Báo cáo y học: "Report on the Molecular Approaches to Osteoarthritis Symposium, Imperial College London, UK, 18–20 April 2004" docx

... Imperial College London, UK, 18–20 April 2004Jeremy Saklatvala and Hideaki NagaseKennedy Institute of Rheumatology, Imperial College Faculty of Medicine, London, UKCorresponding author: Jeremy Saklatvala, ... http://arthritis-research.com/content/6/5/203 The Kennedy Institute of Rheumatology Symposium Molecular Approaches to Osteoarthritis was held at Imperial College London on 18–20 April 2004. Itencompassed ... appearance and symptoms, and a lackof satisfactory markers for monitoring progression orresponses to therapy. Age, obesity, malalignment andprevious trauma to the joint are all risk factors and interactadditively....

Báo cáo y học: "Update on the treatment of ocular toxoplasmosis"

... survey of the opinion of oph-thalmic specialists in uveitis was performed recently by Gary Holland. [3] The reasons that were commonly accepted to introduce a therapy were the following: a) the ... ocular toxoplasmosis and not from primary infection. Disease evolution depends on many factors: the immune response of the host, the virulence of the parasite and environmental factors and ... lesion within the vascular arcades of the posterior pole (zone 1) b) the presence of a lesion in the proximity of the optic nerve or the macula c) or a severe inflammatory reaction within the...

Tài liệu Báo cáo Y học: Studies on the nonmevalonate pathway of terpene biosynthesis The role of 2C-methyl-D -erythritol 2,4-cyclodiphosphate in plants docx

... 2C-methyl-D-erythritol4-phosphate can be converted into a cyclic diphosphate by the consecutive action of 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, 4-diphosphocytidyl-2C-methyl-D-erythritolkinase ... Stereochemistry of the isoprenylation oftryptophan catalyzed by 4-(g,g-dimethylallyl) tryptophan synthasefrom Claviceps, the ﬁrst pathway-speciﬁc enzyme in ergot alkaloidbiosynthesis. J. Am. ... order to monitor the conversion of [1-3H]2C-methyl-D-erythritol 4-phosphateinto the corresponding 2,4-cyclodiphosphate. The organicphase was analyzed for3H and14C in order to monitor the transformation...

Báo cáo y học: "Shadows on the wall" ppsx

... cells. is one may actually be on the way out, I’m glad to say, but all the biology and biochemistry textbooks I’m aware of still imply it, if they don’t say so directly. I suspect many scientists ... originators’ hype proclaimed they would be. I don’t mind trying such things out to see if they might be useful, but we seem utterly unable to pull the plug on them, or even phase them out ... people of the cave can ever see are the shadows cast on the wall in front of them by those passing behind. All they can hear are the echoes in the cave produced by the movements they never see....

Báo cáo y học: " Analysis on the clinical features of 22 basaloid squamous cell carcinoma of the lung" doc

... pneumonectomy,lobectomy, segmentectomy) has no bearing on the prog-nosis of BC and PDSC patients [8].Differences between the findings in this study andother research may be due to variations in the source ... history,pulmonary function and the location of tumors [4]. The results of this study demonstrated that the mediansurvival time of basaloid squamous cell carcinoma andPDSC patients were 19 months ... wassignificantly influenced by treatment mode and clinicalstage of the tumor. The post-operation mortality hazardof patients treat ed with a combination of chemotherapyand radiation therapy was 1.296...

Báo cáo y học: "Developments in the clinical understanding of osteoarthritis" docx

... BMLs [20] are strongly related to risk of loss, especiallyoverlying the lesion.BMLs are not the only bone feature related to pain in OA.Attrition of bone is more common in persons with knee painand ... improved their OA symptoms. Since all types ofexercise appear to be effective, it may be best to prescribe the type of exercise most acceptable to the patient as thismay be one most likely to encourage ... picture.A new insight into the pathology of OA has been the recognition that modest enthesitis is a common feature. Inearly hand OA, there is inflammation at the boney insertion of the collateral ligaments...

Báo cáo y học: " Characterisation of the immune response to type I collagen in scleroderma" pps

... recently employed to study lym-phocyte responses to peanut allergens in children with peanutallergy [17]. The advantage of using CFSE over the traditional[3H]-thymidine incorporation method ... proliferative response to CI(as determined by CFSE staining and flow cytometry). After invitro activation of PBMCs with CI, the CFSElow population(antigen-activated) was sorted by flow cytometry andexpanded ... original publication of Stuart et al. [12]. To confirm our findings, we also analysed intracellular cytokineproduction by flow cytometry, using fluorochrome-conjugatedantibodies to IFN-γ and IL-4...

Báo cáo y học: "Developments in the scientific understanding of osteoarthritis" doc

... growth factors orinhibitors of inflammatory cytokines.Degeneration of articular cartilage in osteoarthritis: inflammation The role played by inflammatory cytokines and mediatorsproduced by joint ... conventionally considered an inflammatory arthritis, thatconcept - based historically on the numbers of leukocytes insynovial fluid - should be reconsidered. Indeed, ‘inflammatory’mediators perpetuate ... that, depending on size and location, the significance of bone marrow lesions in the individual patient might vary. The presence of bonemarrow lesions and their relation to progression has beenexplained...

Báo cáo y học: "Dextromethorphan attenuated the higher vulnerability to inflammatory thermal hyperalgesia caused by prenatal morphine exposure in rat offspring" docx

... sys-tem may contribute to the higher vulnerability to hyper-algesia. This requires further investigations on the possible change o f the opioidsystem.Sofar,wewereonly able to conclude that the quantitative ... morphine on the vulnerability to hyperalgesia have never been examined. In humans, the liability to inflammatory hyperalgesia is often affected byacquired physical conditions and social factors ... the dams mayaffect the developmen t of the neural systems which wil lbe functionally correlated with hyperalgesia in the off-spring. In order to investigate the vulnerability to hyper-algesia,...

Báo cáo y học: "Impact of the Kenya post-election crisis on clinic attendance and medication adherence for HIV-infected children in western Kenya"

... them to go on the roads and try to get [to clinic]. The risks to personal safety were seen to vary based on the fam-ilies' tribal affiliation, their location, and whether they were in the ... access to all the data in the study and hadfinal responsibility for the decision to submit for publica-tion. RCV conceived of the study, participated in its designand coordination, conducted the ... guide contain-ing open-ended questions. The facilitator solicited infor-mation on factors contributing to whether families wereable to return to clinic after the elections and on barriers to medication...

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