Báo cáo y học: "Mast cells in inflammatory arthritis" pdf

... C-reactive protein levelsChanges in disease activity in 30 patients with rheumatoid arthritis at different times during 78 weeks of infliximab therapy as determined by (a) Disease Activity Score (DAS ... Arnoldi C: Drug-induced lupus following treatment with infliximab in rheumatoid arthritis. Lupus 2002, 11:753-755. 32. Ali Y, Shah S: Infliximab- induced systemic lupus...

Ngày tải lên: 09/08/2014, 01:23

... of ANA and anti-dsDNA autoantibodies and demonstrated that the induction of ANA, anti-dsDNA and aPL autoantibodies is related to infliximab treatment in both RA and AS, with no significant relationship ... 1- year intervals. ANA, anti-dsDNA and aPL were the only autoantibodies to be significantly induced by infliximab treatment in RA and AS patients. This induction has a...

Ngày tải lên: 09/08/2014, 01:24

... selectins and integrins on synovial endothelium, allowing migration up chemotactic gradients into the joint. The composition of inflammatory cells recruited in a continuing fashion by mast cells, including ... within the inflamed synovium. Equipped with an impressive array of mediators, mast cells can promote synovitis by recruiting inflammatory cells from the blood, inducing syn...

Ngày tải lên: 09/08/2014, 01:24

... important in retaining the cells at this site [17,18]. In about 20% of patients with RA, infiltrating T and B lym- phocytes accumulate underneath the synovial lining layer and organize into lymphocyte ... The induction of BCA-1 and other lymphoid-tissue-inducing chemokines may convert the synovial lesion from an acute to a chronic state by amplifying antigen-specific responses. Blocking...

Ngày tải lên: 09/08/2014, 03:24

... rheumatoid factor; SE = HLA DRB1 shared epitope. Available online http:/ /arthritis- research.com/4/4/R1 Research article B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared ... lymphocytes is plotted on the x axis, and the number of patients in each frequency range is plotted on the y axis. The overlays represent the Ga...

Ngày tải lên: 09/08/2014, 03:24

... RANK/ RANKL in inflammatory cells, in inflamed synovium, in artic- ular cartilage and at the invading front of bone erosions. It has been long recognized that pro -inflammatory cytokines are intimately ... online http:/ /arthritis- research.com/content/7/1/R57 R57 Vol 7 No 1 Research article A model of inflammatory arthritis highlights a role for oncostatin M...

Ngày tải lên: 09/08/2014, 06:22

... inflammatory arthritis. Interestingly, c-Fos overexpression in α v β 3 -deficient osteoclasts substantially rescues the cells’ capacity to organize their cytoskeleton [28]. In contrast, the integrin ... bone in an inflammatory environment has provided new therapeutic targets that are now being assessed in clinical trials. Competing interests The author(s) declare that they have no...

Ngày tải lên: 09/08/2014, 07:20

... T and B lymphocytes are involved and Review B cells in Sjögren’s syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue Arne Hansen 1 , Peter E Lipsky 2 and ... homing of B cells to lymphoid follicles and in the development of organized lymphoid follicles in healthy individuals [60]. Mice deficient in the lym...

Ngày tải lên: 09/08/2014, 10:20

... treatment in the inflammatory rheumatic diseases nowadays has become reaching and sustaining remission. Clinical remission, meaning absence of clinically visible disease manifestations, including the ... Heijde D, Bellamy N, Calin A, Dougados M, Khan MA, van der Linden S: Assessments in Ankylosing Spondylitis Working Group. Preliminary core sets for endpoints in ankylosing spondylit...

Ngày tải lên: 09/08/2014, 14:22

... [53,55] in myeloid cells suggests that BAFF may act as a kind of secondary cytokine translating mainly IFN and TNF effects. An important immunoregulatory cytokine produced by B cells is IL-10, ... number of recent findings. First, findings in both humans and mice have indicated an essential role for this cytokine in co-stimulating B cells to differentiate into plasma cells [29]....

Ngày tải lên: 09/08/2014, 14:22

... citation purposes) Journal of Immune Based Therapies and Vaccines Open Access Review Dendritic cells: In the forefront of immunopathogenesis and vaccine development – A review Mansour Mohamadzadeh* 1 ... bacteria including Lactobacillus. Lactoba- cillus will be orally administrated. These bacteria colonize the gut and express and release the immunogen in...

Ngày tải lên: 11/08/2014, 10:23

... Open Access B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcgRIIb, which are modulated by anti-tumor necrosis factor therapy Diego Catalán 1 , ... coordination of the study. AMK participated in the conception and design of the study and critically revised the manuscript. JCA par...

Ngày tải lên: 12/08/2014, 12:20

... inflammatory rheumatic diseases [1-5]. An adaptational stress response involves the activation of both the hypothalamus-pituitary-adrenal axis (HPA axis) [6] and the autonomic nervous system (ANS) ... stressors in rheumatic populations [2]. Studies investigating stressors in daily life reported an association between stressors, mainly of an interpersonal nature, and concentrat...

Ngày tải lên: 12/08/2014, 12:20

... soon. Mast cells are the main interleukin-17-positive cells in anti-citrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium Arthritis Research & Therapy ... mast cells were also activated by citrullinated proteins present in the joint, thereby releasing IL-17 that contributes to the inflammatory m...

Ngày tải lên: 12/08/2014, 18:20

... transferred into an oocyte or fused with an ES cell, the underlying mechanisms remain obscure. Using the ES fusion system, Smith has found an unexpected role for the homeo- domain-containing protein Nanog ... model system than mice in certain fields, particularly neuroscience, and progress has been greatly hampered by our inability to derive rat ES cells. Shinohara hinted that he was...

Ngày tải lên: 14/08/2014, 16:21