Báo cáo y học: "Apolipoprotein A-I infiltration in rheumatoid arthritis synovial tissue: a control mechanism of cytokine production" pot

... inhibition of TNF-α and IL-1β production. This study examined the hypothesis that apoA-I may have a regulatory role at sites of macrophage activation by T lymphocytes in inflamed RA synovial tissue. Synovial ... pathogenesis and the maintenance of chronic inflammation in diseases such as RA. Regulating a potent mechanism that induces both IL- 1β and TNF-α may be important...

Ngày tải lên: 09/08/2014, 01:24

... study and after 12 and 24 months, using vaginal ultrasonography and cytology. E 2 in serum was measured (approximately 12 hours after tablet intake) by radioimmunoassay (Clinical AssaysTM, DiaSorin, ... 2:1132-1136. 16. Kameda T, Mano H, Yuasa T, Mori Y, Miyazawa K, Shiokawa M, Nakamaru Y, Hiroi E, Hiura K, Kameda A, Yang NN, Hakeda Y, Kumegawa M: Estrogen inhibits bone resorption by d...

Ngày tải lên: 09/08/2014, 01:21

... (d- CAC CTC TGG GCT ACG TGC TAG) and R (d-GAA CAC ATG CTG AGG TTT AAA GAG AAT); and glyceral- dehyde-3-phosphate dehydrogenase primers were F (D- AAC AGC GAC ACC CAT CCT C) and R (d-CAT ACC AGG AAA ... S, Yamamura M, Okamoto H, Morita Y, Kawashima M, Aita T, Makino H: Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritis....

Ngày tải lên: 09/08/2014, 06:22

... treatment of RA remains an area of considerable challenge. Therapeutic approaches in the past several decades have included corticosteroids, methotrexate, sulfasalazine, cyclophosphamid, cyclosporine, ... elevated levels of cytokines, including pro-inflammatory cytokines such as IL-1, TNF-α, and IL-6 and a large range of others [5]. The evidence in support of an immune basis h...

Ngày tải lên: 09/08/2014, 06:22

... regulatory function in vivo, despite their enhanced regulatory capacity in vitro. Although it is tempting to speculate that synovial inflammation is the consequence of an inadequate ability of synovial ... synovial Tregs to downmodulate local inflammation, several observations indicate clearly that synovial Tregs are functional and actively dampen the inflammatory immune respo...

Ngày tải lên: 09/08/2014, 06:22

... measurement of a product of the process resulting in joint damage may be of value in predicting such an outcome. A number of assays have recently become available to measure the degradation and repair of ... Demographic and clinical characteristics of these patients 1 year after diagnosis are summarized in Table 1. The mean age was 58 years, and 63% of the participants...

Ngày tải lên: 09/08/2014, 07:20

... ultrasonography and MRI in fourth proximal inter-phalangeal joint: early RASigns of synovitis on ultrasonography and MRI in fourth proximal inter- phalangeal joint: early RA. Arrows indicate an area ... development and preliminary data interpre- tation. HST and MØ took part in the study development and gave substantial input into data evaluation and manuscript preparation. All authors...

Ngày tải lên: 09/08/2014, 07:20

... capable of promoting inflammation by inducing a variety of pro-inflammatory media- tors, including cytokines, chemokines and other mediators of bone and cartilage destruction in synovial fibroblasts, ... rheumatoid arthritis (RA) synovial fluid (SF) and to determine the level of interleukin (IL)- 17 cytokine in RA, osteoarthritis (OA) and normal synovial tissue, as w...

Ngày tải lên: 09/08/2014, 10:23

... shaver biopsy, and cDNA was analyzed by quantitative real-time polymerase chain reaction (a, b). Extracts were analyzed by enzyme-linked immuno- sorbent assay for antibodies of interest and albumin ... arthritis (RA) syno-via is associated with elevated synovial autoantibody levelsThe presence of lymphoid aggregates in rheumatoid arthritis (RA) syno- via is associated with ele...

Ngày tải lên: 09/08/2014, 13:21

... plaque and rheumatoid synovium share an array of inflammatory cells and cytokines [14], suggesting that chronic rheumatoid inflam- mation may contribute to excess atherosclerosis in RA. In addi- tion, ... attenuated to varying degrees in models including IL-6, a marker of system inflammation – suggesting that IL-6 is a potential mediating variable. Increasing overall RA seve...

Ngày tải lên: 09/08/2014, 13:22