Báo cáo y học: " Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients" pdf

... meet the variable demands imposed by the intermittent course of RA. Evidence from animal models convincingly supports the application of gene therapy in RA, and the feasibility of gene therapy was ... synovial lining layer in both arthritis models. An alternative approach for suicide gene therapy is to inhibit cell proliferation. The cell cycle is contro...

Ngày tải lên: 09/08/2014, 01:24

... to dealing with the range of autoantigens that might be pathogenic in RA and MS by array technology. They used 253 antigens for their synovial array and 406 for their myelin array. This, of course, ... further control not examined was the testing of the CII immunised mice on the myelin array or vice versa. A controversial finding in this study was the demonstration of...

Ngày tải lên: 09/08/2014, 13:22

... ideal for human germline gene therapy. A major problem is the relatively low rate of transgene integration: in mice, the overall efficiency of transgenesis (taking into account embryo loss in ... purpose of this paper is to consider the potential for applying the available genetic modification (GM) technologies to the goal of achieving human germline gene th...

Ngày tải lên: 03/11/2012, 10:01

... met by responsible gene therapy protocols using safe vectors. Two clinical trials exploring the use of gene therapy in OA are under way and another is in the pipeline. If successful, they could ... arthritis gene therapy in the refereed literature. The data are based on a PubMed search using ‘arthritis gene therapy as the search term. The first paper on...

Ngày tải lên: 09/08/2014, 01:22

... and gener- ally reduced the signs of inflammation. The groundwork for further studies on the dynamics of lymphocyte interactions in the synovium has thus been established. Most of the work in intravital ... leukocyte and lymphocyte migration in the parenchyma of tissues can be followed in vivo by imaging in thin tissues like the mesen- teries or by fluorescen...

Ngày tải lên: 09/08/2014, 01:22

... complement- dependent cellular cytotoxicity of the cells expressing the cytokine [37]. Furthermore, infliximab has been shown to increase the number of apoptotic T lymphocytes in the lam- ina propria [38] and ... and clinical statuses are pre- sented in Table 1. Patients were followed clinically by the same physician during this period at regular intervals and in particu...

Ngày tải lên: 09/08/2014, 01:24

... PTPN12, are found among lists of genes that are directly regulated by the TNFα/NFκB pathway, whether in RA [41] or in another context [42,43]. Therefore, it is likely that most of our transcripts are ... and detailed in Table 4. The identity of the corre- sponding microarray cDNA probes was verified by sequenc- ing. Finally, we performed an unsupervised hierarchical...

Ngày tải lên: 09/08/2014, 08:22

... study, depending on the way in which productivity is valued, the costs of infliximab could be compensated for by savings in productivity [48]. Another study reviewing costs in early inflammatory ... disease processes and the prevention of development of further inflammation [9-11]. DMARDs are currently the first line of therapy in early inflammatory disease; howe...

Ngày tải lên: 09/08/2014, 10:20

... whether they currently smoked and the number of cigarettes smoked per day. From these reports, we calculated pack years of smoking (product of years of smoking and packs of cigarettes per day). Other ... smokers were asked for the number of cigarettes typically smoked per day and former smokers reported the age at which they stopped smoking and the number of cigarett...

Ngày tải lên: 09/08/2014, 10:23

... (LIPC) is a lipolytic enzyme synthesized in hepatocytes playing a major role in HDL metabolism. It takes part in hydrolysis of triacylglycerides and phosphol- ipids of HDL 2 into antiatherogenic, ... we constructed a risk profile. Carriers of the risk profile were defined as having one of the following polymorphisms: hetero- or homozygous for the variants of eNOS 4a...

Ngày tải lên: 10/08/2014, 10:20