... profiles in the syn-ovial lining tissues in situ in early RA using synovial specimensobtained by targeted biopsy, followed by LCM and cDNAmicroarray analyses. Based on cluster analysis, we found atleast ... rheumatoid arthritis using targeted biopsy specimensTakahito Tsubaki1, Norimasa Arita1, Takuma Kawakami2, Takayuki Shiratsuchi2, Haruyasu Yamamoto1, Nobuo Takubo3, Kazuhito Yamada3, ... synovial cells, typical palisading ofsynovial cells in the intimal lining layers, non-foreign-body-typegiant cells in the lining regions, lymphoid and plasma cell infil-tration, neovascularization,...