Báo cáo y học: "Ethics of randomised controlled trials – not yet time to give up on equipoise Richard E Ashcroft" pps

... this? Commentary Ethics of randomised controlled trials – not yet time to give up on equipoise Richard E Ashcroft Medical Ethics Unit, Imperial College London, London, UK Corresponding author: Richard E Ashcroft, ... the ‘positive expected value’ test [1]. The concept of equipoise has been introduced into the medical literature on many occasions [ 2–...

Ngày tải lên: 09/08/2014, 01:24

... greater than the placebo group. None of the treatment groups exhibited changes in heart rate or blood pressure relative to the control group, nor there were no differences in self-reported ... randomized placebo -controlled double-blinded study design, the absence of thermogenic changes in the placebo group, the absence of adverse effects on blood pressure, heart-rate and se...

Ngày tải lên: 25/10/2012, 11:04

... molecular chaperones, but the effects of these interactions on the maturation of these receptors have not yet been determined. In the present study, it was established that interactions between ... 50% of the receptors, which were not able to enter the maturation pathway were certainly degraded by the proteasome after being retanslocated into the cytosol (Fig. 2). Similar resu...

Ngày tải lên: 31/03/2014, 08:20

... Insurance (Caisse National d’Assurance Maladie) set up a “Health Center” (“Centre de Sante”) to promote prevention and screening of diseases. Once every 5 years, these centers sent invitations to ... included con- secutive clients (both women and men) over the legal age of 18 who agreed to participate in the survey. Subjects were given a written description of the survey...

Ngày tải lên: 08/08/2014, 17:20

... significant effect in the subjects' degree of presence experienced in the VR condition about their level of perceived anxiety (STAI-S and VAS-A): the higher the sense of presence, the stronger the ... hypothesis, we found an effect of subjects' degree of presence experienced in the VR condi- tion on their level of perceived anxiety (STAI-S and VAS- A): the higher the...

Ngày tải lên: 08/08/2014, 23:21

... acid decarboxylase, T cells were tested for responses to peptide after separation with I-A g7 /peptide multimers [8]. Essentially all of the reactive clones appeared to be present in the multimer-positive pool. ... zipper to compensate for the missing hydrophobic transmembrane regions [14]. The peptide can then be added to the secreted soluble mole- cules, prior to multimerization...

Ngày tải lên: 09/08/2014, 03:24

... nature and extent of function of this carboxypeptidase are yet to be determined. A polymorphism in this gene would potentially affect the function of any of the peptides cleaved by this enzyme and ... and Behçet's disease is not significant after correction for multiple testing. We next determined the genotype frequency differences between patients with Behçet's diseas...

Ngày tải lên: 09/08/2014, 14:20

... 0.009 Diabetes mellitus 4.8 1.8-12.9 0.002 4.5 1.4-15.2 0.014 a In multivariate analyses, the following variables were used: gender, age, prednisolone only, methotrexate only, sulfasalazine only, hydroxychloroquine ... Research & Therapy Vol 11 No 5 Raterman et al. Page 2 of 2 (page number not for citation purposes) Table 1 Characteristics of the study population MetS present a MetS...

Ngày tải lên: 09/08/2014, 14:22

... Research & Therapy Vol 11 No 5 Toms et al. Page 2 of 2 (page number not for citation purposes) Competing interests The authors declare that they have no competing interests. Acknowledgements This ... is supported by a PhD scholarship from the Empirikion Institute, Athens, Greece. References 1. Toms TE, Panoulas VF, Douglas KMJ, Kitas GD: Methotrexate therapy associates with a reduced...

Ngày tải lên: 09/08/2014, 14:22

... important to examine the ESE and ESS changes with the age of duplication. We use the Ka between duplicates as a proxy of duplication age. Compared to mouse, the ESE changes are negatively correlated ... converted into their reverse and complementary sequences, and original ESE sequences were purged from the converted sequences. The end result was 327 real ESE and 327 control ESE motif...

Ngày tải lên: 09/08/2014, 20:20