Báo cáo y học: "A proinflammatory role for Fas in joints of mice with collagen-induced arthritis" docx

... disease by destroying target tissues through induction of apoptosis of chondrocytes [33]. Alternatively, Fas could contribute to synovial hyperplasia by inducing proliferation of Fas- expressing synovial ... control mice with CIA reveal less inflammation/joint destruction in DBA-lpr/ lpr mice in spite of the same clinical score as that of control mice. The proinflamm...

Ngày tải lên: 09/08/2014, 01:23

... previously reported inactivity of the deletion mutants in response to the gp130-homodimerizing cytokine IL-6 [18]. Interestingly, also the formation of active hetero- dimers with wild-type LIFR in ... be involved in the dimerization and activation of gp130 by formation of disulfide bonds [30]. The analysis of cysteine residues in gp130 led to the finding that the two N-termi...

Ngày tải lên: 18/03/2014, 01:20

... well as spin labeling studies with aA-crystallin and Hsp27 [45] indicate that the dimeric building block of many a-Hsp proteins is formed by interacting bstrands in the a-crystallin domain. Although ... (1999) Site- directed spin labeling study of subunit interactions in the a-crys- tallin domain of small heat-shock proteins – comparison of the oligomer symmetry in aA-crystall...

Ngày tải lên: 31/03/2014, 21:21

... within inflamed joints appears to be reg- ulated not only by inflammatory cytokines but also by the physical interaction of activated leukocytes with FLSs. Once expressed, IP-10 probably plays ... significantly inhibited IP-10 induction. These results suggest that IP-10 expression within inflamed joints appears to be regulated not only by inflammatory cytokines but also by the physica...

Ngày tải lên: 09/08/2014, 01:21

... available bioinformatic resources; most often the written information describing gene function is very informative. The aim of this study was to facilitate this data mining by generating a web-based ... QTLs in rat were obtained from the RatMap database [7]. These data were originally collected from experimentally induced inflammatory arthritis in rat strains susceptible to the followin...

Ngày tải lên: 09/08/2014, 06:22

... analysis Analysis Details Serum biochemistry Albumin Alkaline phosphatase Total bilirubin Cholesterol Creatinine Creatine kinase-N-acetyl cysteine Glucose High-density lipoprotein Low-density lipoprotein Potassium Serum ... molecular mechanisms of action of an anti-inflammatory compound of herbal origin in the treatment of OA. We demonstrated that 5- Loxin ® has potential efficacy...

Ngày tải lên: 09/08/2014, 10:23

... Turpaz Y: Ploidy status and copy number aberrations in primary glioblastomas defined by integrated analysis of allelic ratios, signal ratios and loss of heterozygosity using 500K SNP Mapping Arrays. ... sample with relatively greater consistency. These results motivate the utility of infer- ring both baseline ploidy and normal contamination within an integrated framework since the...

Ngày tải lên: 09/08/2014, 22:23

... chromatin features are redundant, and to what extent they are interac ting in a combinatorial fashion. Specifically, for each bin, we modeled the expression level y as a linear combination of the ... high accuracy Do chromatin features inf luenc e tra nscription of micro- RNAs in the same way as they do with protein-coding genes? As a way to study the similarity of the two mec...

Ngày tải lên: 09/08/2014, 22:23

... ATP binding site serves as a docking site for specific binding of cytoplasmic signaling proteins containing Src homology-2 (SH2) and protein tyrosine binding (PTB) domains. These proteins in ... transforming non receptor tyrosine kinase activity [4], and the finding of EGFR, the first receptor tyrosine kinase paved the way to the understanding of the role and significance of...

Ngày tải lên: 03/11/2012, 09:57

... Fi. As indicated by Turkish data in sections 1 and 2, Fi may in fact have a domain larger than but com- patible with Di. In order to perform morphological and syntactic compositions in a unified ... mor- phology and syntax, for instance the change in the scope of modifiers and genitive suffixes, or valency and thematic role change in causatives. To model interacti...

Ngày tải lên: 08/03/2014, 07:20