Báo cáo y học: "Targeting the interleukin-15/interleukin-15 receptor system in inflammatory autoimmune diseases" pot

... the life and death of lymphocytes, especially in adaptive immune responses [13]. Commentary Targeting the interleukin-15/interleukin-15 receptor system in inflammatory autoimmune diseases Thomas ... with severe combined immunodeficiency. In a murine model the intra-articular injection of IL-15 induced a local tissue inflammatory infiltrate that was predominantly of T l...

Ngày tải lên: 09/08/2014, 01:23

... Finally, type C CpG- ODNs contain a 5′ TCG motif and CpG-containing palindromes, allowing them to form secondary structures. These ODNs stimulate both B cells and pDCs in the human system. Interestingly, ... TLRs in the pathogenesis of systemic autoimmunity. Do Toll-like receptors contribute to systemic autoimmunity? Infections frequently precede the occurrence of either organ- spe...

Ngày tải lên: 09/08/2014, 07:20

... his- tamine or methacholine, which indicates that these mediators are extremely potent. 5 The cysteinyl leukotrienes exert their biologic effects by binding to cysteinyl leukotriene receptors ... arachidonic acid, thereby preventing cysteinyl leukotriene synthe- sis (see Figure 1). Blocking arachidonic enzy- matic conversion by the use of 5-lipoxygenase inhibitors does protect against EIB...

Ngày tải lên: 08/08/2014, 20:23

... is the archetypal proinflammatory receptor and a member of the TNF receptor superfamily – a Review Falling into TRAPS – receptor misfolding in the TNF receptor 1-associated periodic fever syndrome Fiona ... caused by mutations in the gene encoding the neutrophil-specific protein Pyrin [2]. Most evidence currently suggests that pyrin negatively regulates the production...

Ngày tải lên: 09/08/2014, 10:20

... and the final paper. ZR contributed in the analysis of the data and to interpreta- tion and the draft and the final paper. CF and AI contrib- uted in the design of the protocol, the gathering ... SJ, Akil H, Young E: Hypothalamic-pituitary-adrenal axis peptides in affective disease: focus on the ACTH/β- endorphin system. In Handbook of Clinical Psychoneuroendocrinol...

Ngày tải lên: 08/08/2014, 23:21

... expression or affinity of these IgG receptors or that enhance their ability to bind spe- cific IgG isotypes may therefore play an important role in deter- mining the severity and persistence of inflammation ... may be critical modulators of inflammation within the synovium and that subtle changes in either expression or structure of these receptors may influence both the susceptibil...

Ngày tải lên: 09/08/2014, 07:20

... response system, the ANS, in patients with FM. Autonomic nervous system The ANS is the main regulatory system of the body in charge of maintaining essential involuntary functions, such as the so- called ... the involvement of the sympathetic nervous system in the genesis of FM pain are the reports describing such pain as appearing submissive to sympatholytic man...

Ngày tải lên: 09/08/2014, 10:20

... identified: a primary phase directly after the start of treatment and a secondary phase that develops in initial responders during the course of therapy. The latter is explained by the formation of ... during therapy Editorial Predicting the future of anti-tumor necrosis factor therapy Cornelis L Verweij Division of Inflammatory Disease Profiling, Department of Pathology and Rhe...

Ngày tải lên: 09/08/2014, 14:21

... hospitalized elderly adults will continue to in- crease in the coming decades. The National Health Inter- view Survey reports that in the United States in 1994, 8.3 million individuals over 65 years of ... is the sum of the distress scores obtained for each behavioral category. The NPI-Q takes approximately 10 minutes to administer. In the current study the caregiver...

Ngày tải lên: 08/08/2014, 20:23

... found at sites where these cells are normally absent or are only scarcely present [5]. On the basis of these data, the hypothesis that the inflammatory events in RA prima- rily lead to activation ... highly dependent on the proximity to the inflamed synovial mem- brane. The area closest to inflammatory tissue is the subchon- dral bone of the junction zone, where the sy...

Ngày tải lên: 09/08/2014, 07:20