... evaluated. Review Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets Anne...

Ngày tải lên: 09/08/2014, 10:23

... in < /b> increased numbers in < /b> patients with RA [19]. As a result, post-switch memory < /b> B cells accumulate not only in < /b> the synovium but also in < /b> the blood < /b> of patients with long-standing RA. The human memory < /b> ... article Alterations in < /b> peripheral < /b> blood < /b> memory < /b> B cells in < /b> patients with active...

Ngày tải lên: 09/08/2014, 14:21

... to a synthetic blockade of the second step of the enzyme P450c17, again induced by inflammatory cytokines such as IL1β and TNF. Increased DHEAS levels during treatment with TNF antagonists in active ... anti-inflammatory activities, are significantly decreased in inflamed tissues (that is, synovial fluid) during active RA in both male and female patients, which supports a pro-inflamma...

Ngày tải lên: 09/08/2014, 14:22

... origin as Lin − /7-aminoactinomycin D (7AAD) − / CD34 + /CD133 + /VEGFR-2 + cells and the number of these cells was indeed higher in RA patients compared with controls. In addition, the colony-forming ... late-outgrowth EPCs of solely heman gioblastic origin may be involved in vascular repair. As this EPC subset may be preferentially involved in the active stage of the disease, i...

Ngày tải lên: 12/08/2014, 11:23

... distribution, and reproduction in any medium, provided the original work is properly cited. Research article Remission in psoriatic arthritis: is it possible and how can it be predicted? Tajvur P Saber 1,2 , ... 10.1186/ar3021 Cite this article as: Saber et al., Remission in psoriatic arthritis: is it possible and how can it be predicted? Arth...

Ngày tải lên: 12/08/2014, 14:21

... antirheumatic drugs included in the study Abatacept Adalimumab Anakinra Azathioprine Cyclosporin D-penicillamine Etanercept Gold Hydroxychloroquine Infliximab Leflunomide Methotrexate Minocycline Rituximab Sulfasalazine Table ... Health care utilization databases have been increasingly used for studies of rheumatoid arthritis (RA). However, the accuracy of RA diagnoses in...

Ngày tải lên: 12/08/2014, 15:22