... changes of TRAIL by acidification provide anexplanation for intrinsic properties of TRAIL toward themembrane, as observed in such structurally and evolutio-narily related cytokines as TNF -a and ... Malis-zewski,C.R.&Fanger,N .A. (1999)Monocyte-mediatedtumor-icidal activity via the tumor necrosis factor-related cytokine, TRAIL. J. Exp. Med. 189, 134 3–1 354.7. Kayagaki, N., Yamaguchi, N., Nakayama, M., Kawasaki, A. ,Akiba,H.,Okuma,K.&Yagita,H.(1999)InvolvementofTNF-related ... and PtdSer at acidic pH values. In many cases, the binding of a protein with lipid bilayer disrupts the bilayer integrity tomake the membranes permeable [30,31]. To ascertainwhether TRAIL alters...