Báo cáo y học: "Infliximab therapy in rheumatoid arthritis and ankylosing spondylitis-induced specific antinuclear and antiphospholipid autoantibodies without autoimmune clinical manifestations: a two-year prospective study" potx
Báo cáo y học: "Infliximab therapy in rheumatoid arthritis and ankylosing spondylitis-induced specific antinuclear and antiphospholipid autoantibodies without autoimmune clinical manifestations: a two-year prospective study" potx
... of ANA and anti-dsDNA autoantibodies and demonstrated that the inductionof ANA, anti-dsDNA and aPL autoantibodies is related toinfliximab treatment in both RA and AS, with no significantrelationship ... 1-year intervals.ANA, anti-dsDNA and aPL were the only autoantibodies tobe significantly induced by infliximab treatment in RA and AS patients. This induction has already been described forANA and ... ankylosing spondylitis-induced specific antinuclear and antiphospholipid autoantibodies without autoimmune clinical manifestations: a two-year prospective studyCarole Ferraro-Peyret1, Fabienne...
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Báo cáo y học: " Autoantibody profile in rheumatoid arthritis during long-term infliximab treatment" pdf
... Anticitrullinatedprotein/peptide antibody assays in early rheumatoid arthritis for predicting five years radiographic damage. Ann Rheum Dis2003, 62:120-126.19. Bas S, Genevay S, Meyer O, Gabay C: Anti-cyclic citrullinatedpeptide ... 48:1165-1166.Available online http:/ /arthritis- research.com/content/6/3/R264R268Autoantibody associated clinical manifestations A 34-year-old woman developed malar rash and a mild arthritis flare along ... rabbit antihuman IgG (heavy and light chains) or polyclonal rabbit antihuman IgM (heavy and light chains) according to the manufacturer's instruc-tions. The absorbance was read at 450 nm....
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Báo cáo y học: "Sinus aspergilloma in rheumatoid arthritis before or during tumor necrosis factor-alpha antagonist therapy" ppsx
... surgery and 109 myceto-mas of paranasal sinuses. Laryngoscope 1997, 107:112-117.28. Dahniya MH, Makkar R, Grexa E, Cherian J, al-Marzouk N, MattarM, Saghir E, Fathi al-Samman T: Appearances ... anemia, osteopeniaGlucocorticoid therapy, methotrexate, salazopyrine Yes a Rheumatoid arthritis (RA) duration at aspergilloma diagnosis.Table 2Previous otorhinolaryngological disease and aspergilloma ... Rosa FG, Shaz D, Campagna AC, Dellaripa PE, Khettry U, Cra-ven DE: Invasive pulmonary aspergillosis soon after therapy with infliximab, a tumor necrosis factor-alpha-neutralizingantibody: a...
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Báo cáo y học: "Homing chemokines in rheumatoid arthritis" doc
... with RA, infiltrating T and B lym-phocytes accumulate underneath the synovial lining layer and organize into lymphocyte aggregates with germinalcentres (GCs) [19–21]. These ectopic lymphoid ... macrophage inflammatory protein-1α (MIP-1α or CCL3) in RA synovial tissue, and that elevatedlevels of these chemokines are also detected in RA syn-ovial fluids [9]. IL-8 and ENA-78, which act ... detected in all instances whereextranodal lymphoid structures were examined, includingH. pylori-induced, gastric-mucosa-associated lymphoidtissue and gastric lymphomas [34] as well as Sjögren’ssyndrome...
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Báo cáo y học: "B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response" docx
... Detailed clinical and labo-ratory data, and serial radiographs of hands and feet wereavailable for all patients (see Table 1).Serum and whole blood samples were obtained from eachpatient. Laboratory ... e-mail: haentzho@medizin.uni-leipzig.deSupplementary materialSupplementary Materials and methodsSerum concentrations of RF IgM and IgA were determinedusing a standard ELISA assay (Autozyme™ ... jointdestruction was determined on the last available radio-graph of the hands. As a parameter applicable to theadvanced stage of joint destruction present in the majorityof cases, radiographs were analyzed...
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Báo cáo y học: "Myocardial dysfunction in rheumatoid arthritis: epidemiology and pathogenesis" pps
... eventuallyclinically recognizable ventricular dysfunction (Fig. 1).Inflammatory pathways and myocardial remodelingThe process by which cardiac structure and function adaptsto physiologic changes ... ‘myocardial remodeling’ and involves the cellular and interstitial changes leading tomyocyte hypertrophy, ventricular dilatation, alterations in interstitial collagen superstructure, and interstitial ... and prospective, population-based [40] studies, and may beincreased in RA [44,45]Valvular heart diseaseHemodynamically significant cardiac valvular disease maylead to overt CHF through maladaptive...
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Báo cáo y học: "Bone erosions in rheumatoid arthritis can be repaired through reduction in disease activity with conventional disease-modifying antirheumatic drugs." pot
... Akiko Senuma2 and Yoshiaki Ishigatsubo31Intractable Disease Center, Yokohama City University Medical Center, Yokohama, Japan2Department of Rheumatology, Yokohama Minami Kyousai Hospital, ... Kyousai Hospital, Yokohama, Japan3Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, JapanCorresponding author: Haruko Ideguchi, ... difficult to define repair clearly.Third, there is an interval between clinical findings and corre-sponding radiographic phenomena in clinical trials, and most clinical trials have insufficient...
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Báo cáo y học: "Biological therapy in early arthritis – overtreatment or the way to go" pptx
... of infection and malignancy.Introduction Rheumatoid arthritis (RA) is a progressive destructiveinflammatory disease associated with pain and disability. Ithas a significant negative impact ... infliximabgroups. More patients receiving infliximab had clinicallyReviewAspects of early arthritis Biological therapy in early arthritis – overtreatment or the way to go?Kei Ikeda, Sally ... persistentdisease and structural damage in early arthritis; these includedisease duration, disease -specific autoantibodies (rheumatoid factor and anti-CCP antibody) and erosions on radiograph[55]....
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Báo cáo y học: "Epigenetic modifications in rheumatoid arthritis" pptx
... skin fibrosis. Arthritis Rheum 2007, 56:2755-2764.21. Nasu Y, Nishida K, Miyazawa S, Komiyama T, Kadota Y, Abe N,Yoshida A, Hirohata S, Ohtsuka A, Ozaki T: Trichostatin A, a histone deacetylase ... process is mainly catalyzed by two main RNAseIII-type endonucleases of which Drosha acts in the nucleuswhereas Dicer acts in the cytoplasm. Mature miRNAs that areincorporated into the RNA-induced ... factor-kappa-B; OA = osteoarthritis; PBA = phenylbutyrate; RA = rheumatoid arthritis; RASF = rheumatoid arthritis syn-ovial fibroblast; RISC = RNA-induced silencing complex; RNA-Poly II = RNA...
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Báo cáo y học: "Rituximab treatment in rheumatoid arthritis: how does it work" pdf
... work?Maria JH Boumans and Paul P TakDivision of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, 1100 DE Amsterdam, the NetherlandsCorresponding author: Paul ... cells in the pathogenesis of RA hadpreviously been suggested by the association with auto-antibodies (rheumatoid factor and anti-citrullinated proteinantibodies), which can be found already in ... not exhibit a clinical response. The paper by Nakou and colleagues suggeststhat a decrease in CD19+CD27+ memory B cells in bothperipheral blood and bone marrow precedes the clinical responseto...
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